Abstract：
:Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the effect of morphine intracerebrally (i,c.) administered into the PAG was not duplicated by other centrally acting agents (chlorpromazine, chlordiazepoxide, pentobarbital or naloxone) administered i.c. at the same PAG site. This selective action of morphine in the PAG was further demonstrated not to be test-bound since morphine significantly altered responding in all four of the analgesiometric tests employed. Thus, multiple i.c. injections of drugs at the same PAG locus were useful in demonstrating site specificity of drug action where behavioral and electroencephalographic methods alone had previously provided ambiguous information. Morphine-induced analgesia and SPA, evaluated at virtually coincident PAG sites, revealed only a general congruence of efficacious loci. The most effective PAG loci for morphine-induced analgesia were not the same as those for SPA; analgesia effected by one analgesia-producing manipulation did not reliably predict that analgesia would also be produced by the other analgesia-producing manipulation at the PAG sites examined. In general, the more efficacious analgesia-producing PAG loci were localized in the ventral-ventrolateral PAG.
journal_name
Brain Resjournal_title
Brain researchauthors
Lewis VA,Gebhart GFdoi
10.1016/0006-8993(77)90886-1subject
Has Abstractpub_date
1977-03-25 00:00:00pages
283-303issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(77)90886-1journal_volume
124pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In spite of the numerous reports on the optic fiber distribution in the optic nerve and tract of vertebrates, there have been few studies of the visual pathway in reptiles. The arrangement of fibers in the optic nerve and tract of the turtle Mauremys leprosa was studied by placing a small granule of carbocyanine dye (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.016
更新日期：2007-12-01 00:00:00
abstract：:Recent radioligand binding studies demonstrated an increase in the density of dopamine D2 receptors in the nucleus accumbens ipsilateral to the stimulating electrode in amygdala- or hippocampal-kindled rats. In the present study we examined the anticonvulsant effect of dopamine agonists by unilateral microinjections i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90822-d
更新日期：1991-07-12 00:00:00
abstract：:It was previously reported that chronic food restriction and maintenance of rats at 75-80% of initial body weight enhanced the reward-potentiating effect of D-amphetamine in the lateral hypothalamic self-stimulation (LHSS) paradigm. Moreover, the enhancement reversed in parallel with body weight recovery when ad libit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.002
更新日期：2006-05-04 00:00:00
abstract：:Trophic effects of neurturin, a member of the glial cell line-derived neurotrophic factor-family, have been demonstrated on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease. This study was designed to test the neuroprotective and regenerative effects of an intrastriatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02934-7
更新日期：2002-08-30 00:00:00
abstract：:The role of the substantia innominata (SI) in the generation of a behavior mediated by the prefrontal (PF) cortex was examined in two Japanese monkeys. PF neuronal activities related to a visual tracking task by wrist movement were recorded and neural responses to SI stimulation were analyzed. Sixty-six neurons showed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90734-5
更新日期：1983-10-16 00:00:00
abstract：:Bombesin-like immunoreactivity occurs in a dense network of nerve fibres in the rat coeliac-superior mesenteric ganglion. No bombesin immunoreactive cell bodies have been observed in this ganglion. An origin outside the ganglion was therefore assumed for the bombesin immunoreactive fibres. Ligation of the mesenteric n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90981-2
更新日期：1983-06-13 00:00:00
abstract：:Biocytin, a naturally occurring low molecular weight analog of biotin, was evaluated as a neuroanatomical tract-tracing marker in the adult rat brain. Since it retains high-affinity binding to avidin, biocytin can be labelled with avidinylated visualization reagents. Iontophoretic or pressure injections resulted in fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90281-3
更新日期：1989-09-18 00:00:00
abstract：:Kindling of the amygdaloid complex in rats results in an enhanced emotionality frequently expressed by an elevated anxiety and defensive attitude toward other animals. Defensive attitude may have important consequences in social context and if tested in a large space it may eventually lead to social withdrawal. To tes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03162-6
更新日期：2001-12-13 00:00:00
abstract：:Ethanol caused a concentration-dependent loss of PC12 cells over a 24 h interval, accompanied by an increase in intracellular calcium. The specific alpha7 nicotinic receptor partial agonist DMXB attenuated both of these ethanol-induced actions at a concentration (3 microM) found previously to protect against apoptotic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01153-6
更新日期：1999-01-16 00:00:00
