Abstract:
:Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothesized that continuous administration of BDNF at low dose might be more effective for epilepsy model of animals because high dose of BDNF was used in many studies. BDNF-secreting cells were genetically made and encapsulated for transplantation. Rats receiving BDNF capsule showed significant amelioration of seizure stage and reduction of the number of abnormal spikes at 7 days after kainic acid administration, compared to those of control group. The number of BrdU and BrdU/doublecortin positive cells in the hippocampus of BDNF group significantly increased, compared to that of control group. NeuN positive cells in the CA1 and CA3 of BDNF group were significantly preserved, compared to control group. In conclusion, low dose administration using encapsulated BDNF-secreting cells exerted neuroprotective effects with enhanced neurogenesis on epilepsy model of rats. These results might suggest the importance of the dose and administrative way of this neurotrophic factor to the epilepsy model of animals.
journal_name
Brain Resjournal_title
Brain researchauthors
Kuramoto S,Yasuhara T,Agari T,Kondo A,Jing M,Kikuchi Y,Shinko A,Wakamori T,Kameda M,Wang F,Kin K,Edahiro S,Miyoshi Y,Date Idoi
10.1016/j.brainres.2010.10.054subject
Has Abstractpub_date
2011-01-12 00:00:00pages
281-9eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02323-1journal_volume
1368pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Axotomy of cholinergic neurons in the medial septum-diagonal band and degeneration of their terminals in the hippocampus resulting from fornix-fimbria lesions induce elevation of NGF content in these two brain regions. Postlesion levels of cholinergic neuron-specific ChAT activity in the septum suggest that endogenous...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90198-8
更新日期:1986-06-25 00:00:00
abstract::The relationship between seizure propensity and the vascular anatomy of the anterior cerebral arteries, or stroke induced by unilateral ligation of the common carotid artery, was investigated utilizing well differentiated colonies of seizure-prone (SP) and non-seizure-prone (NSP) gerbils. Twenty SP and 20 NSP gerbils ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90867-8
更新日期:1982-02-25 00:00:00
abstract::Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91012-h
更新日期:1993-06-18 00:00:00
abstract::Dual-labeling immunohistochemical or in situ hybridization studies for the recently cloned epsilon-subunit and several neuropeptides were performed in the rat hypothalamus. We revealed an extensive co-expression (>90%) with hypocretin (Hcrt), oxytocin (OT), the gonadotropin-releasing hormone (GnRH), and the melanin-co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04270-1
更新日期:2003-03-28 00:00:00
abstract::Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.02.011
更新日期:2014-03-27 00:00:00
abstract::The mismatch negativity (MMN) event-related potential is elicited by changes in repetitive auditory stimuli. The present paper suggests that: (1) an acoustic model of the auditory environment is maintained even in the absence of attention focussed on auditory stimuli, preattentively detecting repetitive features of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01008-6
更新日期:1996-12-02 00:00:00
abstract::Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90089-5
更新日期:1981-04-27 00:00:00
abstract::Cell bodies and dendrites of neurones in the thalamic reticular nucleus projecting to the dorsal lateral geniculate nucleus in adult albino rats, were labelled by retrograde transport of horseradish peroxidase (HRP). In the same animals the terminals of cortico-reticular axons were made identifiable by ipsilateral vis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90685-5
更新日期:1981-02-23 00:00:00
abstract::Co-activation of group I metabotropic glutamate (mGlu) receptors and adenosine receptors resulted in an augmented cyclic AMP response in primary cultures of rat striatal neurones. L-glutamate and the selective group I agonist, (S)-dihydroxyphenylglycine (S-DHPG) evoked concentration-dependent potentiations of cyclic A...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00094-8
更新日期:1998-04-27 00:00:00
abstract::In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.063
更新日期:2007-09-05 00:00:00
abstract::The lamination of the hippocampus in the homozygous B6CBA weaver mouse (wv/wv) was compared with that in normal B6CBA littermates (+/+) and C57BL/6J mice using Nissl and Timm's staining. In Nissl-stained preparations, the normal littermates exhibit a compact, regular arrangement of pyramidal cells in area CA3 of the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00974-u
更新日期:1995-10-23 00:00:00
