Abstract:
:The possibility that the opioid delta-receptor mediates antinociception in tests where heat is the noxious stimulus was investigated using highly selective mu- and delta-agonist and -antagonists. Antinociceptive dose-response curves were constructed for mu ([D-Ala2,NMePhe4,Gly-ol]enkephalin, DAGO; morphine) and delta ([D-Pen2,D-Pen5]enkephalin, DPDPE)-agonists in the absence, and in the presence of the mu non-surmountable antagonist, beta-funaltrexamine (beta-FNA) or the delta-antagonist ICI 174,864 (N,N-diallyl-Tyr-Aib-Aib-Phe-Leu-OH, where Aib is alpha-amino-isobutyric acid). Agonists and ICI 174,864 were given alone in the same intracerebroventricular (i.c.v.) or intrathecal (i.th.) injection to mice 20 min prior to testing in the warm-water (55 degrees C) tail-withdrawal test (+10 min for i.th. DPDPE); beta-FNA was given as a single i.c.v. or i.th. pretreatment dose (20 and 0.01 nM, respectively) 4 h prior to testing. I.c.v. pretreatment with beta-FNA resulted in a rightward displacement of the DAGO and morphine antinociceptive dose-response lines, but failed to displace the i.c.v. DPDPE curve. Similarly, i.th. pretreatment with beta-FNA displaced the i.th. morphine dose-response curve to the right without affecting the i.th. DPDPE antinociceptive dose-response line. ICI 174,864 (1 and 3 micrograms) produced a dose-related antagonism of i.c.v. or i.th. DPDPE, but did not alter the antinociceptive effects of DAGO or morphine given by the same routes. Co-administration of ICI 174,864 (3 micrograms) with i.c.v. morphine in beta-FNA pretreated (but not control) mice resulted in a further rightward displacement of the morphine dose-response line.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Heyman JS,Mulvaney SA,Mosberg HI,Porreca Fdoi
10.1016/0006-8993(87)90244-7subject
Has Abstractpub_date
1987-09-08 00:00:00pages
100-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(87)90244-7journal_volume
420pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91597-0
更新日期:1994-08-29 00:00:00
abstract::Studies with radioactive antipyrene and deoxyglucose indicated that both blood flow and metabolism are enhanced in the goldfish optic tectum following a brief visual stimulation. It is concluded that the brain of cold-blooded animals demonstrates regionally regulated physiological alterations, previously reported only...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90195-1
更新日期:1979-01-26 00:00:00
abstract::Horseradish peroxidase (HRP) in slow-release gel was unilaterally implanted in the transected dorsolateral funiculus (DLF) of either cervical, midthoracic, lumbar or sacral spinal cord levels of adult male rats. Cell mappings were made of all brain areas projecting through the DLF. Following cervical implants, dense l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91139-2
更新日期:1981-11-02 00:00:00
abstract::Using an immunocytochemical technique we have analyzed changes in substance P, somatostatin, calcitonin gene-related peptide, and galanin immunoreactivity pattern in the rat dorsal root ganglia. After 7 days of adrenalectomy, sham operated rats were compared with adrenalectomized animals either receiving a daily intra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91893-7
更新日期:1994-03-21 00:00:00
abstract::Neurointermediate lobes of rats comprise elements which, when excited in vitro, bring about an inhibition of the release of melanocyte stimulating hormone (MSH). Superfusion of neurointermediate lobes of intact donor rats with medium containing 45 mM K+ induced a stimulation of the release of oxytocin, arginine-vasopr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91047-3
更新日期:1979-08-10 00:00:00
abstract::The extrafusal and intrafusal muscle fibers in the masseter muscle are innervated by motoneurons in the trigeminal motor nucleus (Mo 5). In the present study, we found that the number of trigeminal motor neurons in the male mouse was significantly larger than that in the female. However, we could not detect any signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90763-d
更新日期:1993-11-05 00:00:00
abstract::A polyclonal antiserum raised against the carboxy-terminal 17 amino acids of the rat p185c-neu (anct) reacted with a 140 kDa polypeptide in membranes of synaptosome fractions from neocortex and hippocampus of 11-day-old and adult rats. The same antiserum reacted with a 185 kDa polypeptide in microsome membranes from r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00981-u
更新日期:1995-11-27 00:00:00
abstract::Transcranial magnetic stimulation (TMS) of human lower limb motor cortex paired with common peroneal nerve electrical stimulation produces a lasting modulation of motor cortex excitability following the principles of spike-timing-dependent plasticity. We previously demonstrated that this "paired associative stimulatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.062
更新日期:2007-06-11 00:00:00
abstract::Previous work, using membrane receptor binding techniques, demonstrated an increase in hippocampal MK-801 binding sites in mice after chronic ethanol ingestion. The current studies, using quantitative autoradiography, demonstrate that chronic ethanol ingestion also produces increases in MK-801 binding in cerebral cort...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1991-04-26 00:00:00
abstract::In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00649-0
更新日期:1998-09-14 00:00:00
abstract::The current study assessed the influence of excitotoxic lesions of the insular cortex (IC) on taste-potentiated odor aversion (TPOA) learning. Water-deprived rats initially received a single odor-toxicosis or odor/taste-toxicosis pairing and were subsequently tested, in separate trials, with the odor and the taste sti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.051
更新日期:2009-11-10 00:00:00
abstract::Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90328-4
更新日期:1989-10-23 00:00:00
