Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord.


:We have evaluated changes in the expression of neurotrophin-3 (NT-3) and its tyrosine kinase C (TrkC) receptor in the neuromuscular system as a result of voluntary physical activity. We assessed changes in the mRNAs and proteins for NT-3 and TrkC in the lumbar spinal cord and associated soleus muscle following 3 and 7 days of voluntary wheel running. We used quantitative Taqman RT-PCR to measure mRNA and ELISA to assess protein levels. NT-3 mRNA and protein levels increased in the spinal cord to reach statistical significance after 7 days of exercise compared to sedentary control rats. Immunohistochemical analyses localized the elevated NT-3 to the substantia gelatinosa (SG) and nucleus of the dorsal horn. TrkC mRNA levels were significantly elevated in the spinal cord after 3 and 7 days of running. In the soleus muscle, NT-3 mRNA levels and its receptor TrkC were elevated after 3 days, while NT-3 protein levels remained unaffected. The results demonstrate that voluntary exercise has a differential effect on NT-3 as well as its receptor TrkC in the neural and muscular components of the neuromuscular system, and emphasize the role of voluntary activity on the spinal cord and muscle.


Brain Res


Brain research


Ying Z,Roy RR,Edgerton VR,Gómez-Pinilla F




Has Abstract


2003-10-10 00:00:00














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    abstract::Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glosso...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ichikawa H,Lin SC,Tsai SY,Tsai MJ,Sugimoto T

    更新日期:2004-07-16 00:00:00

  • Adaptive plasticity in the primate spinal stretch reflex: reversal and re-development.

    abstract::Monkeys can gradually increase or decrease the amplitude of the segmentally mediated spinal stretch reflex (SSR) without change in initial muscle length or background EMG activity. Both increase (under the SSR increases mode) and decrease (under the SSR decreases mode) occur slowly, progressing steadily over weeks. Th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wolpaw JR

    更新日期:1983-11-14 00:00:00

  • Regeneration of gamma-fusimotor axons after nerve-freeze injury in the cat.

    abstract::Nerve injury was produced by application of dry ice to the common peroneal nerve. After 20 weeks, muscle-spindle primary endings responded normally to stretch and the spindles were found to have a fully functional fusimotor innervation. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Scott JJ

    更新日期:1985-11-25 00:00:00

  • Conductance changes during bath application of beta-alanine and taurine in giant interneurons of the isolated lamprey spinal cord.

    abstract::(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a com...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Homma S

    更新日期:1979-09-14 00:00:00

  • Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole-kindled rats.

    abstract::The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A

    更新日期:2010-06-25 00:00:00

  • Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the rat.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Robledo P,Maldonado R,Koob GF

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  • Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components.

    abstract::Immunofluorescence on primary dissociated rat neuronal cultures (cortical, hippocampal, and cerebellar) and organotypic hippocampal cultures was used to investigate the pattern of distribution of cell-surface amyloid protein (APP). Antibodies directed against the extracellular (N-terminal) portion of APP or against th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Storey E,Beyreuther K,Masters CL

    更新日期:1996-10-07 00:00:00

  • Retinotopic organizations of the expanded ipsilateral projection to the rat's superior colliculus; variations along its rostrocaudal axis.

    abstract::The retinotopic organization of the expanded projection to the ipsilateral colliculus was studied electrophysiologically in 12 adult albino rats with one eye removed at birth. For comparison, the contralateral projection was rather variable in the representation of the nasotemporal axis of the retina along the rostroc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fukuda Y,Hsiao CF,Sawai H,Wakakuwa K

    更新日期:1984-11-12 00:00:00

  • Lectin affinity and PAGE analysis of soluble axonally transported glycoconjugates in the rat visual system.

    abstract::Recent reports of the transsynaptic transfer of wheat germ agglutinin (WGA) in several systems are consistent with the hypothesis that WGA binds to endogenous glycoproteins(s) which undergo transsynaptic transfer. Such molecules might be involved in trophic interactions between neurons. Since these hypothetical glycop...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rhodes CH,Gonatas NK

    更新日期:1986-12-03 00:00:00

  • Afferent pain pathways: a neuroanatomical review.

    abstract::Painful experience is a complex entity made up of sensory, affective, motivational and cognitive dimensions. The neural mechanisms involved in pain perception acts in a serial and a parallel way, discriminating and locating the original stimulus and also integrating the affective feeling, involved in a special situati...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Almeida TF,Roizenblatt S,Tufik S

    更新日期:2004-03-12 00:00:00

  • Role of the amygdala in ethanol withdrawal seizures.

    abstract::Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Feng HJ,Yang L,Faingold CL

    更新日期:2007-04-13 00:00:00

  • Activation of neuroblast proliferation in explant culture of the Drosophila larval CNS.

    abstract::The developmental control of neuroblast proliferation is absolutely required for the assembly and function of the central nervous system. A lethal mutation in trol results in the failure of quiescent neuroblasts to begin division at the appropriate time. I have established a culture system in which quiescent neuroblas...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Datta S

    更新日期:1999-02-06 00:00:00

  • An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

    abstract::Stroke is the major cause of acquired epilepsy in the adult population. The mechanisms of ischemia-induced epileptogenesis are not completely understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis. The objective of this study was to develop an in vitro model of epileptogenesis in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ziobro JM,Deshpande LS,Delorenzo RJ

    更新日期:2011-01-31 00:00:00

  • Postsynaptic effects of DMSO at the frog neuromuscular junction.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cherki-Vakil R,Meiri H

    更新日期:1991-12-06 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakao S,Curthoys IS,Markham CH

    更新日期:1980-02-10 00:00:00

  • Ultrastructural organization of receptor cell axons in frog olfactory nerve.

