Abstract：
:In vivo release of labeled serotonin ([3H]5-HT) from the parietal cortex was investigated by cortical cup technique and electrical stimulation of midbrain raphe in rats anesthetized with pentobarbital sodium. The spontaneous efflux of tritium from the parietal cortex preload with [3H]5-HT followed a multiphasic exponential course. After 120 min, the rate of efflux appeared to fit the single exponential function (slow phase). Imipramine (10(-6)-10(-3) M) produced a dose-dependent increase in the spontaneous release. When pargyline in concentrations ranging from 10(-4) to 10(-3) M were added to the medium in the cup, the unchanged [3H]5-HT significantly increased in a dose-dependent manner and the slow declining coefficient of tritium efflux significantly decreased in the presence of 10(-4) pargyline. Stimulation of the rostral two-thirds of the dorsal raphe and the lateral 5-HT bundle originating from the dorsal raphe significantly increased the release of [3H]5-HT and its metabolites while stimulation of the caudal one-third of the dorsal raphe did not produce a significant increase in the release of [3H]5-HT and its metabolites. Stimulation of the medium raphe produced no or only a slight increase in the release of [3H]5-HT and its metabolites. These findings are a direct demonstration of the in vivo release of [3H]5-HT from the parietal cortex with stimulation of the dorsal raphe, particularly the rostral two-thirds of the nucleus and provide the neurochemical evidence for the dorsal raphe-cortical 5-HT pathway via the lateral 5-HT bundle.
journal_name
Brain Resjournal_title
Brain researchauthors
Fujiwara H,Uemoto M,Tanaka Cdoi
10.1016/0006-8993(81)90137-2subject
Has Abstractpub_date
1981-07-20 00:00:00pages
351-60issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90137-2journal_volume
216pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Glioblastoma is the most common primary brain tumor in adults from which about 15,000 patients die each year in the United States. Despite aggressive surgery, radiotherapy and chemotherapy, median survival remains only 1 year. Here we evaluate growth of primary human brain tumor cells in a defined nutrient culture med...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.064
更新日期：2007-07-09 00:00:00
abstract：:To investigate whether differences in vulnerability to free radicals might underlie differences among striatal neurons in their vulnerability to neurodegenerative processes such as occur in ischemia and Huntington's disease, we have analyzed the localization of superoxide free radical scavengers in different striatal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01320-2
更新日期：1996-02-05 00:00:00
abstract：:The levels of N-acetyl-aspartate (NAA) and N-acetyl-aspartyl-glutamate (NAAG) were measured in several regions and in whole brain of rats from 15 days of gestation (DG) to adulthood by means of an isocratic HPLC method. The levels of NAAG in whole brain increased 3-fold between 15 DG and birth, which was 90% of the ad...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90150-0
更新日期：1984-07-01 00:00:00
abstract：:Vestibular nerve branches innervating the sensory epithelia of the three semicircular canals or of the three otolith organs of frogs were selectively labeled in-vitro with biocytin. Labeled afferent fibers from the semicircular canals, utricle, and lagena were encountered in each of the four vestibular nuclei and thei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03075-x
更新日期：2001-12-07 00:00:00
abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.07.028
更新日期：2015-10-22 00:00:00
abstract：:Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90774-x
更新日期：1980-11-10 00:00:00
abstract：:The suitability of (3H)DPCPX (8-cyclopentyl-1,3-dipropylxanthine), a xanthine derivative, as an vivo probe for labelling adenosine A1 receptors was studied in rats. [3H]DPCPX (nM) penetrated largely into the brain (0.8% of the injected dose per gram of brain tissue 5 min after injection). Brain concentrations stayed a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90845-z
更新日期：1992-12-18 00:00:00
abstract：:Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90649-1
更新日期：1976-03-05 00:00:00
abstract：:The distribution of substance P receptors was examined by autoradiography at all levels of the human postmortem spinal cord using the ligand [125I]Bolton-Hunter substance P. Adjacent sections were used to localize substance P-like immunoreactivity by a radioimmunohistochemical technique. In the control spinal cord sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90032-2
更新日期：1989-03-27 00:00:00
abstract：:Recently the nuclear proto-oncogene c-fos has been shown to be rapidly and transiently expressed following seizures in many types of epilepsies. Until now, immunohistochemical as well as in situ hybridization studies have reported that the dentate gyrus of the hippocampus and most of the cortical areas were invariably...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90988-n
更新日期：1990-06-04 00:00:00
abstract：:In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03043-2
更新日期：2001-01-05 00:00:00
abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90594-y
更新日期：1992-01-20 00:00:00
abstract：:A push-pull cannula supplied with artificial CSF was implanted in the striatum of anaesthetized rats, and the basal extracellular DA and DOPAC was assayed in the superfusates using HPLC and electrochemical detection. Simultaneously, a carbon fibre electrode was implanted in close proximity of the cannula and the evoke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00706-v
更新日期：1995-10-09 00:00:00
