Reduced availability of brain amines during critical phases of postnatal development in a genetic mouse model of cognitive delay.

abstract：:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...

journal_title：Brain research

authors： Mischler SA,Alexander M,Battles AH,Raucci JA Jr,Nalwalk JW,Hough LB

更新日期：1994-03-21 00:00:00

abstract：:We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...

journal_title：Brain research

authors： Zhang RL,Chopp M,Zhang ZG,Jiang Q,Ewing JR

更新日期：1997-08-22 00:00:00

abstract：:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...

journal_title：Brain research

authors： Ishiyama T,Ogo H,Wong V,Klinkosz B,Noguchi H,Nakayama C,Mitsumoto H

更新日期：2002-07-19 00:00:00

abstract：:At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

journal_title：Brain research

authors： Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

更新日期：1991-08-23 00:00:00

abstract：:In this study, seizures in the dentate gyrus were triggered by 2 Hz electrical stimulation while, at the same time, serial changes in paired-pulse depression was measured in free-moving rats. The perforant path was stimulated by paired pulses 25 ms apart and recordings were made in the dentate gyrus. We also observed ...

journal_title：Brain research

authors： Emori K,Katsumori H,Minabe Y

更新日期：1997-11-21 00:00:00

abstract：:The effect of single administrations of MK-801 (5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine) or PCP (phencyclidine) on the induction of audiogenic seizure susceptibility by noise in immature rats was examined. Treatments with these non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists resul...

journal_title：Brain research

authors： Pierson M,Swann J

更新日期：1991-09-27 00:00:00

abstract：:Amyloid precursor protein (APP) is a ubiquitously expressed membrane spanning glycoprotein which is endoproteolytically processed to Abeta, a 39-43 amino acid peptide that is the main component of senile plaques in Alzheimer Disease (AD). APP is a member of a highly conserved gene family, including Amyloid Precursor-L...

journal_title：Brain research

authors： McNamara MJ,Ruff CT,Wasco W,Tanzi RE,Thinakaran G,Hyman BT

更新日期：1998-08-31 00:00:00

abstract：:Tyrosine hydroxylase immunohistochemical analysis was performed on tissue sections through the pallidal complex from Nemistrina monkeys which had been made hemi-parkinsonian by intracarotid MPTP infusion 8-12 months earlier. The side contralateral to the MPTP infusion showed a dense dopaminergic innervation of the pal...

journal_title：Brain research

authors： Schneider JS,Dacko S

更新日期：1991-08-16 00:00:00

abstract：:Alpha-lipoic acid (ALA) is an endogenous short-chain fatty acid that has beneficial protective effects against various vascular diseases. In this study, we sought to determine whether ALA could induce pre- or post-treatment protective effects against simulated ischemia and reperfusion-induced cerebral endothelial cell...

journal_title：Brain research

authors： Xie R,Li X,Ling Y,Shen C,Wu X,Xu W,Gao X

更新日期：2012-10-30 00:00:00

abstract：:Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...

journal_title：Brain research

authors： Warton SS,Jones DG

更新日期：1984-05-01 00:00:00

abstract：:Administration of methamphetamine (15 mg/kg) to adrenalectomized rats significantly decreased hippocampal type I and II corticosteroid receptors as well as type II receptors in the striatum. Type II receptors in the frontal cortex and hypothalamus were unaffected by methamphetamine administration. Pretreatment with MK...

journal_title：Brain research

authors： Lowy MT

更新日期：1990-11-19 00:00:00

abstract：:Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the e...

journal_title：Brain research

authors： Lewis VA,Gebhart GF

更新日期：1977-03-25 00:00:00

abstract：:In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...

journal_title：Brain research

authors： Santizo RA,Xu HL,Ye S,Baughman VL,Pelligrino DA

更新日期：2002-11-22 00:00:00

abstract：:Experimental studies and clinical observations show that spinal cord lesions are greatly enlarged by a process called secondary cell death. A detailed understanding of the molecular and cellular processes underlying these events is still lacking. In clinical studies using methylprednisolone in spinal cord injured pati...

journal_title：Brain research

authors： Bartholdi D,Schwab ME

更新日期：1995-02-20 00:00:00

abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...

journal_title：Brain research

authors： Sun W,Deng A,Jayaram A,Gibson B

更新日期：2012-11-16 00:00:00

abstract：:Several neurodevelopmental disorders, including schizophrenia, autism, ADD/ADHD and dyslexia are believed to originate during gestation and involve white matter abnormalities. Modulation of glutamate environments and glutamate receptors has also been implicated in alteration of oligodendrocytes, the myelin forming cel...

