Abstract：
:Mice pretreated with the benzodiazepine antagonist, CGS 8216 (2.5, 10, or 40 mg/kg, i.p.) learned a T-maze discrimination to a fixed performance criterion more rapidly than vehicle-treated mice. In retention tests conducted one week later, the drug-treated groups had better first-trial recall and greater difficulty reversing the previously trained maze habit when compared with controls, suggesting improved memory for the previously trained maze habit. The enhanced acquisition and retention following CGS 8216 was similar to that observed previously with another benzodiazepine antagonist, flumazenil (Ro 15-1788). It is postulated that CGS 8216 and flumazenil could act at benzodiazepine receptors to antagonize a tonic inhibitory influence of endogenous, diazepam-like, benzodiazepine receptor ligands on memory processes.
journal_name
Brain Resjournal_title
Brain researchauthors
Kumar BA,Forster MJ,Lal Hdoi
10.1016/0006-8993(88)91223-1subject
Has Abstractpub_date
1988-09-13 00:00:00pages
195-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)91223-1journal_volume
460pub_type
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