Abstract：
:Using a co-culture model, we showed that diffusible factors from arcuate nucleus (AN) specifically increased the number and the size of hypothalamic neurons producing melanin-concentrating hormone (MCH). In this model neurite outgrowth and contacts between MCH neurons and dopaminergic neurons were also prominently increased, as compared to control lateral areas of the posterior hypothalamus (LH) primary cultures. These effects were mediated in part by AN glia but also by neurons of both fetal and adult AN. AN glia produced diffusible factor(s) mainly responsible for an important MCH neurite outgrowth and expressed inhibiting factors, preventing the adhesion of LH cells on AN glial cells. Furthermore, we report here a nerve growth factor-like effect from Broca's diagonal band on MCH hypothalamic neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Compagnone N,Fellmann D,Bugnon C,Jaquemard Cdoi
10.1016/0006-8993(93)90948-msubject
Has Abstractpub_date
1993-11-19 00:00:00pages
137-44issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90948-Mjournal_volume
628pub_type
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