Studies on the relationship between Ca2+ efflux from mitochondria and the release of amino acid neurotransmitters.

Abstract:

:It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect of DNP and FCCP, uncouplers of oxidative phosphorylation, and quinidine, known to induce muscle contractures and increase Ca2+ efflux from muscle mitochondria, on both [14C]glutamic acid and [3H]GABA unstimulated release from synaptosomes and loss of 45Ca2+ from preloaded whole brain mitochondria. Results showed that the spontaneous efflux of non-putative neurotransmitters, leucine and alpha-aminoisobutyric acid, was less affected or not stimulated at all, under similar experimental conditions. Data suggest that calcium ions released from mitochondria are able to trigger neurotransmitter release.

journal_name

Brain Res

journal_title

Brain research

authors

Sandoval ME

doi

10.1016/0006-8993(80)90618-6

subject

Has Abstract

pub_date

1980-01-13 00:00:00

pages

357-67

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(80)90618-6

journal_volume

181

pub_type

杂志文章
  • Traumatic brain injury produces impairments in long-term and recent memory.

    abstract::Traumatic brain injury (TBI) in humans typically produces neurological suppression and a longer lasting impairment of memory clinically defined as post-traumatic amnesia. An animal model that reliably reproduces the physiological changes associated with TBI was used to assess the memory deficits following brain injury...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91014-j

    authors: Gorman LK,Shook BL,Becker DP

    更新日期:1993-06-18 00:00:00

  • Treatment with deferoxamine increases neurons from neural stem/progenitor cells.

    abstract::Neural transplantation is a promising approach for treating neurodegenerative disease. Neural stem/progenitor cells (NPCs) are self-renewing and multipotent and thus are good candidates for donor cells when they have been clearly defined to differentiate into neurons. As neuronal differentiation follows cell cycle exi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.02.046

    authors: Kim HJ,Hida H,Jung CG,Miura Y,Nishino H

    更新日期:2006-05-30 00:00:00

  • Burst discharges of thalamic reticular neurons: an intracellular analysis in anesthetized rats.

    abstract::In order to analyze the mechanism of burst discharges intracellular recordings were made from 27 somatosensory thalamic reticular (S-TR) neurons in urethane-anesthetized rats. Burst discharges, composed of 2-7 spikes, were always superposed on a slow depolarization (SD) lasting for 40-60 ms, which appeared only when t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90539-8

    authors: Sumitomo I,Takahashi Y,Kayama Y,Ogawa T

    更新日期:1989-03-13 00:00:00

  • Long-lasting handling affects behavioural reactivity in adult rats of both sexes prenatally exposed to diazepam.

    abstract::Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02462-3

    authors: Cannizzaro C,Martire M,Cannizzaro E,Provenzano G,Gagliano M,Carollo A,Mineo A,Steardo L

    更新日期:2001-06-22 00:00:00

  • Topography of cholinergic perikarya and nerve fibres as well as cholinergic vesicles in the rat duodenum.

    abstract::Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90100-3

    authors: Wolter HJ

    更新日期:1985-07-29 00:00:00

  • Modeling Huntington׳s disease with patient-derived neurons.

    abstract::Huntington׳s Disease (HD) is a fatal neurodegenerative disorder caused by expanded polyglutamine repeats in the Huntingtin (HTT) gene. While the gene was identified over two decades ago, it remains poorly understood why mutant HTT (mtHTT) is initially toxic to striatal medium spiny neurons (MSNs). Models of HD using n...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2015.10.001

    authors: Mattis VB,Svendsen CN

    更新日期:2017-02-01 00:00:00

  • Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions.

    abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01315-7

    authors: Kubek MJ,Shih TM,Meyerhoff JL

    更新日期:1997-02-07 00:00:00

  • Renormalization of regional brain blood flow during prolonged mild hypoxic exposure in rats.

    abstract::In this study, we measured regional brain blood flow (BF) in rats during hypoxic exposure. Our data show the hypoxia-induced brain blood flow increase returned to baseline within 1 week as blood hemoglobin increased. Because this return to baseline occurred before capillary angiogenesis, this result suggests that the ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.08.046

    authors: Xu K,Puchowicz MA,LaManna JC

    更新日期:2004-11-19 00:00:00

  • Rat olfactory neurons express a 200 kDa neurofilament.

