Abstract：
:It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an in vitro superfusion technique. To accomplish this goal, NE output from the OB of intact and castrated male rats in response to infusion with two different drugs which alter NE uptake functions, tomoxetine and talsupram, were tested. Overall, NE outputs in response to tomoxetine were significantly higher in the castrated than in intact rats and both groups were significantly greater than non-infused controls. For the talsupram infusion group, NE outputs from the castrated, but not intact rats, were significantly greater than controls. No statistically significant differences were detected between the castrated and intact rats. These results demonstrate that castration alters the NE uptake activities in response to these noradrenergic uptake blockers and suggest that one mechanism by which castration alters OB-NE functioning is through reducing the uptake activity of NE within the OB. Such findings have important implications for olfactory-based learning and memory/recognition processes which are believed to involve the OB-NE system and are altered following castration.
journal_name
Brain Resjournal_title
Brain researchauthors
Shang Y,Dluzen DEdoi
10.1016/s0006-8993(97)01101-3subject
Has Abstractpub_date
1998-01-01 00:00:00pages
119-24issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01101-3journal_volume
779pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91124-7
更新日期：1984-07-02 00:00:00
abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.058
更新日期：2015-02-19 00:00:00
abstract：:Effects of intracellular accumulation of 3',5'-cyclic adenosine monophosphate (cAMP) were studied using 3',5'-cyclic 8-bromoadenosine monophosphate (8-Br-cAMP) and forskolin on single motoneurons acutely dissociated from adult bullfrog spinal cord. 8-Br-cAMP (10(-3) M) and forskolin (1.5 x 10(-6) M) activated inward c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90787-a
更新日期：1992-02-28 00:00:00
abstract：:Increased permeability of the brain-blood barrier (BBB) in the piriform cortex (PC) has been reported in various animal models of temporal lobe epilepsy. Since BBB disruption induced by epileptogenic insult has not fully clarified, we attempted to determine whether changes in BBB-related molecules are associated with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.080
更新日期：2011-01-19 00:00:00
abstract：:Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90428-e
更新日期：1990-04-23 00:00:00
abstract：:In previous studies we found that in the extremely polydipsic special strain of mice, STR/N, spontaneous drinking was greatly attenuated by injection of the opioid antagonists given intracerebroventricularly as well as subcutaneously. Therefore, we investigated, using hypothalamic slice preparations, responses of neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90441-w
更新日期：1991-01-11 00:00:00
abstract：:Two distinct patterns of terminal labeling were seen after injections of [3H]amino acids into the second somatosensory area (S2) and the retroinsular area (Ri). The first pattern, seen both in S2 after an injection in Ri and in the granular or dysgranular insular fields after an injection in S2, is characterized by he...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91103-4
更新日期：1983-08-22 00:00:00
abstract：:Previous studies have demonstrated that increased mesolimbic dopamine (DA) activity disrupts sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Other behavioral changes following mesolimbic DA activation are mediated through GABAergic efferent projections from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91754-5
更新日期：1990-11-05 00:00:00
abstract：:We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.113
更新日期：2006-04-12 00:00:00
abstract：:Many of our daily movements use visual information to guide our arms toward objects of interest. Typically, these visually guided movements involve first focusing our gaze on the intended target and then reaching toward the direction of our gaze. The literature on eye-hand coordination provides a great deal of evidenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.057
更新日期：2009-08-11 00:00:00
abstract：:One hundred and four visual units of the (ventral) lateral geniculate nucleus (GL) of chicks (Gallus domesticus) were studied with extracellular microelectrodes. Most were extremely responsive to moving targets even at low speeds (0.1 degrees/sec). They were classified as follows. (1) movement-sensitive units with uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90823-0
更新日期：1979-05-11 00:00:00
abstract：:This study was designed to elucidate the origin of norepinephrine (NE) measured in spinal cord following trauma. In normal cats the NE concentration at the lesion site increased 63% over control 1 h following experimentally produced blunt trauma (400 g-cm). Spinal cords of adrenalectomized cats were also traumatized, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90536-9
更新日期：1976-06-11 00:00:00
abstract：:In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic studies and measured cortical nitric oxide synth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02471-9
更新日期：2000-07-21 00:00:00
abstract：:Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91585-o
更新日期：1991-03-01 00:00:00
abstract：:GABA levels, high affinity GABA uptake and glutamic acid decarboxylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is al...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90693-4
更新日期：1981-02-23 00:00:00
abstract：:We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90137-4
更新日期：1987-03-01 00:00:00
abstract：:We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT3R). Quantitative analysis indicated that more than 90% of 5-HT3R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT3R and GABA in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00557-4
更新日期：1996-08-26 00:00:00
abstract：:The purpose of the present study is to examine the effects of mental fatigue and motivation on neural network dynamics activated during task switching. Mental fatigue was induced by 2 h of continuous performance; after which subjects were motivated by using social comparison and monetary reward as motivating factors t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.015
更新日期：2009-05-13 00:00:00
abstract：:Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91197-x
更新日期：1980-01-27 00:00:00
abstract：:Endogenous calcitonin was altered in rats by thyroparathyroidectomy, followed by supplementation with thyroxine and calcium. As a result, a reduction in the content of 5-hydroxytryptamine in the brain together with an increase in the concentration of tryptophan in the plasma were observed. The changes were accompanied...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90129-9
更新日期：1982-04-29 00:00:00
abstract：:The relationship between the dorsal raphe neurons projecting to the caudate-putamen and those projecting to the substantia nigra was investigated using a fluorescent retrograde double labeling technique in the rat. The majority of the dorsal raphe neurons projecting to the substantia nigra were found to project also t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90250-4
更新日期：1980-03-17 00:00:00
abstract：:We studied the effects of axotomy or neurotoxin on the survival of substantia nigra pars compacta (SNpc) neurons in two strains of mice, FVB/N or C57BL/6. Fluoro gold (FG) was injected into both striata of the mice to retrogradely label the nigrostriatal neuronal population. Ten days later, these neurons were axotomiz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.066
更新日期：2003-12-24 00:00:00
abstract：:The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91037-2
更新日期：1991-02-15 00:00:00
abstract：:We previously reported that angiotensin II type 2 (AT(2)) receptor signaling prevents neural damage and cognitive impairment after focal cerebral ischemia. We investigated the possible roles of the AT(2) receptor in the sex difference, focusing on cognitive function and ischemic brain damage using AT(2) receptor-defic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.068
更新日期：2009-12-01 00:00:00
abstract：:Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90628-2
更新日期：1988-12-20 00:00:00
abstract：:Previous studies have demonstrated a higher mean peak frequency of the hippocampal (HPC) theta rhythm during REM sleep in alcohol-nonpreferring (NP) rats when compared with alcohol-preferring (P) rats. Burst firing neurons of the medial septal area (MS/VDB) are thought to pace the HPC theta rhythm during REM sleep and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01520-5
更新日期：1996-04-01 00:00:00
abstract：:Endoplasmic reticulum (ER) and mitochondria dysfunction contribute to insulin resistance generation during obesity and diabetes. ER and mitochondria interact through Mitofusin 2 (MTF2), which anchors in the outer mitochondrial and ER membranes regulating energy metabolism. Ablation of MTF2 leads to ER stress activatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.09.014
更新日期：2015-11-19 00:00:00
abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.035
更新日期：2004-12-17 00:00:00
abstract：:Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03125-0
更新日期：2001-12-07 00:00:00
abstract：:The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil. Contributions of semicircular canal versus otolith organ signals were investigated by providing a canal only (ve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02505-8
更新日期：2003-05-16 00:00:00
