Amelioration of ischemic spinal cord damage by postischemic treatment with propentofylline (HWA 285).

Abstract:

:The effect of the xanthine derivative propentofylline (HWA 285) on metabolic and functional recovery in rabbit spinal cord after 20 and 30 min ischemia and 4 days of reperfusion was investigated. Pre-treatment with 20 mg/kg significantly improved recovery of the energy state in the spinal cord, however, without significant functional recovery of hindlimbs. In contrary, post-treatment with HWA 285 recovered the energy state to pre-ischemic value and also significantly improved functional recovery. These findings suggest that the neuroprotective mechanism of HWA 285 in the spinal cord is not associated with inhibition of glutamate release as supposed to operate in the gerbil brain.

journal_name

Brain Res

journal_title

Brain research

authors

Danielisová V,Chavko M

doi

10.1016/0006-8993(92)91114-t

subject

Has Abstract

pub_date

1992-09-11 00:00:00

pages

321-4

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(92)91114-T

journal_volume

590

pub_type

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