Morphological evidence of alteration in myelinstructure with maturation.

abstract：:We investigated the effect of high dose tetrodotoxin (TTX) on microdialysis measurements of extracellular striatal glutamate and dopamine in normal female rats. Both halothane-anesthetized rats with acutely implanted microdialysis probes and awake rats with microdialysis probes implanted for 24 h were tested. Glutamat...

journal_title：Brain research

authors： Shiraishi M,Kamiyama Y,Hüttemeier PC,Benveniste H

更新日期：1997-06-13 00:00:00

abstract：:Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...

journal_title：Brain research

authors： Ye L,Wang F,Yang RH

更新日期：2011-09-09 00:00:00

abstract：:Analysis of rat hypothalamic extracts by gel filtration and HPLC revealed the presence of a form of substance P-like immunoreactivity with a molecular weight of approximately 5,700 (6k-SP). 6k-SP is probably an N-terminally extended form of substance P; the peptide may be an intermediate in SP biosynthesis, or may fun...

journal_title：Brain research

authors： Harmar AJ,Armstrong A,Lee CM,Emson PC

更新日期：1984-12-10 00:00:00

abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...

journal_title：Brain research

authors： Maida ME,Hurley SD,Daeschner JA,Moore AH,O'Banion MK

更新日期：2006-08-04 00:00:00

abstract：:The response of trunk neural crest cells taken from precise levels of the neural axis and cultured together with adjacent somites to Brain-derived neurotrophic factor (BDNF), was examined in cultures grown in a chemically defined medium. In control cultures, the number of neural crest-derived neurons expressing the HN...

journal_title：Brain research

authors： Kalcheim C,Gendreau M

更新日期：1988-06-01 00:00:00

abstract：:The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher t...

journal_title：Brain research

authors： Fenske M,Wuttke W

更新日期：1976-03-05 00:00:00

abstract：:The technique of intracranial microdialysis was used to investigate the effects of aging on the striatal dopaminergic system of the anesthetized Fischer 344 rat. Microdialysis probes were implanted into the striatum of young (2-8 months) and aged (24-28 months) urethane anesthetized rats. Striatal dialysate levels wer...

journal_title：Brain research

authors： Gerhardt GA,Maloney RE Jr

更新日期：1999-01-16 00:00:00

abstract：:The neocortex has proven resistant to LTP induction using standard in vitro and acute, in vivo preparations. Because the neocortex is widely thought to be involved in long-term information storage, this resistance raises questions about the validity of LTP as a memory model. Recently, we have shown that the neocortex ...

journal_title：Brain research

authors： Boyd TE,Trepel C,Racine RJ

更新日期：2000-10-20 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common forms of dementia with still unknown pathogenesis. Several cytokines and chemokines are involved in the pathogenesis of AD. Among the chemokines, the CXCR4/CXCL12 complex has been shown to play an important role in the pathogenetic development of AD. We investigated t...

journal_title：Brain research

authors： Sanfilippo C,Castrogiovanni P,Imbesi R,Nunnari G,Di Rosa M

更新日期：2020-12-15 00:00:00

abstract：:Systemic administration of kainic acid in the rat results in the development of a characteristic excitotoxic syndrome, consisting of automatisms (wet dog shakes, WDS), sustained limbic seizures and brain damage. Since kainate increases the release of excitatory amino acid neurotransmitters such as glutamate, this synd...

journal_title：Brain research

authors： Baran H,Löscher W,Mevissen M

更新日期：1994-08-01 00:00:00

abstract：:In over half a century numerous studies have demonstrated that different odorants produce individually different spatial patterns of neural receptor activity on the olfactory mucosa. However, the thought that these differential activity patterns could be the neural code underlying olfactory perception has not been tes...

journal_title：Brain research

authors： Kent PF,Mozell MM,Youngentob SL,Yurco P

更新日期：2003-08-15 00:00:00

abstract：:Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...

journal_title：Brain research

authors： Allan AM,Zhang X,Baier LD

更新日期：1992-08-21 00:00:00

abstract：:The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...

journal_title：Brain research

authors： Nabeshima T,Matsuno K,Kameyama T

更新日期：1985-09-16 00:00:00

abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...

journal_title：Brain research

authors： Passani LA,Vonsattel JP,Coyle JT

更新日期：1997-10-24 00:00:00

abstract：:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...