    abstract::Neurofilament expression in peripheral olfactory neurons of adult rats was investigated by immunoblotting and immunohistochemistry using monoclonal antibodies specific for each of the 3 neurofilament proteins. Immunoblotting analysis of olfactory epithelium extracts demonstrated the presence of only the 200 kDa (NFH) ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90416-s

    authors: Bruch RC,Carr VM

    更新日期:1991-05-31 00:00:00

  • The projection to the mesencephalon from the dorsal column nuclei. An anatomical study in the cat.

    abstract::The terminal areas and cells of origin of the projection from the dorsal column nuclei to the mesencephalon were investigated by the intra-axonal transport method. Following injection of wheat germ agglutinin-horseradish peroxidase conjugate into the dorsal column nuclei, anterograde labeling was observed in several r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90086-6

    authors: Wiberg M,Blomqvist A

    更新日期:1984-10-08 00:00:00

  • Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain.

    abstract::Reduced glutathione (GSH) plays an important role in cellular protection against damage from free radicals and other electrophiles. GSH in the rat central nervous system was quantitatively analyzed. In adult brain, tissue from the cerebellum and cerebrum had higher GSH levels than that from the brainstem and spinal co...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90178-e

    authors: Kudo H,Kokunai T,Kondoh T,Tamaki N,Matsumoto S

    更新日期:1990-03-19 00:00:00

  • Strain differences in the behavioral responses of male rats to chronically administered methylphenidate.

    abstract::Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as amphetamine and cocaine have been reported. However, genetic differences in the locomotor responses of rat strains to methylphenidate (MPD), a commonly used psychostimulant in the treatment of attention deficit/hyperac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04240-3

    authors: Yang PB,Amini B,Swann AC,Dafny N

    更新日期:2003-05-09 00:00:00

  • Effect of substantia nigra stimulation on identified neurons in the VL-VA thalamic complex: comparison between intact and chronically decorticated cats.

    abstract::The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90793-x

    authors: Deniau JM,Lackner D,Feger J

    更新日期:1978-04-21 00:00:00

  • Somatostatin levels in the central nervous system of the Snell dwarf mouse; is somatostatin excess the primary molecular defect in the dw/dw dwarfism?

    abstract::The Snell dwarf mouse (dw/dw) shows significantly decreased somatostatin levels in the hypothalamus whereas more or less increased somatostatin concentrations are observed in any central extrahypothalamic sites studied. These opposite results in hypothalamus and extrahypothalamic areas may be linked to the apparently ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91337-x

    authors: Fuhrmann G,Di Scala-Guenot D,Ebel A

    更新日期:1985-02-25 00:00:00

  • The level of prepulse inhibition in healthy individuals may index cortical modulation of early information processing.

    abstract::This study examined whether baseline PPI levels reflect individual efficiency in tasks associated with routine versus supervisory attentional systems (SAS). PPI and neuropsychological data were collected from 30 healthy male subjects. High PPI was associated with shorter movement times on the 5-choice Reaction Time an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.01.056

    authors: Giakoumaki SG,Bitsios P,Frangou S

    更新日期:2006-03-17 00:00:00

  • Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny.

    abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03282-1

    authors: Cannizzaro C,Martire M,Steardo L,Cannizzaro E,Gagliano M,Mineo A,Provenzano G

    更新日期:2002-10-25 00:00:00

  • Equal effects of typical environmental and specific social enrichment on posttraumatic cognitive functioning after fimbria-fornix transection in rats.

    abstract::Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.10.019

    authors: Gajhede Gram M,Gade L,Wogensen E,Mogensen J,Malá H

    更新日期:2015-12-10 00:00:00

  • The endogenous lectin RL-29 is transynaptically induced in dorsal horn neurons following peripheral neuropathy in the rat.

    abstract::Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90271-n

    authors: Cameron AA,Dougherty PM,Garrison CJ,Willis WD,Carlton SM

    更新日期:1993-08-20 00:00:00

  • Sodium valproate decreases synaptic potentiation and epileptiform activity in hippocampus.

    abstract::The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90678-6

    authors: Griffith WH,Taylor L

    更新日期:1988-11-22 00:00:00

  • In situ appearance of the cold-stable microtubules in the growing axons of the tectal plate of mouse investigated immunocytochemically after polyethyleneglycol (PEG) embedding.

