Abstract：
:Administration of methamphetamine (15 mg/kg) to adrenalectomized rats significantly decreased hippocampal type I and II corticosteroid receptors as well as type II receptors in the striatum. Type II receptors in the frontal cortex and hypothalamus were unaffected by methamphetamine administration. Pretreatment with MK-801, a non-competitive antagonist of N-methyl-D-aspartate receptors, antagonized the methamphetamine-induced decrease in hippocampal and striatal corticosteroid receptors. These results are in agreement with previous studies demonstrating that some of the neurobiological effects of methamphetamine may be mediated via a mechanism involving excitatory amino acids.
journal_name
Brain Resjournal_title
Brain researchauthors
Lowy MTdoi
10.1016/0006-8993(90)91362-ksubject
Has Abstractpub_date
1990-11-19 00:00:00pages
348-52issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91362-Kjournal_volume
533pub_type
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