Abstract：
:The relationship between the dorsal raphe neurons projecting to the caudate-putamen and those projecting to the substantia nigra was investigated using a fluorescent retrograde double labeling technique in the rat. The majority of the dorsal raphe neurons projecting to the substantia nigra were found to project also to the caudate-putamen. In addition, a large population of dorsal raphe neurons innervating the caudate-putamen but not the substantia nigra was seen. The cells projecting to the substantia nigra were situated primarily in the dorsal part of the dorsal raphe, whereas those projecting to the caudate-putamen were located throughout the dorsal raphe.
journal_name
Brain Resjournal_title
Brain researchauthors
van der Kooy D,Hattori Tdoi
10.1016/0006-8993(80)90250-4subject
Has Abstractpub_date
1980-03-17 00:00:00pages
1-7issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(80)90250-4journal_volume
186pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The neurotoxicity of ionomycin, a Ca2+ ionophore, was investigated in cultured cortical neurons from embryonic rats. While about 90% of neurons survived 2 h after exposure to ionomycin, the surviving neurons had decreased by about 30 to 40% at 16 h. Both RNA and protein synthesis inhibitors blocked this neurotoxicity....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90317-4
更新日期：1994-07-25 00:00:00
abstract：:The aim of this study was to test the role of the perifornical hypothalamus and adjacent areas in the behavioral and cardiovascular responses to two forms of stress, conditioned fear to context and restraint. Of particular interest was the role of the hypocretin (orexin) containing neurons in these responses. Rats imp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.058
更新日期：2007-01-12 00:00:00
abstract：:During the last few years, recombinant viral vectors derived from adenovirus (Ad), adeno-associated virus (AAV) or lentivirus (LV) have been developed into highly effective vehicles for gene transfer to the adult central nervous system. In recent experiments, in the rat model of Parkinson's disease, all three vector s...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/s0006-8993(00)02915-2
更新日期：2000-12-15 00:00:00
abstract：:The purpose of this paper is to investigate the involvement of various auditory localization mechanisms in the improvement of auditory spatial sensitivity in the case of partial visual deprivation. We compared sensitivity to binaural, monaural, and echo cues between normal-sighted and myopic subjects. In an auditory t...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/j.brainres.2005.01.101
更新日期：2005-04-11 00:00:00
abstract：:To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01121-3
更新日期：1997-01-16 00:00:00
abstract：:The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00396-5
更新日期：1998-07-06 00:00:00
abstract：:Benzodiazepine binding sites are present on gamma-aminobutyric acid (GABA) receptors in hippocampal neurons. Diazepam is known to potentiate the amplitude and prolong the decay of GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs). In this study, benzodiazepine involvement in long-term potentiation (LT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.008
更新日期：2005-11-16 00:00:00
abstract：:In this study, we demonstrate the involvement of left frontoparietal cortices in neural processes for task-switching between skilled movements. Functional magnetic resonance imaging was conducted while thirty-two right-handed healthy participants performed two sequential finger-movement tasks with their left hands. On...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146365
更新日期：2019-11-01 00:00:00
abstract：:It has been proposed that disruption of cholinergic input to the hippocampus and cortex contributes to the learning and memory deficits associated with aging. The data reviewed here, however, suggest that the oft-stated generalization that normal aging is characterized by disruption of cholinergic input to the hippoca...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(87)90007-5
更新日期：1987-11-01 00:00:00
abstract：:Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop hypertension and stroke at earlier ages than do nonmalignant SHRSP. Our previous findings suggested that reactive oxygen species were involved in the development of stroke in this strain. Nitric oxide (NO) which is more released at ischemia, migh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02975-x
更新日期：2002-09-13 00:00:00
abstract：:The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90337-9
更新日期：1986-05-14 00:00:00
abstract：:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines woul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90454-4
更新日期：1991-01-11 00:00:00
abstract：:In this study, we have identified and characterized 5-HT3-like receptors in the rat medial prefrontal cortex (mPFc), an area with a moderate density of 5-HT3 binding sites, using the techniques of single unit recording and microiontophoresis. The microiontophoresis of the 5-HT3 receptor agonist 2-methylserotonin (2-Me...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91316-s