abstract：:Previous work has demonstrated that the GABAergic system is involved in sexual differentiation of the rodent hypothalamus. The present study was designed to further examine this involvement by investigating developmental sex differences in GAD(65) protein levels in hypothalamic and extrahypothalamic brain regions know...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03167-5
更新日期：2001-12-20 00:00:00
abstract：:Tissue prisms prepared from neurosurgical samples of temporal neocortex of Alzheimer and control patients, upon depolarization preferentially released aspartate, glutamate and gamma-aminobutyrate (GABA). The Alzheimer and control samples did not significantly differ in the pattern of amino acid release, although acety...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91131-9
更新日期：1983-03-28 00:00:00
abstract：:Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.026
更新日期：2015-07-30 00:00:00
abstract：:We have recently reported that the burst firing neurons are found in layer III as well as in layer V of cat sensorimotor cortex in vitro. In the present study, we examined the synaptic excitability of layer III neurons by white matter stimulation and compared with their firing patterns against the current injections t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01850-8
更新日期：1999-09-18 00:00:00
abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03766-6
更新日期：2003-04-18 00:00:00
abstract：:Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03148-1
更新日期：2001-12-13 00:00:00
abstract：:A histochemical stain for cytochrome oxidase (CO) activity was used to examine the maturation of a neurochemical correlate of ON and OFF channels in the retina and dorsal lateral geniculate nucleus (LGN) of the tree shrew. In the adult tree shrew, the CO staining pattern can be used as a histochemical marker of segreg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90217-3
更新日期：1987-08-01 00:00:00
abstract：:The HSD2 (11-beta-hydroxysteroid dehydrogenase-type 2 enzyme) containing neurons of the nucleus tractus solitarius (NTS) become activated during low-sodium and high-aldosterone states such as hypovolemia. This response may be due to hormonal and/or neural signals. Hormonal signals may activate neurons in the area post...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.098
更新日期：2009-12-08 00:00:00
abstract：:Male guinea pigs were given 3 tests for sexual behavior. Animals that never ejaculated were classified as low activity (LA), animals that ejaculated on one test were classified as medium activity (MA), and animals that ejaculated on two or more tests were classified as high activity (HA). Subsequently, animals from ea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90929-x
更新日期：1976-03-19 00:00:00
abstract：:We have previously found that the amyloid precursor protein (APP) of Alzheimer's disease is present on the surface of rat cortical neurons in culture, in a segmental pattern which first becomes evident after 24 hours and is fully developed by five days. As APP has previously been reported to have a short half-life in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00609-9
更新日期：1996-09-30 00:00:00
abstract：:In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the res...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91453-3
更新日期：1987-05-26 00:00:00
abstract：:The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01331-6
更新日期：1999-02-27 00:00:00
abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02086-8
更新日期：2001-04-06 00:00:00
abstract：:Microinjection of the neuronal inhibitor muscimol into the midbrain lateral/dorsolateral periaqueductal gray (l/dlPAG) suppresses increases in heart rate (HR) and mean arterial pressure (MAP) evoked by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) into the dorsomedial hypothalamus (DMH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.080
更新日期：2006-05-30 00:00:00
abstract：:Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90831-0
更新日期：1986-04-16 00:00:00
abstract：:Electroconvulsive stimulation (ECS), the experimental analogue of electroconvulsive therapy (ECT), has been shown to produce both functional and structural effects in the hippocampal formation in infrahuman species. These changes may relate to the antidepressant and cognitive effects of ECT observed in patients treate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.041
更新日期：2005-08-16 00:00:00
abstract：:Anandamide, the ethanolamide of arachidonic acid, is an endogenous cannabinoid. It is an agonist at CB1 and CB2 cannabinoid receptors as well as the vanilloid receptor, VR1. It is analgesic in inflammatory and neuropathic pain. Both central and peripheral mechanisms are considered to participate in its analgesia. Prim...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.004
更新日期：2005-11-16 00:00:00
abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90910-4
更新日期：1990-05-14 00:00:00
abstract：:The aim of this study was to evaluate the effects of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the developing brain. Thirty-seven newborn piglets were divided randomly into four groups: normothermic control (NC, n=9); hypothermic control (HC, n=7); normotherm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03186-9
更新日期：2001-12-20 00:00:00
abstract：:During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.11.010
更新日期：2014-01-16 00:00:00
abstract：:In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.01.032
更新日期：2015-04-07 00:00:00