    abstract::Tubulin immunostaining of semi-thin sections after polyethylene glycol embedding was used in the tectal plate of the embryonic mouse at 10 days postmating to analyze the effects of cold treatment on the microtubules of the different cell types seen at this stage. Three sets of microtubules are observed. In the radiall...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90021-6

    authors: Cohen E,Binet S,Meininger V

    更新日期:1987-12-01 00:00:00

  • Kainic acid responses and toxicity show pronounced Ca2+ dependence.

    abstract::Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90989-8

    authors: Hori N,Ffrench-Mullen JM,Carpenter DO

    更新日期:1985-12-09 00:00:00

  • Striatal dopamine metabolism in living monkeys examined by positron emission tomography.

    abstract::Positron emission tomography, using the dopa analogue [18F]6-fluoro-L-dopa, has been used to depict the neostriatum in living monkeys. The amount of 18F that accumulated preferentially in the striatum could be augmented by a peripheral decarboxylase inhibitor. Striatal 18F could also be discharged with reserpine. This...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)91187-3

    authors: Garnett S,Firnau G,Nahmias C,Chirakal R

    更新日期:1983-11-28 00:00:00

  • Responses of rat lateral hypothalamic neuron activity to vestibular nuclei stimulation.

    abstract::Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90653-6

    authors: Katafuchi T,Puthuraya KP,Yoshimatsu H,Oomura Y

    更新日期:1987-01-01 00:00:00

  • Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats.

    abstract::Vascular dysfunction is important in the pathogenesis of peripheral complications of diabetes. However, the effects of diabetes on cerebral blood flow and the role of vascular deficits in the pathogenesis of diabetic encephalopathy are still unknown. The present study examined whether experimental diabetes is associat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04211-7

    authors: Manschot SM,Biessels GJ,Cameron NE,Cotter MA,Kamal A,Kappelle LJ,Gispen WH

    更新日期:2003-03-21 00:00:00

  • The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat.

    abstract::Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90826-8

    authors: Racine RJ,Paxinos G,Mosher JM,Kairiss EW

    更新日期:1988-06-28 00:00:00

  • Immediate or delayed mild hypothermia prevents focal cerebral infarction.

    abstract::The protective effect of mild hypothermia was studied in rodent models of both permanent and transient focal cerebral ischemia. In Expt. 1, Wistar rats were exposed to 6 h permanent ischemia by bilateral occlusion of both common carotid arteries and right middle cerebral artery. In Expt. 2, animals were exposed to 3 h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91428-h

    authors: Xue D,Huang ZG,Smith KE,Buchan AM

    更新日期:1992-07-31 00:00:00

  • Postnatal development of cat superior colliculus. I. Presumptive neurons, immature neurons and degenerating cells in the intermediate and deep layers.

    abstract::Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(84)90013-0

    authors: Warton SS,Jones DG

    更新日期:1984-05-01 00:00:00

  • Neuroprotection and immunomodulation in the gut of parkinsonian mice with a plasmalogen precursor.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons alon...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146460

    authors: Nadeau J,Smith T,Lamontagne-Proulx J,Bourque M,Al Sweidi S,Jayasinghe D,Ritchie S,Di Paolo T,Soulet D

    更新日期:2019-12-15 00:00:00

  • Alzheimer amyloid beta/A4 peptide binding sites and a possible 'APP-secretase' activity associated with rat brain cortical membranes.

    abstract::We carried out ligand binding experiments on membranes from rat brain cortical grey matter using radioiodinated beta/A4 8-17, with non-specific binding determined by the addition of 10 microM unlabelled peptide. Specific, reversible binding amounted to 60-75% of total binding and showed a clear dependence on time, tem...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90905-b

    authors: Allsop D,Yamamoto T,Kametani F,Miyazaki N,Ishii T

    更新日期:1991-06-14 00:00:00

  • Cerebellar benzodiazepine receptors: cellular localization and consequences of neurological mutations in mice.

    abstract::The distribution of cerebellar [3H]flunitrazepam binding sites was studied autoradiographically in Purkinje cell degeneration (pcd/pcd), weaver (wv/wv), staggerer (sg/sg) and reeler (rl/rl) mutant mice. In the normal 78-day-old C57BL/6J mouse cerebellum, the highest concentration of [3H]flunitrazepam binding sites was...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90920-1

    authors: Rotter A,Frostholm A

    更新日期:1988-03-15 00:00:00