Studies on the relationship between Ca2+ efflux from mitochondria and the release of amino acid neurotransmitters.


:It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect of DNP and FCCP, uncouplers of oxidative phosphorylation, and quinidine, known to induce muscle contractures and increase Ca2+ efflux from muscle mitochondria, on both [14C]glutamic acid and [3H]GABA unstimulated release from synaptosomes and loss of 45Ca2+ from preloaded whole brain mitochondria. Results showed that the spontaneous efflux of non-putative neurotransmitters, leucine and alpha-aminoisobutyric acid, was less affected or not stimulated at all, under similar experimental conditions. Data suggest that calcium ions released from mitochondria are able to trigger neurotransmitter release.


Brain Res


Brain research


Sandoval ME




Has Abstract


1980-01-13 00:00:00














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    pub_type: 杂志文章


    authors: Gorman LK,Shook BL,Becker DP

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  • Treatment with deferoxamine increases neurons from neural stem/progenitor cells.

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    authors: Kim HJ,Hida H,Jung CG,Miura Y,Nishino H

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    journal_title:Brain research

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    authors: Sumitomo I,Takahashi Y,Kayama Y,Ogawa T

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    abstract::Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...

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    authors: Cannizzaro C,Martire M,Cannizzaro E,Provenzano G,Gagliano M,Carollo A,Mineo A,Steardo L

    更新日期:2001-06-22 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wolter HJ

    更新日期:1985-07-29 00:00:00

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    journal_title:Brain research

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    authors: Xu K,Puchowicz MA,LaManna JC

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    journal_title:Brain research

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    authors: Bruch RC,Carr VM

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  • The projection to the mesencephalon from the dorsal column nuclei. An anatomical study in the cat.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wiberg M,Blomqvist A

    更新日期:1984-10-08 00:00:00

  • Quantitative analysis of glutathione in rat central nervous system: comparison of GSH in infant brain with that in adult brain.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kudo H,Kokunai T,Kondoh T,Tamaki N,Matsumoto S

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    authors: Yang PB,Amini B,Swann AC,Dafny N

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    authors: Deniau JM,Lackner D,Feger J

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    authors: Fuhrmann G,Di Scala-Guenot D,Ebel A

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    authors: Griffith WH,Taylor L

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    pub_type: 杂志文章


    authors: Cohen E,Binet S,Meininger V

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    authors: Hori N,Ffrench-Mullen JM,Carpenter DO

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Katafuchi T,Puthuraya KP,Yoshimatsu H,Oomura Y

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  • Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats.

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    pub_type: 杂志文章


    authors: Manschot SM,Biessels GJ,Cameron NE,Cotter MA,Kamal A,Kappelle LJ,Gispen WH

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  • The effects of various lesions and knife-cuts on septal and amygdala kindling in the rat.

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    journal_title:Brain research

    pub_type: 杂志文章


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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Xue D,Huang ZG,Smith KE,Buchan AM

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  • Postnatal development of cat superior colliculus. I. Presumptive neurons, immature neurons and degenerating cells in the intermediate and deep layers.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Warton SS,Jones DG

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    pub_type: 杂志文章


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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Allsop D,Yamamoto T,Kametani F,Miyazaki N,Ishii T

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rotter A,Frostholm A

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