Abstract:
:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene that is characterized by progressive action tremor, gait ataxia, and cognitive decline. Recent studies of mitochondrial dysfunction in FXTAS have suggested that iron dysregulation may be one component of disease pathogenesis. We tested the hypothesis that iron dysregulation is part of the pathogenic process in FXTAS. We analyzed postmortem choroid plexus from FXTAS and control subjects, and found that in FXTAS iron accumulated in the stroma, transferrin levels were decreased in the epithelial cells, and transferrin receptor 1 distribution was shifted from the basolateral membrane (control) to a predominantly intracellular location (FXTAS). In addition, ferroportin and ceruloplasmin were markedly decreased within the epithelial cells. These alterations have implications not only for understanding the pathophysiology of FXTAS, but also for the development of new clinical treatments that may incorporate selective iron chelation.
journal_name
Brain Resjournal_title
Brain researchauthors
Ariza J,Steward C,Rueckert F,Widdison M,Coffman R,Afjei A,Noctor SC,Hagerman R,Hagerman P,Martínez-Cerdeño Vdoi
10.1016/j.brainres.2014.11.058subject
Has Abstractpub_date
2015-02-19 00:00:00pages
88-96eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01665-5journal_volume
1598pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham denervation (SHAM) and then fitted with a chronic guide cannula into the lateral cerebral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.110
更新日期:2010-12-17 00:00:00
abstract::In larval lamprey 4 weeks after a spinal transection locomotor patterns were usually complete along the body in whole animals. In in vitro preparations locomotor activity was restricted to a few millimeters below the transection. Retrograde labeling indicated that descending axons from a few brainstem neurons had grow...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90252-i
更新日期:1993-01-29 00:00:00
abstract::This study examined the temporal appearance of c-fos expression in rat cerebella from birth to postnatal day 21 (P21) and following systemic kainic acid administration in adults. During development, Fos positive granule cells appeared first at P3 in caudal lobules and extended to all folia by P9. These reactive cells ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00263-7
更新日期:1998-06-08 00:00:00
abstract::The effects of intracerebroventricular injections of 8-OH-DPAT (a 5-HT1A agonist; 3, 15 or 30 nmol) or GR46611 (a 5-HT1B/1D agonist; 3, 15 or 30 nmol) on feeding, drinking, preening and sleep-like behaviors were investigated in free-feeding (FF) pigeons. The effects of these 5-HT agonists on blood glucose and free fat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.031
更新日期:2004-11-12 00:00:00
abstract::The organization and representation of conceptual knowledge in the brain remains a controversial issue in terms of both neuropsychological and imaging evidence. We report the results of a functional magnetic resonance study in which the role of the most debated dimensions (domain and feature type) was evaluated throug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.070
更新日期:2008-02-15 00:00:00
abstract::Deferoxamine (DFO) has shown therapeutic promise for the treatment of Parkinson׳s disease (PD) as it has reduced both behavioral and biochemical deficits when injected into the brain of rodent models of PD. Intranasally administered DFO targets the brain directly but non-invasively and has been effective in animal mod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.05.048
更新日期:2014-07-29 00:00:00
abstract::The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91318-1
更新日期:1986-02-26 00:00:00
abstract::Olfactory nerve input is required for the normal expression of tyrosine hydroxylase (TH) by dopaminergic neurons in the glomerular region of the rodent main olfactory bulb. To determine whether the olfactory nerve exerts a similar influence on neurons in other brain regions, we performed unilateral bulbectomies in rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90977-3
更新日期:1989-09-11 00:00:00
abstract::Infusion of 15 micrograms/microliters (approximately 120 micrograms/kg/h) of indomethacin within the ventral septal area of the rat brain significantly reduced a centrally induced prostaglandin E1 (PGE1) hyperthermia when compared with infusions of artificial cerebrospinal fluid. A bolus injection of a V1 receptor ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90599-4
更新日期:1989-08-14 00:00:00
abstract::The VIIIth cranial nerve projections in the hagfish, which has only one circular canal in the ear, were studied by transganglionic HRP transport. This nerve has two branches, the nervus utricularis (N. utr.) and the nervus saccularis (N. sac.), each with its own ganglion, the ganglion utriculare (G. utr.) and the gang...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91610-5
更新日期:1985-06-24 00:00:00
