Abstract：
:We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the kittens receiving 6-OHDA throughout the deprivation period; that is, these kittens were the least affected by MD. 6-OHDA caused a smaller decrease in plasticity in kittens receiving 6-OHDA just prior to eyelid suture and a still smaller decrease in kittens waiting a week between 6-OHDA treatment and eyelid suture. The kittens in all groups receiving 6-OHDA were equally depleted of norepinephrine (NE). We conclude that 6-OHDA decreases plasticity in the visual cortex; however, the time course of this decrease is better related to the time course of the 6-OHDA treatment than to the time course of NE depletion.
journal_name
Brain Resjournal_title
Brain researchauthors
Allen EE,Blakemore LJ,Trombley PQ,Gordon Bdoi
10.1016/0165-3806(87)90137-4subject
Has Abstractpub_date
1987-03-01 00:00:00pages
53-8issue
1eissn
0006-8993issn
1872-6240journal_volume
429pub_type
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