Amelioration of ischemic spinal cord damage by postischemic treatment with propentofylline (HWA 285).


:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without significant functional recovery of hindlimbs. In contrary, post-treatment with HWA 285 recovered the energy state to pre-ischemic value and also significantly improved functional recovery. These findings suggest that the neuroprotective mechanism of HWA 285 in the spinal cord is not associated with inhibition of glutamate release as supposed to operate in the gerbil brain.


Brain Res


Brain research


Danielisová V,Chavko M




Has Abstract


1992-09-11 00:00:00














  • Retrograde cortical aand axonal changes following lesions of the pyramidal tract.

    abstract::Following lesions of the pyramidal tract in hamsters, retrograde changes were studied in the sensorimotor cortex and in the pyramidal tract axons proximal to the lesion, at survival times ranging from 2 weeks to 14 months. Severe cell shrinkage occurred in layer 5 pyramidal neurons as early as 2 weeks, but there was n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kalil K,Schneider GE

    更新日期:1975-05-16 00:00:00

  • Menstrual cycle phase modulates cognitive control over male but not female stimuli.

    abstract::Evolutionary selection pressures have been one of the factors proposed to underlie sex differences in inhibitory control. Consequently, inhibitory control may vary as a function of the menstrual cycle and may be modulated by the stimuli being processed if these stimuli are related to reproductive success. We used func...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Roberts GM,Newell F,Simões-Franklin C,Garavan H

    更新日期:2008-08-11 00:00:00

  • Effects of monocular enucleation at different stages of development on the uncrossed retinocollicular projection in the opossum.

    abstract::Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Méndez-Otero R,Rocha-Miranda CE,Carvalho-Dias E

    更新日期:1986-06-01 00:00:00

  • Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.

    abstract::The role of glial cells in nitric oxide production in the cerebellum of conscious rats was investigated with a glial selective metabolic inhibitor, fluorocitrate. The levels of nitric oxide metabolites (nitrite plus nitrate) in the dialysate following in vivo microdialysis progressively increased to more than 2-fold t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamada K,Senzaki K,Komori Y,Nikai T,Sugihara H,Nabeshima T

    更新日期:1997-07-11 00:00:00

  • Post-hypoxic myoclonus induces Fos expression in the reticular thalamic nucleus and neurons in the brainstem.

    abstract::Post-hypoxic myoclonus is a movement disorder characterized by brief, sudden involuntary muscle jerks. Although the mechanism underlying this disorder remains unclear, earlier pharmacological studies indicated that aberrant activity of specific neuronal circuitry in the central nervous system causes this disorder. In ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tai KK,Truong DD

    更新日期:2005-10-19 00:00:00

  • Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils.

    abstract::The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the develop...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Grund T,Teuchert-Noodt G,Busche A,Neddens J,Brummelte S,Moll GH,Dawirs RR

    更新日期:2007-10-24 00:00:00

  • Neural cograft stimulates the survival and differentiation of embryonic stem cells in the adult mammalian auditory system.

    abstract::Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hu Z,Andäng M,Ni D,Ulfendahl M

    更新日期:2005-07-27 00:00:00

  • Frequent minty chewing gum use is associated with increased trigeminal sensitivity: An fMRI study.

    abstract::Repeated sensory exposure through frequent consumption of certain foods leads to changes in the processing of sensory cues. We investigated the influence of frequent minty chewing gum consumption on the neurobehavioral processing of intranasal trigeminal and olfactory stimuli. fMRI responses to a trigeminal minty odor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Han P,Penzler M,Jonathan W,Hummel T

    更新日期:2020-03-01 00:00:00

  • Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment.

    abstract::Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the main histopathological characteristic of Parkinson's disease. We studied the electrophysiological characteristics of the spontaneous activity of substantia nigra pars compacta dopaminergic neurons in rats with a partial, unil...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bilbao G,Ruiz-Ortega JA,Miguens N,Ulibarri I,Linazasoro G,Gómez-Urquijo S,Garibi J,Ugedo L