journal_title：Brain research

authors： Radja F,Descarries L,Dewar KM,Reader TA

更新日期：1993-03-26 00:00:00

abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...

journal_title：Brain research

authors： Andres-Mach M,Haratym-Maj A,Zagaja M,Rola R,Maj M,Chrościńska-Krawczyk M,Luszczki JJ

更新日期：2015-10-22 00:00:00

abstract：:Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...

journal_title：Brain research

authors： Crow T,Pengidore T

更新日期：1993-11-19 00:00:00

abstract：:Perineal muscles essential for copulatory functioning are innervated by Onuf's nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous st...

journal_title：Brain research

authors： Polak K,Freeman LM

更新日期：2010-07-30 00:00:00

abstract：:We have previously shown that blockade of neurotransmission mediated by gamma-aminobutyric acid (GABA) in the ventromedial nucleus of the hypothalamus (VMH) by the microinjection of a GABAA receptor antagonist, bicuculline methiodide (BM), exclusively induced running activity in the rat. The purpose of the present stu...

journal_title：Brain research

authors： Narita K,Yokawa T,Nishihara M,Takahashi M

更新日期：1993-02-19 00:00:00

abstract：:Metallothioneins (MTs) are metal-binding proteins that are expressed in many tissues including brain. MTs protect cells and organs against metal toxicity and oxidants. Among MTs, a brain-predominant subtype MT-III has prominent neuroprotective activity against various types of damage. Here we show that the expression ...

journal_title：Brain research

authors： Tanji K,Irie Y,Uchida Y,Mori F,Satoh K,Mizushima Y,Wakabayashi K

更新日期：2003-06-20 00:00:00

abstract：:When one eye of a rat is removed at birth an increased projection to the brain is found from the remaining eye. This projection arises from the whole retina and mainly from ganglion cells which project to only one hemisphere of the brain. In the normal course of development many of these cells die and the uncrossed pr...

journal_title：Brain research

authors： Jeffery G,Perry VH

更新日期：1981-08-01 00:00:00

abstract：:Because brainstem auditory evoked potentials (BAEPs) are frequently recorded in anesthetized animals and humans, it is important to become familiar with the effects on the BAEP of drugs used during anesthesia, including pre-anesthetics. The dose-dependent and stimulus intensity-dependent effects on the BAEP of a pre-a...

journal_title：Brain research

authors： Church MW,Gritzke R

更新日期：1988-07-26 00:00:00

abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

journal_title：Brain research

authors： Sabol KE,Seiden LS

更新日期：1998-09-21 00:00:00

abstract：:Using an isolated neonatal rat spinal cord preparation, we have studied the ability of hydrogen peroxide to act as a source of oxygen for mammalian central nervous system (CNS) maintained in vitro. We report here that hydrogen peroxide, in low concentrations (0.001-0.004%), can effectively provide the only source, or ...

journal_title：Brain research

authors： Walton K,Fulton B

更新日期：1983-11-14 00:00:00

abstract：:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...

journal_title：Brain research

authors： Emch GS,Hermann GE,Rogers RC

更新日期：2002-10-04 00:00:00

abstract：:We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...

journal_title：Brain research

authors： Chi SI,Levine JD,Basbaum AI

更新日期：1993-07-23 00:00:00

abstract：:Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine...

journal_title：Brain research

authors： Quatacker J,Partoens P,De Potter W

更新日期：1998-08-17 00:00:00

abstract：:The existence of monosynaptic contacts between primary afferents and motoneurons in the lumbar spinal cord of the turtle Pseudemys scripta elegans was demonstrated by intracellular injections of horseradish peroxidase. Three afferent-motoneuron combinations were satisfactorily labeled and revealed 1, 4 and 6 contacts ...

journal_title：Brain research

authors： Ruigrok TJ,Crowe A,ten Donkelaar HJ

更新日期：1985-07-22 00:00:00

abstract：:These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...

journal_title：Brain research

authors： Laurenzana EM,Owens SM

更新日期：1997-05-09 00:00:00

abstract：:Amyloid β-protein (Aβ) is the major component of extracellular plaques in the brains of patients with Alzheimer's disease. It has been suggested that the interaction of Aβ with membrane cholesterol is essential for Aβ to exert neurotoxicity; however, the effect of phospholipids, another major membrane lipid component,...

journal_title：Brain research

authors： Ko M,Hattori T,Abdullah M,Gong JS,Yamane T,Michikawa M

更新日期：2016-07-01 00:00:00