Calbindin D28k-containing splanchnic and cutaneous dorsal root ganglion neurons of the rat.

abstract：:Glutamate carboxypeptidase II may modulate excitatory neurotransmission through the catabolism of the neuropeptide N-acetylaspartylglutamate (NAAG) and possibly other endogenous peptide substrates. To investigate the molecular properties of cloned human GCP II (hGCP II), we analyzed the NAAG-hydrolytic activity convey...

journal_title：Brain research

authors： Luthi-Carter R,Barczak AK,Speno H,Coyle JT

更新日期：1998-06-08 00:00:00

abstract：:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells,...

journal_title：Brain research

authors： Ishizaki Y,Morita I,Murota S

更新日期：1989-08-07 00:00:00

abstract：:Histone proteins from purified nuclei of neonatal and adult mouse retinas were analyzed and compared utilizing SDS-polyacrylamide gel electrophoresis. Identical procedures were applied to examine the histones extracted from the brains of the same animals. In the newborn and mature retina and brain, 8 histone fractions...

journal_title：Brain research

authors： Perkins PS,Young RW

更新日期：1987-06-01 00:00:00

abstract：:In the present study we found that mesencephalic trigeminal (Mes-V) neurons of the rat are innervated by nitrergic fibers and that nitric oxide (NO) modifies the electrophysiological properties of these cells. Mes-V neurons were surrounded by a network of fibers that contained neuronal nitric oxide synthase (nNOS); th...

journal_title：Brain research

authors： Pose I,Sampogna S,Chase MH,Morales FR

更新日期：2003-01-17 00:00:00

abstract：:The blood-brain barrier consists of the cerebral microvascular endothelium, pericytes, astrocytes, and neurons. In this study, we analyzed the influence of primary porcine brain capillary pericytes on the barrier integrity of primary porcine brain capillary endothelial cells in a species-consistent in vitro coculture ...

journal_title：Brain research

authors： Thanabalasundaram G,Pieper C,Lischper M,Galla HJ

更新日期：2010-08-06 00:00:00

abstract：:Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...

journal_title：Brain research

authors： Sarkar S,Fekete C,Légrádi G,Lechan RM

更新日期：2003-09-26 00:00:00

abstract：:Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...

journal_title：Brain research

authors： Bronstein DM,Perez-Otano I,Sun V,Mullis Sawin SB,Chan J,Wu GC,Hudson PM,Kong LY,Hong JS,McMillian MK

更新日期：1995-12-15 00:00:00

abstract：:The tumor promoting compound 12-O-tetradecanoyl-phorbol-13-acetate (TPA) specifically binds to and activates protein kinase C (PKC). This enzyme is widely distributed in the brain. It plays a pivotal role in transmembrane signalling. Arachidonic acid conversion is a common cellular response to membrane perturbation. W...

journal_title：Brain research

authors： Hartung HP,Toyka KV

更新日期：1987-08-11 00:00:00

abstract：:Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was anta...

journal_title：Brain research

authors： Marshall JF,Cole BN,LaHoste GJ

更新日期：1993-12-31 00:00:00

abstract：:Using a perifusion culture technique, the pattern of vasopressin release from the suprachiasmatic nucleus was studied in vitro under basal and stimulated conditions. Individual rat suprachiasmatic explants released vasopressin in a rhythmic fashion and these rhythms persisted with a circadian period for up to 4 cycles...

journal_title：Brain research

authors： Earnest DJ,Sladek CD

更新日期：1987-10-06 00:00:00

abstract：:Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly un...

journal_title：Brain research

authors： Wen Y,Yang S,Liu R,Simpkins JW

更新日期：2004-10-01 00:00:00

abstract：:Recent studies have demonstrated the neuroprotective properties of the novel imidazoquinoline benzodiazepine receptor partial agonist, PNU-101017, in the gerbil forebrain ischemia model. The compound effectively reduces delayed post-ischemic (5 min bilateral carotid occlusion) hippocampal CA1 neuronal degeneration eve...

journal_title：Brain research

authors： Hall ED,Fleck TJ,Oostveen JA

更新日期：1998-07-06 00:00:00

abstract：:Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...

journal_title：Brain research

authors： Phinney DG,Isakova IA

更新日期：2014-07-21 00:00:00

abstract：:The cloned 5-HT3 receptor from NCB-20 neuroblastoma cells was expressed in Xenopus oocytes. In these oocytes, 5-HT, the selective 5-HT3 receptor agonists, 2-methyl-5-HT and m-chlorophenylbiguanide activated an inward current which was sensitive to the specific 5-HT3 receptor antagonist LY278584. Cocaine (0.1 to 10 mic...

journal_title：Brain research

authors： Fan P,Oz M,Zhang L,Weight FF

更新日期：1995-03-06 00:00:00

abstract：:The effects of the possible metabolites of taurine--taurocyamine and hypotaurine--and of homotaurine on spike discharge frequency of guinea pig cerebellar Purkinje cells were investigated in comparison with taurine and GABA. Taurocyamine, hypotaurine and homotaurine all dose-dependently suppressed the spike frequency ...

journal_title：Brain research

authors： Okamoto K,Sakai Y

更新日期：1981-02-16 00:00:00

abstract：:Seizures kindled with amygdaloid carbachol injections are transynaptic, dependent on activation of a specific population of muscarinic receptors, and some components of their expression could be mediated by intracellular second messengers. We measured cyclic GMP and cyclic AMP concentrations in micropunch biopsies of ...