abstract:BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.021
更新日期:2006-11-06 00:00:00
abstract::Long-term potentiation (LTP) can be initiated in CA1, but not in the dentate, region of slices from rats with bilateral subcortical deafferentation at 8 week survival time. At about one week survival time, LTP is present in the CA1 region of all and also in the dentate of about 50% of slices. The results suggest that ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90981-g
更新日期:1990-06-04 00:00:00
abstract::Antibody microprobes were used to study the release of immunoreactive neurokinin A into the spinal cord of anaesthetised cats during and following injection of a knee joint with kaolin and carrageenan. A basal level of immunoreactive neurokinin A was detected prior to any noxious stimuli. Innocuous mechanical joint st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91352-h
更新日期:1990-11-19 00:00:00
abstract::Cerebellar Purkinje neurons possess AMPA ((RS)-alpha-amino-3-hydroxyl-5- methyl-4-isoxazolepropionic acid)-sensitive ionotropic glutamate receptors (AMPA GluRs) and ACPD ((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid)-sensitive metabotropic glutamate receptors (mGluRs). The contributions of these receptors to resp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91186-v
更新日期:1993-12-17 00:00:00
abstract::Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.10.062
更新日期:2015-01-21 00:00:00
abstract::There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexua...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91574-5
更新日期:1987-12-08 00:00:00
abstract::The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01256-0
更新日期:1998-01-19 00:00:00
abstract::Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90249-3
更新日期:1976-10-29 00:00:00
abstract::The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91740-x
更新日期:1994-03-14 00:00:00
abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00908-6
更新日期:1997-10-10 00:00:00
abstract::The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91604-q
更新日期:1993-08-13 00:00:00
abstract::We have examined the role of the octopamine-containing buccal OC interneuron in the fictive feeding rhythm generated by depolarizing a modulatory interneuron, SO, in the isolated central nervous system (CNS) of Lymnaea stagnalis. Before stimulating the SO, the initial fictive feeding rate was 2.0+/-0.37 bites/min (mea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02968-1
更新日期:2000-12-22 00:00:00
abstract::The current study was performed to evaluate the mechanisms and therapeutic effects of overexpressing neuroglobin (Ngb) on spinal cord injury (SCI). Adeno-associated virus (AAV) was injected in the T12 section 7 days before SCI. Animals were randomly divided into four groups: a sham group, a vehicle group, an AAV-EGFP ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.03.020
更新日期:2014-05-08 00:00:00
abstract::Recently, cerebral blood flow changes were re-discussed to contribute to tissue protection after preconditioning. In the present study, we demonstrate increased vessel diameters of the leptomeningeal anastomoses after hypoxic preconditioning by visualization of the brain angioarchitecture using the latex perfusion tec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.07.081
更新日期:2006-10-18 00:00:00
abstract::Pouch young opossums aged from 5 to 34 days underwent unilateral eye enucleation and the projection from the remaining eye to the superior colliculus (SC) was explored at maturity by anatomical and physiological methods. The results were compared to data from normal or adult enucleated animals. Analysis of the experim...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90236-1
更新日期:1986-06-01 00:00:00
abstract::Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00658-0
更新日期:1996-10-21 00:00:00
abstract::The divalent cation zinc has been reported to possess several physiological properties such as blocking apoptotic cell death through an inhibitory effect on Ca(2+)-Mg2+ endonuclease activity, or modulating the neurotoxicity via glutamate receptor subtypes. In the present study, we investigated the effect of peripheral...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01112-2
更新日期:1996-12-16 00:00:00
abstract::Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91272-i
更新日期:1990-01-08 00:00:00
abstract::Extracellular recordings of action potentials were made from neurones antidromically identified as neurosecretory cells in the paraventricular and supraoptic nuclei of urethane-anesthetized female rats. Eighty-six neurones were examined for their responsiveness to 10 ng of angiotensin II (AII) injected into the third ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90048-7
更新日期:1980-04-28 00:00:00