abstract::It has been accepted that the descending system from the nucleus locus coeruleus (LC)/nucleus subcoeruleus (SC) plays a significant role in spinal nociceptive processing. The present study was designed to examine modulation of nociceptive processing in the caudal part of the trigeminal sensory nuclear complex, the tri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.023
更新日期:2003-12-12 00:00:00
abstract::The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.016
更新日期:2010-01-15 00:00:00
abstract::Following pulse labeling with [3H]arachidonic acid ([3H]AA), its incorporation pattern in brain reflects regional changes in neurotransmitter signal transduction using phospholipase A2, that is, functional activity. In a rat model of Parkinson's disease, unilateral 6-hydroxydopamine lesion in the substantia nigra, [3H...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00751-3
更新日期:1998-10-05 00:00:00
abstract::Electrophysiological studies on the entopedunculo- and cerebello-thalamic projections were performed by intracellular recordings in the thalamic VA, VL and VM nuclei of cats under sodium pentobarbital anesthesia. Identification of the thalamic neurons were performed electrophysiologically by antidromic activation on s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91091-6
更新日期:1984-06-03 00:00:00
abstract::A pathway from the pretectal region to the dorsal division of the lateral geniculate body has been studied by autoradiography in adult cats following injection of tritium-labeled amino acids into the meso-diencephalic border zone. The findings suggest that the pretecto-geniculate connection arises in the ipsilateral n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90861-6
更新日期:1980-08-11 00:00:00
abstract::The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.10.058
更新日期:2007-01-12 00:00:00
abstract::Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04230-0
更新日期:2003-03-28 00:00:00
abstract::3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death tr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00447-2
更新日期:1997-06-20 00:00:00
abstract:UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90847-4
更新日期:1986-02-05 00:00:00
abstract::Involvement of N-methyl-D-aspartate (NMDA) receptor complex and 5-hydroxytryptamine3 (5-HT3) receptors in state-dependent learning (SDL) induced by ethanol (EtOH) was investigated in the step-through passive avoidance task in rats. Pre-training injections of EtOH or MK-801 reduced step-through latency in the test sess...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01040-8
更新日期:1996-01-15 00:00:00
abstract::Different doses of angiotensin II (AII) or angiotensin III (AIII) microinjections into the zona incerta have been studied on drinking of rats in separate experiments during the consequent 60-min-daily-drinking period. Also, the dipsogen power of only the effective dose of AII and AIII was compared to vehicle treated r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02680-5
更新日期:2003-07-11 00:00:00
abstract::Dipiperidinoethane (DPE) administration produces seizures and CNS lesions. Here we elucidate the cholinergic origin of DPE toxicity. DPE is both an acetylcholinesterase (AChE) inhibitor and a muscarinic antagonist. This dual action negates most of the toxic effects of the compound in vivo. The neurotoxicity is believe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90728-0
更新日期:1985-04-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00860-9
更新日期:1998-11-02 00:00:00
abstract::The cataleptic activity of morphine and methadone was markedly potentiated in frontally decorticated rats with no apparent changes in the onset or duration of action. Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain. The potentiation of methadone-induce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91028-1
更新日期:1988-05-24 00:00:00
abstract::In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90049-x
更新日期:1977-09-09 00:00:00
abstract::Bombesin (BN)- and substance P (SP)-containing neurons are found in the dorsal root ganglia, and project to the dorsal horn of the spinal cord. The present study was undertaken to determine if chronic deafferentation of the cat spinal cord would affect BN or SP receptors in the spinal cord. Ten and 30 days after a uni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90744-9
更新日期:1985-09-23 00:00:00
abstract::Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90346-4
更新日期:1985-01-28 00:00:00
abstract::The respiratory function of cerebral mitochondria harvested from genetically diabetic (BB/W) and streptozotocin-diabetic rats deprived of insulin for 3-4 weeks was found to be unchanged from control values. Furthermore, insulin-deprived BB/W rats subjected to 30 min of insulin-induced hypoglycemic coma demonstrated a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91624-7
更新日期:1989-02-13 00:00:00
abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90163-9
更新日期:1984-04-01 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00