On the origin of substance P and glutamic acid decarboxylase (GAD) in the substantia nigra.

abstract：:We have examined the saturation features (Kd and Bmax) of [3H]naloxone binding in rat brain regions in cytoarchitectonically intact tissues of naive, morphine dependent and precipitated withdrawal states using quantitative film autoradiography. Sixty-one saturation experiments in 13 regions of naive rat brains yielded...

journal_title：Brain research

authors： Geary WA 2nd,Wooten GF

更新日期：1985-12-23 00:00:00

abstract：:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (I...

journal_title：Brain research

authors： Hennings EC,Kiss JP,Vizi ES

更新日期：1997-06-13 00:00:00

abstract：:Monoamine uptake inhibitors block the neurotoxic effects of methamphetamine (MA) upon dopaminergic and serotonergic neurons in the rat. The neurotoxic effects of MA upon dopaminergic neurons have previously been suggested to be mediated via formation of 6-hydroxydopamine (6-OHDA) from endogenous stores of dopamine (DA...

journal_title：Brain research

authors： Marek GJ,Vosmer G,Seiden LS

更新日期：1990-05-14 00:00:00

abstract：:The subfornical organ of the brain has a role in the regulation of fluid balance in higher animals. In this study the effects of salt loading and water deprivation on specific proteins in this organ were investigated. For 4 days, 3 groups of rats were given an appropriate fluid diet (control, 2% NaCl and water deprive...

journal_title：Brain research

authors： Santer DM,Heydorn WE,Creed GJ,Klein DC,Jacobowitz DM

更新日期：1986-04-30 00:00:00

abstract：:Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...

journal_title：Brain research

authors： Kashiba H,Senba E,Ueda Y,Tohyama M

更新日期：1990-10-01 00:00:00

abstract：:The periodicity of the myelin sheath in glutaraldehyde carbohydrazide (GACH) embedded tissues from three 10-day-old and two 43-day-old mice was investigated with the electron microscope. The mean repeat period and number of repeats per fiber was measured in 31-89 fibers in the trapezoid bodies, olfactory tract and sci...

journal_title：Brain research

authors： Hedley-Whyte ET,Kirschner DA

更新日期：1976-09-03 00:00:00

abstract：:Focal electrical stimulation and glutamate microinjection in the nuclei reticularis gigantocellularis (NGC) and gigantocellularis pars alpha (NGC alpha) both inhibit the nociceptive tail-flick (TF) reflex in rats. The present experiments were undertaken to determine the transmitter(s) at the level of the lumbar spinal...

journal_title：Brain research

authors： Zhuo M,Gebhart GF

更新日期：1990-12-03 00:00:00

abstract：:Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...

journal_title：Brain research

authors： Wang W,Richerson GB

更新日期：2000-03-31 00:00:00

abstract：:Pain resulting from peripheral nerve injury, characterised by ongoing pain, hyperalgesia and allodynia arises from peripheral and central processes. Here, we studied the potential role of central facilitations in nerve injury by investigating the effect of blocking the excitatory 5HT3 receptor with ondansetron. 5HT3 r...

journal_title：Brain research

authors： Suzuki R,Rahman W,Hunt SP,Dickenson AH

更新日期：2004-09-03 00:00:00

abstract：:Synaptic plasma membrane preparations from brain tissue have endogenous Ca2+-dependent phospholipase A2 activity. Characterization of this activity revealed that it was maximally active at 10(-7)-10(-5) M Ca2+ and pH 7.0. The enzyme had a Km of 62.0 microM and a Vmax of 98.0 nmol/mg/h. Calmodulin and prostaglandin F2 ...

journal_title：Brain research

authors： Moskowitz N,Schook W,Puszkin S

更新日期：1984-01-09 00:00:00

abstract：:Recently, Somberg, in a preliminary report (1983), noted that electrical stimulation of the area postrema causes an increase in coronary vascular resistance. The increase in resistance was mediate by an increase in sympathetic activity as it was counteracted by alpha-adrenergic receptor blockade. The purpose of our st...

journal_title：Brain research

authors： Gatti PJ,Dias Souza J,Gillis RA

更新日期：1988-05-17 00:00:00

abstract：:Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...

journal_title：Brain research

authors： Wang JQ,McGinty JF

更新日期：1995-03-06 00:00:00

abstract：:In the present study we investigated whether nitroflurbiprofen (NFP) or nitro-aspirin can reduce the inflammatory response induced by continuous infusion of lipopolysaccharide (LPS) into the fourth ventricular space of the rat's brain for 30 days. The chronic LPS infusion produced an extensive inflammation that was pa...

journal_title：Brain research

authors： Hauss-Wegrzyniak B,Willard LB,Del Soldato P,Pepeu G,Wenk GL

更新日期：1999-01-02 00:00:00

abstract：:Magnetoencephalography (MEG) was used to investigate the response to speech sounds that differ in onset dynamics, parameterized as words that have initial stop consonants (e.g., /b/, /t/) or do not (e.g., /m/, /f/). Latency and amplitude of the M100 auditory evoked neuromagnetic field, recorded over right and left aud...

journal_title：Brain research

authors： Gage N,Poeppel D,Roberts TP,Hickok G

更新日期：1998-12-14 00:00:00

abstract：:Chronic pain tends to be intractable, regardless of whether the etiology has improved or is persistent. This intractability may be due, in part, to conditioning factors, but studies of the underlying mechanism are limited. We predicted that the body might learn pain sensation during sustained pain. In the present stud...

