Abstract:
:Antibodies to dopamine beta-hydroxylase (anti-D beta H) were taken up by noradrenergic nerve terminals in the iris following attachment to D beta H, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine, injected intraocularly, blocked the retrograde transport of anti-D beta H. However, recovery was rapid, reaching 50% of control values within 1 day. Such transport was characterized by a shorter time period before accumulation could be detected in the SCG and by a slower rate of accumulation. These results suggest that noradrenergic neurons recover their ability to turn over synaptic vesicles by exocytosis and transport these back to the ganglion early during the period of axonal regeneration when the axonal length is shorter than normal. The uptake and transport of anti-D beta H was regulated by alpha-adrenergic agents administered locally in the vicinity of noradrenergic nerve terminals. Thus intraocular injection of phentolamine resulted in an increased accumulation of anti-D beta H in the SCG, while amphetamine and the postsynaptic alpha-receptor antagonist, phenylephrine, decreased accumulation. Clonidine and desipramine, which have a predominant presynaptic action, failed to influence the transport of anti-D beta H. These results suggest that in vivo the uptake of anti-D beta H can be increased more by local postsynaptic reflex actions than by a mechanism depending on the inhibition of presynaptic alpha-receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Lees GJ,Horsburgh RJdoi
10.1016/0006-8993(84)91097-7subject
Has Abstractpub_date
1984-06-03 00:00:00pages
281-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)91097-7journal_volume
301pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Homer1a is implicated in depression in humans and depression-like behavior in mice. To further understand the role of Homer1a in stress-induced emotional changes, we applied very mild stress to Homer1a knockout (H1a KO) mice. The wild-type (WT) and H1a KO mice were restrained for 2h daily for 7 consecutive days at the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.008
更新日期:2015-04-24 00:00:00
abstract::Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.02.041
更新日期:2015-05-22 00:00:00
abstract::During the early postnatal development of the rat large numbers of pyramidal tract neurons are present in layer V of the occipital cortex, but by the end of the third postnatal week the distribution of pyramidal tract neurons becomes restricted to the more rostral cortical areas. This restriction is brought about by s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90661-4
更新日期:1985-06-17 00:00:00
abstract::Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01768-0
更新日期:1999-09-04 00:00:00
abstract::Using a double-labelling procedure, morphological relationships existing between dopaminergic and indoleaminergic neuronal systems in the rat brain were investigated. First, thanks to a tryptamine (T) antiserum, we visualized this indoleamine in all mesencephalic regions and showed that the T-immunoreactivity (IR) see...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91182-g
更新日期:1990-03-26 00:00:00
abstract::Porcine calcitonin (pCT) encapsulated in sulfatide-containing reverse-phase evaporation vesicles (REVs) was shown to induce long-lasting and dose-dependent antinociceptive effect by systemic injection in mice. Its antinociceptive activity is found to be dependent on the route of administration. In contrast, neither un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91311-f
更新日期:1993-02-12 00:00:00
abstract::The dependence of the carotid chemosensory response to hypoxia on metabolic substrate and the hypothesis that lactic acidosis is essential for O2 chemoreception were tested. Effects of 3 types of substrate (glucose, glutamate and a mixture of amino acids) on the response to hypoxia (perfusate flow interruption) were m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91535-m
更新日期:1992-11-20 00:00:00
abstract::In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91089-1
更新日期:1981-12-07 00:00:00
abstract::Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01195-1
更新日期:1995-12-12 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01461-p
更新日期:1995-02-27 00:00:00
abstract::Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91444-6
更新日期:1991-12-13 00:00:00
abstract::We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists on habenular Fos expression. Rats were inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01353-4
更新日期:1997-03-07 00:00:00
abstract::Responses to rotation in many vertical and horizontal planes were studied in electrically identified secondary vestibular neurons of alert cats. This report concerns secondary neurons that gave responses which could not be explained as due to a summation of semicircular canal inputs. These cells responded to sinusoida...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91318-0
更新日期:1984-02-27 00:00:00
abstract::Different doses of angiotensin II (AII) or angiotensin III (AIII) microinjections into the zona incerta have been studied on drinking of rats in separate experiments during the consequent 60-min-daily-drinking period. Also, the dipsogen power of only the effective dose of AII and AIII was compared to vehicle treated r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02680-5
更新日期:2003-07-11 00:00:00
abstract::In order to better understand the neuroleptic-like effects of neurotensin in vivo, the effects of neurotensin in vitro on dopamine D2 and D1 agonist and antagonist binding sites were characterized in membranes from the neostriatum and the subcortical limbic area. Neurotensin increased the KD but not the Bmax value of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90753-i
更新日期:1991-10-04 00:00:00
abstract::Repeated doses of estradiol benzoate (10 micrograms/kg, s.c., once a day for 2, 5 or 8 days) to male rats decreased gamma-aminobutyric acid (GABA) content and glutamate decarboxylase (GAD) activity in substantia nigra (SN) but failed to change these parameters in hippocampus, cerebral cortex, cerebellum, lateral septu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90404-4
更新日期:1985-04-15 00:00:00
abstract::Rats were subjected to transient global ischemia (four vessel occlusion) and time-related changes in the selectively vulnerable hippocampal field CA1 were characterized. The assessment included ex vivo field responses to afferent stimulation, silver staining, calpain-induced spectrin breakdown, chromatolysis, and cell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01414-5
更新日期:1998-04-20 00:00:00
abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03291-7
更新日期:2002-01-25 00:00:00
abstract::The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90071-6
更新日期:1988-08-02 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.02.040
更新日期:2005-05-10 00:00:00
abstract::Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone that is required for the biogenesis of multiple ribonucleoprotein (RNP) complexes including spliceosomal small nuclear RNPs (snRNPs). Re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2018.02.022
更新日期:2018-08-15 00:00:00
abstract::Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against isch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.060
更新日期:2009-09-29 00:00:00
abstract::Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91081-3
更新日期:1993-10-22 00:00:00
abstract::Vascular permeability and intravascular space in the rat cerebral cortex and hypothalamus were assessed 5 and 14 days after the production of either right or left hemisphere frontal cortical suction lesions. Rats were intravenously injected with large (dextran, 50,000 kdalton) and small (inulin, 5000 kdalton) molecula...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91414-3
更新日期:1985-12-16 00:00:00
abstract:BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.095
更新日期:2010-10-08 00:00:00
abstract::The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90678-6
更新日期:1988-11-22 00:00:00
abstract::The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91058-m
更新日期:1992-11-13 00:00:00
abstract::Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00076-6
更新日期:1998-03-30 00:00:00