Abstract：
:Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium channels in CGRP secretion and are consistent with a role for the peptide as an extracellular neuromodulator in the sensory nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Peterfreund RA,Vale WWdoi
10.1016/0006-8993(86)91441-1subject
Has Abstractpub_date
1986-08-13 00:00:00pages
159-61issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)91441-1journal_volume
380pub_type
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