abstract::The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91622-8
更新日期:1991-01-25 00:00:00
abstract::The thalamic paraventricular nucleus (PVT) receives afferents from numerous brain areas, including the hypothalamic suprachiasmatic nucleus (SCN), considered to be the major circadian pacemaker. The PVT also sends projections to the SCN, limbic system centers and some nuclei involved in the control of the Sleep-Wake c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.09.017
更新日期:2008-11-19 00:00:00
abstract::Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program tissue specific patterns of gene expression. Cells, including neurons, undergo massive epigenetic reprogramming during development through modifications to chromatin structure, and by covalent modifications of the DNA through methyla...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2008.07.074
更新日期:2008-10-27 00:00:00
abstract::Tyrosine hydroxylase (TH) in freshly prepared 45,000 g supernatant from rat striatum was fractionated by DEAE-cellulose chromatography. The elution was made with 2 vols. of buffer (50 mM Tris, pH 7.4; 2 mM dithiothreitol) followed by 4 vols. of a linear NaCl gradient (0 0.3 M) in the same buffer. TH activity was elute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90397-9
更新日期:1983-05-23 00:00:00
abstract::Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90172-6
更新日期:1985-07-15 00:00:00
abstract::Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in cerebro-cortical neurons exposed to hypoxia (3 days in 1% of O2) or normoxia (room air). Hypoxia led to increased a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.074
更新日期:2008-09-10 00:00:00
abstract::Previous studies showed the role of basolateral amygdala (BLA) in cannabinoid-induced antinociception. Furthermore, the nucleus accumbens (NAc) plays an important role in mediating the suppression of pain in animal models. The present study extended the role of dopamine receptors within the NAc in antinociceptive effe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.06.023
更新日期:2012-08-30 00:00:00
abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00908-6
更新日期:1997-10-10 00:00:00
abstract::Morphologically distinct subsets of mesotelencephalic neurons were sought following retrograde transport of Fluoro-Gold from iontophoretic injections relatively restricted to the medial shell, core or rostral pole subterritories of the nucleus accumbens. The diameter and lengths of Fluoro-Gold immunolabeled dendrites ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00556-6
更新日期:1995-08-14 00:00:00
abstract::Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90010-8
更新日期:1988-06-14 00:00:00
abstract::The effect of a single train of electrical hippocampal stimulation on ACTH and corticosterone (CS) responses to subsequent photic stimulation was studied in freely moving male rats. The hippocampal stimulation inhibited the stress-induced rise [corrected] in serum CS levels up to 150 h when compared to sham stimulated...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02538-0
更新日期:2001-08-17 00:00:00
abstract::Projections to the rostral ventrolateral medulla (RVLM) and nucleus raphe magnus (NRM) appear to originate from neurones with overlapping distributions in the periaqueductal grey (PAG) as demonstrated by the retrograde transport of red and green fluorescent latex microspheres. Furthermore, double-labelling studies dem...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00784-6
更新日期:1996-09-09 00:00:00
abstract::Brain cortico-striatal circuits have consistently been implicated in the pathology of addiction related disorders. We applied a reliable seed-based analysis of the resting-state brain activity to comprehensively delineate the subdivisions of striatal functional connectivity implicated in internet gaming disorder. Amon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.12.042
更新日期:2015-03-30 00:00:00
abstract::Protein kinase C (PKC) activity was measured in rat brain with 2 h of middle cerebral artery (MCA) and common carotid artery (CCA) occlusion, using dual autoradiography of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu). In the ischemic brain, it required more than 120 min of incubation to obtain a p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01342-x
更新日期:1997-03-07 00:00:00
abstract::The presence of thyrotropin-releasing-hormone-immunoreactive (TRH-ir) amacrine cells in the retina of amphibians is reported for the first time. The anuran and urodele retinas studied exhibit major differences in the distribution of TRH-ir cells. In the two urodele species investigated, most TRH-ir amacrine cells were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03307-8
更新日期:2002-02-01 00:00:00
abstract::Neurons and glial cells can be stained by Lucifer Yellow CH in vitro to produce a Golgi-like fluorescent or electron-dense stain. This technique has been applied successfully in the retinas of several species, rat brain slices and embryonic chick spinal cord. The relative proportion of stained neurons residing in diff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90027-2
更新日期:1986-09-24 00:00:00
abstract::Unilateral destruction of the entorhinal area in the rat results in the proliferation of a pathway from the surviving contralateral entorhinal area to the fascia dentata denervated by the lesions (the crossed temporodentate pathway). The present study analyzes the point of entry of these reinnervating fibers into the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90464-3
更新日期:1980-02-10 00:00:00
abstract::p-Chlorophenylalanine was administered to rats to inhibit hepatic phenylalanine hydroxylase activity. Two days later, phenylalanine injection was noted to produce substantial increases in serum phenylalanine levels, and relatively modest increments in serum tyrosine levels. Rats injected with p-chlorophenylalanine 2 d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90777-4
更新日期:1989-10-16 00:00:00