Abstract：
:Antibody microprobes were used to study the release of immunoreactive neurokinin A into the spinal cord of anaesthetised cats during and following injection of a knee joint with kaolin and carrageenan. A basal level of immunoreactive neurokinin A was detected prior to any noxious stimuli. Innocuous mechanical joint stimuli (flexion or pressure) did not alter this basal level of release. However, on injection of kaolin and carrageenan into a knee joint, evidence of release into the ipsilateral spinal cord was immediately observed. Initially, immunoreactive neurokinin A was detected in 2 regions: one at the dorsal surface of the spinal cord and the other centred on the superficial dorsal horn. Within 1 h of joint injection, however, immunoreactive neurokinin A was detected throughout the dorsal horn and the adjacent white matter. The extensive spread and persistence of immunoreactive neurokinin A in the spinal cord may underlie some of the prolonged excitability changes evoked by brief noxious stimuli and peripheral inflammation reported by other laboratories.
journal_name
Brain Resjournal_title
Brain researchauthors
Hope PJ,Jarrott B,Schaible HG,Clarke RW,Duggan AWdoi
10.1016/0006-8993(90)91352-hsubject
Has Abstractpub_date
1990-11-19 00:00:00pages
292-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91352-Hjournal_volume
533pub_type
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