    abstract::Repeated odorant or electrical stimulation of the frog olfactory nerve leads to long-lasting reduction of excitability of the receptor neurons. In the turtle olfactory nerve electrical stimulation causes an increase in extracellular potassium concentration due to the efflux of potassium from active axons. Elevated pot...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Daston MM,Adamek GD,Gesteland RC

    更新日期:1990-12-24 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Williams AJ,Tortella FC

    更新日期:2002-04-05 00:00:00

  • Glycine cleavage system in astrocytes.

    abstract::The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sato K,Yoshida S,Fujiwara K,Tada K,Tohyama M

    更新日期:1991-12-13 00:00:00

  • Electrical stimulation reveals relatively ineffective sural nerve projections to dorsal horn neurons in the cat.

    abstract::Electrical stimulation of the sural nerve (SN) revealed input from sural nerve afferents to L6 and L7 dorsal horn neurons that were not apparent using natural mechanical stimuli, especially in cells with variable latency responses to SN stimulation. Nearly all (31/32) cells that had reliable, fixed latency responses t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pubols LM,Foglesong ME,Vahle-Hinz C

    更新日期:1986-04-16 00:00:00

  • Cutaneous hyperalgesia induced by peripheral injection of interleukin-1 beta in the rat.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fukuoka H,Kawatani M,Hisamitsu T,Takeshige C

    更新日期:1994-09-19 00:00:00

  • Motion illusion activates the visual motion area of the brain: a near-infrared spectroscopy (NIRS) study.

    abstract::Near-infrared spectroscopy (NIRS) enables noninvasive measurement of concentration changes of oxy- and deoxy-hemoglobin. The present study investigated cerebral representations of motion illusion by NIRS and examined several experimental procedures to determine an efficient procedure that can shorten the experimental ...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章


    authors: Hashimoto T,Minagawa-Kawai Y,Kojima S

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  • Evidence that diffuse noxious inhibitory controls (DNIC) are medicated by a final post-synaptic inhibitory mechanism.

    abstract::Nineteen convergent neurones, 19 'non-noxious only' neurones and 13 'proprioceptive' neurones all with peripheral excitatory receptive fields on the ipsilateral hindpaw, were recorded in the lumbar dorsal horn of non-spinalized, anaesthetized rats. These neurones were all excited by the electrophoretic application of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Villanueva L,Cadden SW,Le Bars D

    更新日期:1984-04-23 00:00:00

  • Regional localization of agmatine in the rat brain: an immunocytochemical study.

    abstract::The distribution of agmatine (decarboxylated arginine) was mapped in the central nervous system (CNS) in the rat. Agmatine-like immunoreactivity was identified by light microscopy, exclusively in the cytoplasm of neuronal perikarya. Immunoreactive neurons were present in the cerebral cortex, predominantly within lamin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Otake K,Ruggiero DA,Regunathan S,Wang H,Milner TA,Reis DJ

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  • Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis.

    abstract::The present study determined whether cortical cholinergic neurons recover functionally following the loss of afferent projections from the nucleus basalis magnocellularis (nbm). At various time points following ibotenic acid lesions of the nbm, choline acetyltransferase (ChAT) activity or the capacity of cortical chol...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lapchak PA,Araujo DM,Pasinetti G,Hefti F

    更新日期:1993-06-11 00:00:00

  • Inhibition of the soleus H-reflex in standing man.

    abstract::There exists evidence to support the notion that the segmental reflex system is not fixed and inflexible, but rather is highly modifiable under a variety of circumstances. In this study the H-wave and M-wave recruitment curves were obtained from 19 subjects, utilizing the procedures outlined by Hugon. Each subject was...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Koceja DM,Trimble MH,Earles DR

    更新日期:1993-11-26 00:00:00

  • Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice.

    abstract::Focal cerebral ischemia elicits an inflammatory response characterized by the infiltration and accumulation of leukocytes, as well as the secretion of inflammatory mediators (Clark et al., Brain Res. Bull., 35 (1994) 387-392; Garcia et al., Am. J. Pathol., 144 (1994) 188-199; Wang et al., J. Neurochem. 71 (1998) 1194-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Che X,Ye W,Panga L,Wu DC,Yang GY

    更新日期:2001-06-01 00:00:00

  • GABAergic inhibition and the induction of spontaneous epileptiform activity by low chloride and high potassium in the hippocampal slice.

    abstract::Intracellular recordings from CA3b/c neurons in rat hippocampal slices showed that reduction of the extracellular Cl- concentration from 136 to 53 mM produced a positive (+10 mV) shift in the reversal potential of GABAergic inhibitory postsynaptic potentials (IPSPs). This shift was not significantly different from the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chamberlin NL,Dingledine R

    更新日期:1988-03-29 00:00:00

  • Adhesion of neural cells to extracellular matrix constituents. Involvement of glycosaminoglycans and cell adhesion molecules.

    abstract::Single cell suspensions of early postnatal mouse cerebellum adhere to substrate-bound culture supernatants of the teratocarcinoma cell line PF-HR9 and can be inhibited to adhere by antibodies to the neural cell adhesion molecules L1 and N-CAM. Adhesion can also be inhibited by the glycosaminoglycans heparin and hepara...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Werz W,Schachner M

    更新日期:1988-10-01 00:00:00

  • Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.

    abstract::Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamamoto Y,Hosoda K,Imahori T,Tanaka J,Matsuo K,Nakai T,Irino Y,Shinohara M,Sato N,Sasayama T,Tanaka K,Nagashima H,Kohta M,Kohmura E

    更新日期:2018-05-15 00:00:00

  • Intra-amygdalar okadaic acid enhances conditioned taste aversion learning and CREB phosphorylation in rats.

    abstract::Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Oberbeck DL,McCormack S,Houpt TA

    更新日期:2010-08-12 00:00:00