Abstract:
:The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher than in untreated control rats. Intraventricular injection of male rats with artificial cerebrospinal fluid resulted in elevated mean prolactin levels similar to those observed in 6-OHDA-treated animals. Further experimentation on animals decapitated at different times after removal from the animal quarters, indicates that prolcatin levels in 6-OHDA-treated rats are continuously elevated whereas they rise from basal levels to extremely high levels in CSF-treated rats, thus resulting in similar mean values. The CSF-treated controls ate hypersensitive to the stress of being removed from their normal environment. Such an effect was not observed in 6-OHDA-treated nor in untreated, and thus stress-inexperienced rats. In a long term study, serum prolactin and luteinizing hormone (LH) levels were followed over a period of 71 days after 6-OHDA treatment. Prolactin levels increased within one day after treatment and stayed at a high level for 15 days. Subnormal prolactin values were measured 37 days after 6-OHDA treatment. Serum LH levels were below normal 3 h and one day and were increased 37 and 71 days after 6-OHDA treatment. These results suggest that NE is important in the transmission of stressful stimuli to hypothalamic prolactin regulating centers. They further suggest functional recovery of LH and prolactin regulating mechanisms after 6-OHDA treatment.
journal_name
Brain Resjournal_title
Brain researchauthors
Fenske M,Wuttke Wdoi
10.1016/0006-8993(76)90647-8subject
Has Abstractpub_date
1976-03-05 00:00:00pages
63-70issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(76)90647-8journal_volume
104pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::We characterized acute intracerebral hemorrhage (ICH) in the rat by sequential magnetic resonance imaging (MRI) and correlated MRI findings with neurobehavior and histopathology. In addition, we investigated whether albumin treatment would reduce ICH-induced brain injury. ICH was produced in rats by a double-injection...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.077
更新日期:2007-07-09 00:00:00
abstract::Glycine is taken up twice as rapidly by neurons R3-R14 as by other identified neurons in the Aplysia parietovisceral ganglion. Earlier studies had shown that R3-R14 have much higher glycine concentrations than other Aplysia neurons. Most of the glycine taken up by R3-R14 was biochemically untransformed for at least 1 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)91049-1
更新日期:1978-10-06 00:00:00
abstract::We compared the laminar location and morphology of superior colliculus cells projecting to the dorsal and ventral lateral geniculate nuclei (LGd, LGv), the pretectum (PT), the parabigeminal nucleus (Pb), and nucleus lateralis posterior (LP) in the ground squirrel Spermophilus tridecemlineatus. Horseradish peroxidase w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90432-x
更新日期:1987-11-17 00:00:00
abstract::The distribution of nitric oxide synthase (NOS)-, choline acetyltransferase (ChAT)-, and vasoactive intestinal polypeptide (VIP)-immunoreactivities, and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd)-reactivities in the sphenopalatine ganglia (SPG), and perivascular nerves in middle cerebral arteries ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00548-4
更新日期:1998-08-10 00:00:00
abstract::Post-traumatic invasion of macrophages into the cochlear nerve of the rat and measurement of how their invasion was modified by the administration of methylprednisolone were investigated for the first time by using a reproducible and quantifiable experimental model of cochlear nerve injury. Two weeks after precise coc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02523-9
更新日期:2001-06-29 00:00:00
abstract::Cholecystokinin-octapeptide-like-immunoreactivity (CCK-8-LI) is demonstrable by the indirect immunofluorescent technique in cerebral cortical neurons cultured from fetal rats. Prominent and widespread staining is seen in widely ramifying cellular processes throughout the cultures. Staining in neuronal cell bodies is e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91456-2
更新日期:1984-02-13 00:00:00
abstract::Multiple sclerosis patients typically experience increased pain that is relatively insensitive to opiate treatment. The mechanistic basis for this increased nociception is currently poorly understood. In the present study, we utilized the Theiler's murine encephalomyelitis virus (TMEV) model of MS to examine possible ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.034
更新日期:2008-01-29 00:00:00
abstract::In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicated in the Alzheimer׳s disease (AD)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.09.036
更新日期:2015-12-10 00:00:00
abstract::The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent mann...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91331-a
更新日期:1990-08-13 00:00:00
abstract::The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91140-6
更新日期:1986-05-07 00:00:00
abstract::Rodent models of focal and global ischemia were used to examine caspase activation. Several readouts were employed on identical tissue to provide correlative measurement of caspase induction, activation and enzymatic activity. In a rat focal ischemia model, caspase-3 enzymatic activity, as recorded by DEVD-AMC cleavag...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02846-4