    更新日期:2006-04-21 00:00:00

  • Evidence for differential storage of calcitonin gene-related peptide, substance P and serotonin in synaptosomal vesicles of rat spinal cord.

    abstract::Homogenates of rat ventral and dorsal spinal cords were subjected to differential and gradient centrifugation on linear sucrose gradients following lysis of a synaptosomal fraction. The distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) in dorsal spinal cord as well as the distribution of sero...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fried G,Franck J,Brodin E,Born W,Fischer JA,Hiort W,Hökfelt T

    更新日期:1989-10-16 00:00:00

  • Insulin inhibits pyramidal neurons in hippocampal slices.

    abstract::Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Palovcik RA,Phillips MI,Kappy MS,Raizada MK

    更新日期:1984-08-20 00:00:00

  • Modulation of salt appetite by lateral ventricular infusions of angiotensin II and carbachol during sodium depletion.

    abstract::Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fitts DA,Thunhorst RL,Simpson JB

    更新日期:1985-11-04 00:00:00

  • Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system.

    abstract::Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pinnock RD,Lummis SC,Chiappinelli VA,Sattelle DB

    更新日期:1988-08-16 00:00:00

  • Intrathecal treatment with dextrorphan or ketamine potently reduces pain-related behaviors in a rat model of peripheral mononeuropathy.

    abstract::The therapeutic effects of dextrorphan and ketamine, two non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, on neuropathic pain-related behaviors were examined in rats with peripheral mononeuropathy induced by loose ligation of the common sciatic nerve (chronic constrictive injury, CCI). Four daily intr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mao J,Price DD,Hayes RL,Lu J,Mayer DJ,Frenk H

    更新日期:1993-03-05 00:00:00

  • Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease.

    abstract::Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brion JP,Couck AM,Bruce M,Anderton B,Flament-Durand J

    更新日期:1991-01-18 00:00:00

  • Long-term changes in motor cortical organisation after recovery from subcortical stroke.

    abstract::The present study has investigated the long-term changes in the organisation of the corticomotor projection to the hand in a group of subjects who had sustained a subcortical hemispheric stroke up to 15 years previously and had subsequently recovered normal or near-normal motor function. Transcranial magnetic cortical...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章


    authors: Byrnes ML,Thickbroom GW,Phillips BA,Mastaglia FL

    更新日期:2001-01-19 00:00:00

  • Phase-shifting effect of triazolam on the hamster's circadian rhythm of activity is not mediated by a change in body temperature.

    abstract::Treatment with the short-acting benzodiazepine, triazolam (Tz), 6 h before activity onset (CT 6) induces large phase advances in the circadian rhythm of locomotor activity in golden hamsters free-running in constant lighting conditions. These phase shifts are associated with acute increases in locomotor activity. The ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wickland C,Turek FW

    更新日期:1991-09-27 00:00:00

  • Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress.

    abstract::The release of amino acids in the locus coeruleus (LC) of conscious, freely moving rats was studied in time periods of 3 min by use of push-pull superfusion under basal conditions and during application of various experimental stimuli known to influence the activity of the LC-noradrenergic system. Tail pinch for 3 min...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Singewald N,Zhou GY,Schneider C

    更新日期:1995-12-15 00:00:00

  • A role for the parafascicular thalamic nucleus in the development of morphine dependence and withdrawal.

    abstract::The parafascicular thalamic nucleus (nPf) is a critical relay in the ascending system that mediates motor control in the central nervous system (CNS). Yet, little is known about whether or not the nPf is involved in the development of morphine dependence and withdrawal. In the present study, kainic acid was used to ch...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Xiao H,Zhai DX,Yan BB,Wang JH,Xu WS,Wang GY,Bai SS,Kong QF,Sun B,Wang DD,Jin DJ,Li HL

    更新日期:2009-05-19 00:00:00

  • Alteration of conditioned emotional response and conditioned taste aversion after neonatal ventral hippocampus lesions in rats.

