Abstract：
:Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine splenic axons in vitro and compared with terminals in the vas deferens. In the synaptic differentiations taking place proximally synapsin could only be detected on the accumulating elements of the axonal reticulum. Large dense granules and clusters of small synaptic vesicles were negative. Synaptophysin was restricted to these clusters. In the vas deferens, co-localization of synapsin and synaptophysin could be seen on small vesicles. From their formation small synaptic vesicles carry synaptophysin. Synapsin may be involved in the dynamic membrane changes taking place at the ligation. At a functional terminal, synapsin shifts to small synaptic vesicles.
journal_name
Brain Resjournal_title
Brain researchauthors
Quatacker J,Partoens P,De Potter Wdoi
10.1016/s0006-8993(98)00617-9subject
Has Abstractpub_date
1998-08-17 00:00:00pages
281-4issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00617-9journal_volume
802pub_type
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