journal_title：Brain research

authors： Lindahl JS,Kjellsen BR,Tigert J,Miskimins R

更新日期：2008-10-09 00:00:00

abstract：:The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pa...

journal_title：Brain research

authors： Wang M,Tang ZX,Li BM

更新日期：2004-10-22 00:00:00

abstract：:Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 microM bradykinin fo...

journal_title：Brain research

authors： Gebreyesus K,Kilbourne EJ,Sabban EL

更新日期：1993-04-16 00:00:00

abstract：:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ...

journal_title：Brain research

authors： Heyman JS,Mulvaney SA,Mosberg HI,Porreca F

更新日期：1987-09-08 00:00:00

abstract：:Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calc...

journal_title：Brain research

authors： Wright DM

更新日期：1984-10-08 00:00:00

abstract：:Dissimilarity of the electroencephalogram (EEG) between the two hemispheres was characterized by cross-approximate entropy (C-ApEn), an information statistical parameter applicable to nonlinear, aperiodic signals. EEGs were recorded bipolarly with pairs of epidural electrodes in the left and right frontal cortices. Th...

journal_title：Brain research

authors： Hudetz AG

更新日期：2002-11-01 00:00:00

abstract：:Focal cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators (Clark et al., Brain Res. Bull., 35 (1994) 387-392; Garcia et al., Am. J. Pathol., 144 (1994) 188-199; Wang et al., J. Neurochem. 71 (1998) 1194-...

journal_title：Brain research

authors： Che X,Ye W,Panga L,Wu DC,Yang GY

更新日期：2001-06-01 00:00:00

abstract：:Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine...

journal_title：Brain research

authors： Lees GJ,Horsburgh RJ

更新日期：1984-06-03 00:00:00

abstract：:A small, unilateral, penetrating wound was placed in the dorsolateral portion of the lumbosacral spinal cord in immature rats. Although this wound did not extend into the central canal area, some cells forming the walls of this canal underwent proliferative activity as demonstrated by [3H]thymidine autoradiography. Th...

journal_title：Brain research

authors： Gilmore SA,Leiting JE

更新日期：1980-11-10 00:00:00

abstract：:Stanniocalcin (STC-1), a 50 kDa glycoprotein hormone that regulates calcium/phosphate homeostasis in bony fish and mammals, has been shown to be expressed in central neurons and choroid plexus, and to exert a protective effect against hypercalcemic and hypoxic damage to neurons. Circumventricular organs are known to f...

journal_title：Brain research

authors： Ratkovic S,Wagner GF,Ciriello J

更新日期：2008-07-07 00:00:00

abstract：:We previously reported that oral l-citrulline (l-Cit) administration antagonizes neuronal cell death in hippocampus following transient brain ischemia and that oral glutathione (GSH) administration prevents neuronal death through antioxidant activity. Here, we tested potential synergy of combined l-Cit and GSH adminis...

journal_title：Brain research

authors： Matsuo K,Yabuki Y,Fukunaga K

更新日期：2017-05-15 00:00:00

abstract：:GABAA receptors (GABAARs) and glycine receptors (GlyRs) are two principal inhibitory chloride ion channels in the central nervous system. The two receptors do not function independently but cross-talk to each other, i.e., the activation of one receptor would inhibit the other. This cross-talk is present in different p...

journal_title：Brain research

authors： Tang ZQ,Lu YG,Huang YN,Chen L

更新日期：2020-12-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothe...

journal_title：Brain research

authors： Kuramoto S,Yasuhara T,Agari T,Kondo A,Jing M,Kikuchi Y,Shinko A,Wakamori T,Kameda M,Wang F,Kin K,Edahiro S,Miyoshi Y,Date I

更新日期：2011-01-12 00:00:00

abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...

journal_title：Brain research

authors： Liu B,Guo Z,Dong H,Daofeng T,Cai Q,Ji B,Zhang S,Wu L,Wang J,Wang L,Zhu X,Liu Y,Chen Q

更新日期：2015-06-22 00:00:00

abstract：:Partial sciatic nerve ligation in mice caused a marked and persistent decrease in the latency of paw withdrawal from a thermal stimulus only on the ipsilateral side. This thermal hyperalgesia was abolished by repeated intrathecal pretreatment with a specific antibody to brain-derived neurotrophic factor (BDNF), but no...

journal_title：Brain research

authors： Yajima Y,Narita M,Narita M,Matsumoto N,Suzuki T

更新日期：2002-12-27 00:00:00