    abstract::Sprague-Dawley rats were submitted to bilateral ventral hippocampus lesions 7 days after birth according to the Lipska and Weinberger's procedure for modeling schizophrenia. The aim of the present work was to better characterize their learning capacity. A double latent inhibition study was conducted using respectively...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Angst MJ,Macedo CE,Guiberteau T,Sandner G

    更新日期:2007-04-27 00:00:00

  • Corticotropin-releasing hormone heterogeneous nuclear RNA (hnRNA) and immunoreactivity are induced in extrahypothalamic brain sites by kainic-acid-induced seizures and are modulated by estrogen.

    abstract::Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are pivotal mediators of the hormonal response to stressors and are found within neurons of the paraventricular nucleus of the hypothalamus (PVN) and several extrahypothalamic sites where expression is activity-dependent. Previous work has shown incr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Foradori CD,Lund TD,Nagahara AH,Koenig JI,Handa RJ

    更新日期:2007-08-20 00:00:00

  • Neuroprotective properties of selective estrogen receptor agonists in cultured neurons.

    abstract::To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cordey M,Pike CJ

    更新日期:2005-05-31 00:00:00

  • Glutamate selectively increases the high-threshold Ca2+ channel current in sensory and hippocampal neurons.

    abstract::Previous studies resulted in conflicting conclusions that glutamate application either decreases or increases the activity of Ca2+ channels in hippocampal neurons. We studied whole-cell Ca2+ currents (ICa) in chick dorsal root ganglion neurons and rat hippocampal cells. For both cell types glutamate (1-30 microM) incr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mironov SL,Lux HD

    更新日期:1992-05-15 00:00:00

  • Comparison between red nucleus and precentral neurons during learned movements in the monkey.

    abstract::Monkeys were trained to depress a hold key for a period of 2 sec. After this hold period, either a red or a green cue lamp appeared in random sequence. The red lamp required the monkey to move his hand from the hold key to a target button within 1 sec of the cue presentation. The green lamp required continued depressi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Otero JB

    更新日期:1976-01-09 00:00:00

  • Changes in neuropeptide Y immunoreactivity in the arcuate nucleus during and after food restriction in lactating rats.

    abstract::Previous studies have demonstrated that food restriction during lactation extends the length of lactational infertility in rats. In order to determine whether Neuropeptide Y (NPY) plays a role in the increased length of lactational infertility seen in food-restricted rats, NPY immunoreactivity in the arcuate nucleus o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Abizaid A,Walker CD,Woodside B

    更新日期:1997-07-04 00:00:00

  • Heat shock protein 72 restores cyclic AMP accumulation after heat shock in N18TG2 cells.

    abstract::Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki S

    更新日期:1998-04-20 00:00:00

  • PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

    abstract::Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through modulation of neurotransmission at GABA(A) receptors containing alpha1, alpha2, alpha3 or alpha5 subunits, and may have numerous experimental and clinical applications. The ability of non-sele...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Savić MM,Clayton T,Furtmüller R,Gavrilović I,Samardzić J,Savić S,Huck S,Sieghart W,Cook JM

    更新日期:2008-05-07 00:00:00

  • Contrasting features of ERK1/2 activity and synapsin I phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo.

    abstract::Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamagata Y,Nairn AC

    更新日期:2015-11-02 00:00:00

  • Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord.

    abstract::The presence of corticotropin releasing factor (CRF)-immunoreactive nerve fibers and cell bodies in the spinal cord is demonstrated. Immunopositive fibers were found in the lateral column of the white matter, in laminae I, V-VII, X, and in the intermediolateral column of the spinal cord. Complete transection of the sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Merchenthaler I,Hynes MA,Vigh S,Shally AV,Petrusz P

    更新日期:1983-09-26 00:00:00

  • Spatiotemporal patterns of the astroglial proliferation in rat brain injured at the postmitotic stage of postnatal development: a combined immunocytochemical and autoradiographic study.

    abstract::Proliferative response of astrocytes to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats using a combination of [3H]thymidine autoradiography and immunocytochemical staining for glial fibrillary acidic protein. At different intervals following injury the animals were injected with [3H]t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Janeczko K

    更新日期:1989-04-24 00:00:00