更新日期：1991-06-07 00:00:00
abstract：:Stroke is the third leading cause of death in the US, with a prevalence of 750,000 patients per year, and a social cost estimated at $50 billion. Current therapeutics are targeted at restoring blood flow rather than on preventing the actual mechanisms associated with neuronal cell death. Here, we show that, following ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02922-0
更新日期：2002-08-30 00:00:00
abstract：:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02777-x
更新日期：2003-07-11 00:00:00
abstract：:We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.113
更新日期：2006-04-12 00:00:00
abstract：:Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90567-x
更新日期：1983-08-08 00:00:00
abstract：:Extracellular recordings were conducted in the paraflocculus of anesthetized Long-Evans pigmented rats to determine how ionotophoresis of norepinephrine (NE) affects the responsiveness of individual Purkinje cells and interneurons to presentations of visual stimuli within their visual receptive fields. Presentations o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91421-c
更新日期：1990-04-30 00:00:00
abstract：:Prolidase deficiency is characterized by chronic ulcerative dermatitis, mental retardation, and frequent infections. In the present study we examined the characteristics of rat brain prolidase isoenzymes. Prolidase isoenzymes (PD I and PD II) were isolated from the rat brain using DEAE cellulose column chromatography....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.081
更新日期：2009-12-15 00:00:00
abstract：:Opioid modulation of ingestion includes general opioid antagonism of deprivation-induced water intake and intake of sucrose and saccharin solutions. Previous studies using selective subtype antagonists indicated that opioid effects upon deprivation-induced water intake occurred through the mu2 receptor and that opioid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91274-v
更新日期：1993-08-06 00:00:00
abstract：:Granule cell progenitors in the dentate gyrus of the hippocampal formation have the unusual capacity to be able to divide in the brains of adult rats and primates. The basal proliferation rate of granule cell progenitors in the adult rat is low compared with development, however, it is possible that this rate may beco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00030-4
更新日期：1998-04-20 00:00:00
abstract：:We analyzed flotillin-1 expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis (EAE). Western blot analysis showed that flotillin-1 expression increased significantly in the spinal cords from rats at the peak stage of EAE compared with the levels in control animals (p<0.05) and dec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.054
更新日期：2006-10-09 00:00:00
abstract：:Human soleus H reflexes are attenuated during passive pedalling movements. This depression occurs within 70 ms of movement onset. We hypothesized that the reflex gain would return to control values with a similar brevity following movement. However, H reflexes sampled following a slow (10 rpm) passive pedalling moveme...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/0006-8993(95)00126-b
更新日期：1995-04-17 00:00:00
abstract：:The formation of reactive oxygen species (ROS) has been suggested to be associated with excitotoxicity but the involvement of cytoplasmic enzymes in ROS formation is not clearly known. In the present study, we examined the role of xanthine oxidase (XO), nitric oxide synthase (NOS) and phospholipase A(2) (PLA(2)) in gl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.013
更新日期：2005-03-10 00:00:00
abstract：:Whole cell and perforated patch clamp experiments were conducted on cultured cortical rat neurones (7-21 days in vitro) in order to determine the effects of the anticonvulsant and glutamate release inhibitor Lamotrigine (10-100 microM), on CNS receptors and ion channels. The compound inhibited, indiscriminately, both ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91660-k
更新日期：1993-05-28 00:00:00
abstract：:Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00822-8
更新日期：1995-10-02 00:00:00
abstract：:The contribution of motor and intralaminar thalamic nuclei to the changes of [3H]GABA release evoked in both caudate nuclei (CN) and both substantia nigra (SN) by a unilateral nigral application of muscimol (10(-6) M) was investigated on halothane-anaesthetized cats. Acute lesions were performed on one side of the tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91206-x
更新日期：1984-06-15 00:00:00
abstract：:Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91583-z
更新日期：1992-08-21 00:00:00
abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90800-o
更新日期：1992-03-06 00:00:00
abstract：:Theory of Mind (ToM) has been defined as our ability to predict behaviors of others in terms of their underlying intentions. While the developmental trajectory of ToM had been thought to be invariant across cultures, several ToM studies conducted outside the Anglo-American cultural or linguistic milieus have obtained ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.022
更新日期：2007-08-20 00:00:00
