Abstract：
:Aquaporins (AQPs) are membrane proteins that facilitate water transport across biological membranes and are essential for the proper function of neural tissue. Although AQPs have been extensively studied in mammalian retina, their presence in lower vertebrate retina is less frequently characterized. AQP4 expressed in mammalian and chick Müller cells plays a major part in maintaining retinal homeostasis. In this study, we examined the immunoreactivity of AQP4 in the adult retina of gilthead sea bream (Sparus aurata-teleost fish), during light and dark adaptation. The AQP4 expression was detected in Müller cell somas at the inner nuclear layer and in the end-feet processes near the vitreoretinal border. Moreover, AQP4 was also evident in cone photoreceptor cells and in a GABAergic subpopulation of amacrine cells (AQP4-ACs). Four different types of AQP4-ACs were characterized based on their morphology and dendrite stratification. Interestingly, a stronger AQP4 immunoreactivity was observed in the inner nuclear layer during dark adaptation, accompanied by a significant increment in AQP4-ACs cell size. Hence, AQP4 may play an important role in water distribution in the teleost fish retina.
journal_name
Brain Resjournal_title
Brain researchauthors
Hombrebueno JR,Lee EJ,Martínez-Ruiz N,García-Alcázar A,Grzywacz NM,De Juan Jdoi
10.1016/j.brainres.2011.11.014subject
Has Abstractpub_date
2012-01-13 00:00:00pages
46-55eissn
0006-8993issn
1872-6240pii
S0006-8993(11)02041-5journal_volume
1432pub_type
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