Abstract：
:Movement of fragmented DNA in dendrites of retinal neurons during the apoptotic cell death was investigated. The time-course of the movement of fragmented DNA in dendrites of retinal neurons undergoing apoptotic cell death induced by intravitreal N-methyl-d-aspartate (NMDA) injection were examined by in situ terminal dUTP-biotin nick end labeling of DNA fragments (TUNEL) method and fluorescence DNA detection technique by 4',6-diamidino-2-phenylindole (DAPI). The inhibitory effect of axoplasmic transport inhibitor, vincristine was also tested on the NMDA-induced fragmented DNA transport. The movement of fragmented DNA from apoptotic nuclei toward peripheral ends of the dendrites of the retinal neurons was clearly demonstrated. The transport of fragmented DNA, but not fragmentation per se, was completely inhibited by the co-administration of vincristine.
journal_name
Brain Resjournal_title
Brain researchauthors
Hara A,Niwa M,Kumada M,Kitaori N,Yamamoto T,Kozawa O,Mori Hdoi
10.1016/j.brainres.2004.01.075subject
Has Abstractpub_date
2004-05-08 00:00:00pages
183-7issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304001581journal_volume
1007pub_type
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