更新日期:2003-08-29 00:00:00
abstract::The participation of amygdaloid and striatal structures in the various signs of morphine withdrawal syndrome (MWS) has been investigated using two complementary approaches: intracerebral application of naloxone in various nuclei of dependent rats and effects of various lesions and transections on systemically induced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90915-6
更新日期:1979-11-09 00:00:00
abstract::The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility that the graft-derived 5-HT hyperinnervation is governed by target-rela...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91667-4
更新日期:1992-10-02 00:00:00
abstract::Previous research has shown that peripheral inflammation and peripheral nerve injury alter the properties of NMDA receptors in the spinal dorsal horn. However, there is no direct evidence that demonstrates the influence of peripheral nerve injury on NMDA receptor-mediated synaptic transmission in the spinal dorsal hor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.12.014
更新日期:2007-03-02 00:00:00
abstract::The 2009 influenza A(H1N1) pandemic led to a particularly high risk of morbidity and mortality among pregnant women. Therefore, inactivated influenza vaccines have been widely recommended for women in any period of gestation. Recent studies have shown that the peripheral adaptive immune system plays an important role ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.076
更新日期:2014-12-10 00:00:00
abstract::Discrete axon-sparing lesions were placed unilaterally in the mesencephalon by the local injection of kainic acid. Unilateral lesions of the dorsal reticular formation just beneath the superior colliculus and lateral to the periacqueductal grey resulted in consistent ipsiversive apomorphine-induced circling. Only weak...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90579-5
更新日期:1981-03-16 00:00:00
abstract::Rhythmic caffeine hyperpolarizations generated in bullfrog sympathetic ganglion cells are assumed to be caused by periodic increase in gK due to rise in [Ca2+]i7--9,13. Caffeine-induced outward currents seem to be composed of two different components, which show different pharmacological natures and also different dep...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90263-3
更新日期:1982-07-15 00:00:00
abstract::The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91114-t
更新日期:1992-09-11 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been described to have a role in the modulation of various genes involved in Abeta homeostasis, inflammation, and energy metabolism, making it a candidate gene for risk of Alzheimer's disease (AD). A functional polymorphism in exon 2 of the PPAR-gamma g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.07.034
更新日期:2009-09-29 00:00:00
abstract::Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02014-x
更新日期:2000-03-31 00:00:00
abstract::The blood-brain barrier (BBB) prevents many drugs from entering the brain. Yet, conventional methods that open the BBB are technically demanding, poorly reversible, and can be associated with long-term adverse effects. In comparison, carbogen, which is introduced nearly a century ago as a treatment for psychiatric dis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146320
更新日期:2019-10-01 00:00:00
abstract::An in vitro method was developed to separately visualize dopaminergic, noradrenergic and serotoninergic terminals in the cerebral, hippocampal and cerebellar cortices of the rat, by means of the glyoxylic histochemical fluorescence method. Animals were pretreated with alpha-methylparatyrosine to deplete catecholamine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90770-9
更新日期:1978-05-19 00:00:00
abstract::Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90180-4
更新日期:1985-10-01 00:00:00
abstract::Using the monoclonal antibody G2-09 raised against bovine glia maturation factor (GMF), we demonstrated that cultured rat Schwann cells and Schwannoma cells, but not their conditioned media, possessed endogenous GMF-like immunoreactivity. The presence of immunoreactive GMF correlated well with GMF bioactivity. The GMF...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90140-x
更新日期:1988-05-16 00:00:00
abstract::The hypothesis that inhibition of nitric oxide (NO) synthase with subsequent decrease in the production of NO might attenuate the development of kappa-opiate tolerance was examined. Concurrent treatment of NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA) (2-8 mg/kg, i.p.) along with U-50,488H (25 mg/kg, i.p.) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90316-f
更新日期:1993-09-03 00:00:00
abstract::Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02339-2
更新日期:2000-01-31 00:00:00
abstract::The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90019-8
更新日期:1987-09-01 00:00:00
abstract::It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01101-3
更新日期:1998-01-01 00:00:00
abstract::Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.001
更新日期:2017-11-15 00:00:00
abstract::We used double staining immunocytochemical techniques to determine whether nitric oxide (NO) and Fos immunoreactivity induced by noxious visceral stimulation were colocalized in the neurons of the supraspinal areas. We observed a considerable increase in Fos-positive neurons in many brain areas after noxious stimulati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01434-1
更新日期:1999-07-10 00:00:00