journal_title：Brain research

authors： Wasterlain CG,Csiszar E,Fairchild MD

更新日期：1986-11-12 00:00:00

abstract：:While genetic predisposition is a major factor, it is not known how development of attention-deficit/hyperactivity disorder (ADHD) is modulated by early life stress. The spontaneously hypertensive rat (SHR) displays the behavioral characteristics of ADHD (poorly sustained attention, impulsivity, hyperactivity) and is ...

journal_title：Brain research

authors： Sterley TL,Howells FM,Russell VA

更新日期：2016-06-15 00:00:00

abstract：:Behavioral stress is likely to contribute to the development of hypertension in susceptible individuals. We reported that hemodynamic response patterns to acute startle vary and that those patterns predict the predisposition of rats to sustained stress-induced elevations in arterial pressure. Since considerable eviden...

journal_title：Brain research

authors： Tan Y,Gan Q,Knuepfer MM

更新日期：2003-04-04 00:00:00

abstract：:In the course of pulse-label studies on the axonal transport of the small, basic, actin-binding proteins--actin depolymerizing factor, cofilin and profilin--in chicken motor neurones, we observed a heavily labelled protein of M(r) 18 kDa and pI 8.2 on fluorographs of two-dimensional polyacrylamide gels. On the basis o...

journal_title：Brain research

authors： Yuan A,Mills RG,Bamburg JR,Bray JJ

更新日期：1997-10-17 00:00:00

abstract：:This cross-sectional study was designed to investigate grey matter changes that occur in healthy aging and the relationship between grey matter characteristics and executive functioning. Thirty-six young adults (18-30 years old) and 43 seniors (60-75 years old) were included. A general executive score was derived from...

journal_title：Brain research

authors： Manard M,Bahri MA,Salmon E,Collette F

更新日期：2016-07-01 00:00:00

abstract：:In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...

journal_title：Brain research

authors： Johnson EW,Eller PM,Jafek BW,Norman AW

更新日期：1992-02-14 00:00:00

abstract：:To determine whether the idiosyncratic distribution of transduction mechanisms for bitter tastants in rat taste receptor cells (TRCs) could be inferred from the neural activity they evoke, single neuron responses to ten bitter-tasting compounds were recorded from rat glossopharyngeal (n = 30) and chorda tympani (n = 2...

journal_title：Brain research

authors： Dahl M,Erickson RP,Simon SA

更新日期：1997-05-09 00:00:00

abstract：:We examined whether manipulations of fat metabolism influence the feeding response to peripheral or central administration of 5-thio-D-glucose (5-TG), a potent inhibitor of glucose utilization. The increase in food intake produced by peritoneal (50 mg/kg) or fourth ventricular (50, 100, 150 micrograms) 5-TG was potent...

journal_title：Brain research

authors： Tordoff MG,Flynn FW,Grill HJ,Friedman MI

更新日期：1988-04-05 00:00:00

abstract：:To gain greater insight on the molecular mechanisms that underlie ischemic stroke, we compared gene expression profiles in transient (tMCAO) and permanent middle cerebral artery occlusion (pMCAO) stroke models using Expression Analysis Systematic Explorer (EASE) pathway analysis software. Many transcripts were induced...

journal_title：Brain research

authors： Ford G,Xu Z,Gates A,Jiang J,Ford BD

更新日期：2006-02-03 00:00:00

abstract：:It is well established that autonomic control of digestive function is modulated by central autonomic neurotransmission. In this context it has been shown that digestive function can be modulated by exogenous neuropeptides microinjected into specific brain sides. Furthermore, there is considerable evidence suggesting ...

journal_title：Brain research

authors： Tebbe JJ,Pasat IR,Mönnikes H,Ritter M,Kobelt P,Schäfer MK

更新日期：2005-03-02 00:00:00

abstract：:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+...

journal_title：Brain research

authors： Hablitz JJ,Heinemann U

更新日期：1987-12-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorr...

journal_title：Brain research

authors： Kim JM,Lee ST,Chu K,Jung KH,Song EC,Kim SJ,Sinn DI,Kim JH,Park DK,Kang KM,Hyung Hong N,Park HK,Won CH,Kim KH,Kim M,Kun Lee S,Roh JK

更新日期：2007-12-05 00:00:00

abstract：:Purkinje cell dendritic arborizations were studied in HRP intracellularly stained mature neurons grown during 30-50 days in organotypic cerebellar cultures from newborn kittens. The effects of afferent fiber depletions on the final dendritic topological parameters were investigated by computer assisted methods. Three ...

journal_title：Brain research

authors： Calvet MC,Calvet J,Camacho R,Eude D

更新日期：1983-12-05 00:00:00

abstract：:The neocortex has proven resistant to LTP induction using standard in vitro and acute, in vivo preparations. Because the neocortex is widely thought to be involved in long-term information storage, this resistance raises questions about the validity of LTP as a memory model. Recently, we have shown that the neocortex ...

journal_title：Brain research

authors： Boyd TE,Trepel C,Racine RJ

更新日期：2000-10-20 00:00:00

abstract：:Corticotropin-releasing factor (CRF) has been hypothesized to be involved in the pathophysiology of anxiety, depression, cognitive and feeding disorders. Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS. However, the role for each receptor subtype in animal models of n...

journal_title：Brain research

authors： Contarino A,Dellu F,Koob GF,Smith GW,Lee KF,Vale W,Gold LH

更新日期：1999-07-17 00:00:00