abstract：:The origin of descending pathways to thoracic and cervical levels of the spinal cord has been investigated with retrograde tracing techniques in a series of pouch young and adult opossums. The opossum was chosen because it is born in a very immature state, 12-13 days after conception, and has a protracted development ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90102-0
更新日期：1984-08-01 00:00:00
abstract：:The enzymatic and regulatory properties of Ca2+/calmodulin-dependent protein kinase in the postsynaptic density (mPSDp CaM kinase) of the rat forebrain was compared with those of soluble Ca2+/calmodulin-dependent protein kinase II (CaM kinase II). mPSDp CaM kinase was different from soluble CaM kinase II in terms of s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91222-e
更新日期：1993-04-30 00:00:00
abstract：:Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90092-x
更新日期：1980-05-12 00:00:00
abstract：:Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was anta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91166-p
更新日期：1993-12-31 00:00:00
abstract：:The effects of various nucleotides on the fast tetrodotoxin-sensitive (f-TTX-S) and the slow tetrodotoxin-resistant (s-TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were investigated using the patch-clamp technique. Nucleoside triphosphates (NTPs; ATP, GTP, UTP and CTP) and nucleoside diphosphates (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.061
更新日期：2004-05-01 00:00:00
abstract：:The locus coeruleus of the adult albino rat is a clearly delimited nucleus in Nissl-stained preparations. It is surrounded by an extensive, relatively neuron-free neuropil which is not stained in reduced silver and Luxol fast blue preparations. Most if not all locus coeruleus neurons contain the enzyme dopamine-beta-h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90207-9
更新日期：1976-06-25 00:00:00
abstract：:The spiral ganglion accommodates the cell bodies of the acoustic nerve fibres connecting the hair cells to the central nervous system. As the ionic channels containing various voltage-gated K+ channel (Kv) subunits play pivotal roles in determining the functional properties and firing behaviour of the spiral ganglion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.072
更新日期：2008-05-19 00:00:00
abstract：:Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01086-5
更新日期：1998-12-14 00:00:00
abstract：:Dendritic spines are actin-rich protrusions from the dendritic shaft, considered to be the locus where most synapses occur, as they receive the vast majority of excitatory connections in the central nervous system (CNS). Interestingly, hippocampal spines are plastic structures that contain a dense array of molecules i...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.05.024
更新日期：2014-07-21 00:00:00
abstract：:In this study, the effects of chronic morphine administration (20-30 days) on long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices. Orthodromic population spike (OPS) amplitude and delay (peak latency) were measured as indices of increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01148-2
更新日期：1999-01-09 00:00:00
abstract：:Following transection of a peripheral nerve in mice, a newly synthesized neurotropic pyrimidine compound, MS-818 was administered intraperitoneally at a dose of 1 mg kg-1 b.wt. day-1. The film model experiments for analyzing the early growth of axonal regeneration suggested that MS-818 activated Schwann cells which mi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01491-1
更新日期：1998-03-23 00:00:00
abstract：:Cytosol androgen receptors were assayed in guinea pig brain and pituitary tissues, using [3H]R1881 as ligand. These receptors had an apparent Kd of 0.04 nM and were androgen-specific (R1881 greater than dihydrotestosterone greater than testosterone = estradiol greater than progesterone). Concentrations of cytosol andr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90158-2
更新日期：1987-06-09 00:00:00
abstract：:Awake, intact monkeys were trained to perform discrete flexion or extension movements of the hand about the wrist in response to visual signals. The object of the movement was to align a cursor, coupled to a manipulandum, on a target line. Cursor and target lines are displayed on a video monitor placed in front of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90726-0
更新日期：1982-03-25 00:00:00
abstract：:The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91070-x
更新日期：1986-10-22 00:00:00
abstract：:This EEG study (N=33) examined event-related potentials associated with conflict between activated responses in the Stroop task, in order to examine the conflict monitoring theory of cognitive control, which predicts the strength of exerted control to be proportional to the detected level of conflict. However, existin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.08.041
更新日期：2016-11-01 00:00:00
abstract：:Analgesia can be elicited following microinjections of morphine, mu-selective agonists and beta-endorphin into the amygdala. These analgesic responses are mediated by opioid synapses in the periaqueductal gray (PAG) since general (naltrexone), mu (beta-funaltrexamine) and delta2 (naltrindole isothiocyanate) opioid ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01115-3
更新日期：1998-01-01 00:00:00
abstract：:Quantitative autoradiography was used to analyze cholecystokinin receptor (CCK-R) binding in the ventromedial hypothalamic nucleus (VMH) of gonadectomized rats treated with estrogen or testosterone. In the rostral VMH, sex steroids did not affect binding levels. In the caudal VMH, in both gonadectomized male and femal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01561-2
更新日期：1996-03-18 00:00:00
