Abstract：
:Parkinson's disease is characterized by a loss of dopaminergic neurons in the substantia nigra and, in the most severe cases, by degeneration of mesopontine cholinergic neurons. In a monkey model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine we report that, despite a severe loss of dopaminergic neurons, in the mesopontine tegmentum cholinergic neurons are preserved in the same region. This suggests that the loss of mesopontine cholinergic neurons in parkinsonian patients may represent an end-stage degenerative process, the cause of which may be independent of the mechanism of dopaminergic cell death.
journal_name
Brain Resjournal_title
Brain researchauthors
Herrero MT,Hirsch EC,Javoy-Agid F,Obeso JA,Agid Ydoi
10.1016/0006-8993(93)90088-5subject
Has Abstractpub_date
1993-10-08 00:00:00pages
281-5issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90088-5journal_volume
624pub_type
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