journal_title：Brain research

authors： Nakama-Kitamura M,Kitamura Y

更新日期：2011-08-11 00:00:00

abstract：:The effect of aminoguanidine (AG) on structural abnormalities in optic nerve fibers was evaluated in streptozotocin-induced diabetic rats. Morphometry of myelinated optic nerve fibers showed a partial amelioration on the reduction of the axon size but complete preservation of myelin size with low dose (25 mg kg-1 body...

journal_title：Brain research

authors： Ino-ue M,Ohgiya N,Yamamoto M

更新日期：1998-08-03 00:00:00

abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...

journal_title：Brain research

authors： Baum L,Masliah E,Iimoto DS,Hansen LA,Halliday WC,Saitoh T

更新日期：1992-02-21 00:00:00

abstract：:Increasing evidence have shown that beta-amyloid (Abeta) induced hyperphosphorylation of tau, which eventually resulted in the disruption of microtubule (MT) integrity. Cyclin-dependent kinase 5 (CDK5) and its activator p35 are required for neurite outgrowth. The cleavage of p35 to p25, mediated by calpain and calcium...

journal_title：Brain research

authors： Chen X,Huang T,Zhang J,Song J,Chen L,Zhu Y

更新日期：2008-03-20 00:00:00

abstract：:In vivo release of labeled serotonin ([3H]5-HT) from the parietal cortex was investigated by cortical cup technique and electrical stimulation of midbrain raphe in rats anesthetized with pentobarbital sodium. The spontaneous efflux of tritium from the parietal cortex preload with [3H]5-HT followed a multiphasic expone...

journal_title：Brain research

authors： Fujiwara H,Uemoto M,Tanaka C

更新日期：1981-07-20 00:00:00

abstract：:Previous research has shown that hippocampal and neocortical activation accompanies the postural changes occurring during self-grooming in rats but is absent or reduced during the stereotyped components of grooming, including head-washing and licking or biting. Since electrocortical activation is dependent on ascendin...

journal_title：Brain research

authors： Robertson BJ,Boon F,Cain DP,Vanderwolf CH

更新日期：1999-08-14 00:00:00

abstract：:The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...

journal_title：Brain research

authors： Rotter A,Frostholm A

更新日期：1988-03-15 00:00:00

abstract：:Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...

journal_title：Brain research

authors： Aras R,Barron AM,Pike CJ

更新日期：2012-04-23 00:00:00

abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...

journal_title：Brain research

authors： Altobelli GG,Cimini V

更新日期：2007-02-09 00:00:00

abstract：:The effects of different adrenoceptor agonists were investigated on mechanically induced Ca2+ waves in astroglial cells in astroglial-neuronal mixed cultures from rat hippocampus. In the initial part of the study some properties of the waves were characterized. The results show that the initiation of the Ca2+ waves wa...

journal_title：Brain research

authors： Muyderman H,Nilsson M,Blomstrand F,Khatibi S,Olsson T,Hansson E,Rönnbäck L

更新日期：1998-05-18 00:00:00

abstract：:Microinjection of apomorphine into the ventral tegmental area (VTA) of male rats was previously shown to delay the onset of copulation and slow its rate, presumably by stimulating impulse-regulating autoreceptors on cell bodies of the A10 mesocorticolimbic dopamine tract. Such stimulation would be expected to slow the...

journal_title：Brain research

authors： Hull EM,Weber MS,Eaton RC,Dua R,Markowski VP,Lumley L,Moses J

更新日期：1991-07-19 00:00:00

abstract：:Previous electrophysiological as well as imaging research has contributed to the understanding of impairments in attention, executive functions, and memory in patients with attention-deficit/hyperactivity disorder (ADHD). However, there is a lack of studies investigating ADHD related differences in the gamma range of ...

journal_title：Brain research

authors： Lenz D,Krauel K,Schadow J,Baving L,Duzel E,Herrmann CS

更新日期：2008-10-15 00:00:00

abstract：:Nuclear factor kappa B (NFkappaB) is a transcription factor which can be activated by some neurotrophic factors and cytokines, and then translocated into the nucleus. We examined NFkappaB immunoreactivity (IR) in L4 and L5 dorsal root ganglion (DRG) cells of normal rats, and 2 weeks after complete sciatic nerve transe...

journal_title：Brain research

authors： Ma W,Bisby MA

更新日期：1998-06-29 00:00:00

abstract：:Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...

journal_title：Brain research

authors： Ichinose M,Byrne JH

更新日期：1991-05-17 00:00:00

abstract：:An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon or...

journal_title：Brain research

authors： Scott JJ,Davies P,Petit J

更新日期：1995-10-30 00:00:00

abstract：:Unilateral 6-hydroxydopamine (6-OHDA) lesions of substantia nigra pars compacta (SNPC) neurons in rats induce behavioural hypersensitivity to dopaminergic agonists. However, the role of specific dopamine receptors is unclear, and potential alterations in their transduction mechanisms remain to be evaluated. The presen...

journal_title：Brain research

authors： Newman-Tancredi A,Cussac D,Brocco M,Rivet JM,Chaput C,Touzard M,Pasteau V,Millan MJ

更新日期：2001-11-30 00:00:00