Abstract：
:Transforming growth factor beta (TGFbeta) modulates a variety of growth related functions following traumatic injury. The cellular response to TGFbeta is predominantly mediated through TGFbeta receptor I (TGFbetaRI) and receptor II (TGFbetaRII) on the cell surface and SMAD proteins intracellularly. We investigated the expression of TGFbeta receptors in the acute and chronic phases of a traumatic cerebral injury (TCI) by immunohistochemistry and in cultures of murine brain microvascular endothelial (EN) cells using cytofluorimetry. Here, we report that TGFbetaRII expression significantly increases on brain endothelial cells in the chronic phase of TCI. SMAD3 and SMAD4 protein expression were also upregulated suggesting the activation of TGFbeta receptor intracellular signaling. When TGFbetaRI and TGFbetaRII expression was studied in in vitro cultures of murine brain microvessel EN cells, TGFbetaRII showed increased expression on proliferating cells that are incorporating BrdU. These data show a differential expression of TGFbetaRI and TGFbetaRII on brain microvessel EN cells in the acute and chronic phases of TCI that might be associated with EN proliferation following injury.
journal_name
Brain Resjournal_title
Brain researchauthors
Fee DB,Sewell DL,Andresen K,Jacques TJ,Piaskowski S,Barger BA,Hart MN,Fabry Zdoi
10.1016/j.brainres.2004.03.028subject
Has Abstractpub_date
2004-06-25 00:00:00pages
52-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304004767journal_volume
1012pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.060
更新日期：2013-07-03 00:00:00
abstract：:The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90894-6
更新日期：1983-05-16 00:00:00
abstract：:Parvalbumin (PV)-immunoreactive neurons in rat neostriatum were studied under light and electron microscopes. A small number of neurons in the striatum were immunoreactive for PV (a Ca-binding protein). Most of them were also strongly immunoreactive for glutamate decarboxylase but were negative for NADPH-diaphorase ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90002-s
更新日期：1990-12-17 00:00:00
abstract：:In animals with retinal degeneration, the presence of activated microglial cells in the outer retina during the early stages of injury suggests that they may be involved in the ensuing photoreceptor cell death. In the following study, we investigated the effects of rat retina-derived microglial cells on a photorecepto...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01625-x
更新日期：1999-07-31 00:00:00
abstract：:The ultrastructural morphology and synaptic associations between enkephalin-containing neurons and sensory afferents was examined in the caudalis portion of rat spinal trigeminal complex, the region corresponding to Rexed's layer II of the dorsal horn. Specific antiserum to Met5-enkephalin was localized by the peroxid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90580-7
更新日期：1982-09-30 00:00:00
abstract：:Decision making is commonly conceived to reflect the interplay of mutually antagonistic systems: executive processes must inhibit affective information to make adaptive choices. Consistent with this interpretation, prior studies have shown that the dorsolateral prefrontal cortex (dlPFC) is activated by executive proce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.04.026
更新日期：2011-06-13 00:00:00
abstract：:Phosphocreatine-Mg-complex acetate (PCr-Mg-CPLX) is a creatine-derived compound that in previous in vitro research was able to increase neuronal creatine independently of the creatine transporter, thus providing hope to cure the hereditary syndrome of creatine transporter deficiency. In previous research we showed tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.009
更新日期：2009-08-18 00:00:00
abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.017
更新日期：2005-02-28 00:00:00
abstract：:Microencephalic rats induced by methylazoxymethanol (MAM) were observed to have notable hyperactivity compared to control rats, as measured by several behavioral parameters in an automated field apparatus. Acute injection of the stimulant drug, methamphetamine (MAP), produced an increase in the incidence of locomotion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01307-4
更新日期：1995-01-23 00:00:00
abstract：:The cloned 5-HT3 receptor from NCB-20 neuroblastoma cells was expressed in Xenopus oocytes. In these oocytes, 5-HT, the selective 5-HT3 receptor agonists, 2-methyl-5-HT and m-chlorophenylbiguanide activated an inward current which was sensitive to the specific 5-HT3 receptor antagonist LY278584. Cocaine (0.1 to 10 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01316-a
更新日期：1995-03-06 00:00:00
abstract：:Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90060-5
更新日期：1988-04-01 00:00:00
abstract：:Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91160-3
更新日期：1991-04-12 00:00:00
abstract：:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90087-9
更新日期：1988-01-01 00:00:00
abstract：:Following unilateral destruction of the entorhinal cortical region of the adult rat, the denervated granule cells of the dentate gyrus are reinnervated as a result of the proliferation of a pathway from the surviving contralateral entorhinal area. The present study investigates the cells of origin of this lesion-induc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90837-5
更新日期：1978-05-26 00:00:00
abstract：:Tissue culture preparations of the myenteric plexus from the guinea pig taenia coli have been studied by electron microscopy. Three main cell types can be identified: neurons, enteric glial cells and fibroblasts. The ultrastructure of these cells resembles that of the same cells in situ. Neuronal processes form close ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90467-5
更新日期：1983-02-28 00:00:00
abstract：:Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhibiting glutamate uptake. This model has also been used to ide...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.030
更新日期：2009-02-27 00:00:00
abstract：:Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90771-x
更新日期：1976-07-30 00:00:00
abstract：:To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90205-5
更新日期：1983-12-01 00:00:00
abstract：:Mutant Cu/Zn superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) causes selective motor neuron loss through unknown mechanisms of cell damage. Damaged neurons frequently undergo apoptosis mediated by the p53 cell survival regulator. We therefore studied whether motor neuron diseas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02745-1
更新日期：2000-10-06 00:00:00
abstract：:Humans rely on the integration of information from multiple sensory modalities to interact successfully with their environment. In the present series of studies, we investigated how the visuomotor system integrates congruent and incongruent visual and tactile sensory inputs for goal-directed action comprehension and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.081
更新日期：2008-11-25 00:00:00
abstract：:Schwann cell is a cell type that forms myelin sheath and provides trophic supports for neuronal cells by producing neurotrophic factors such as neurotrophins and neurokines in both normal and traumatic situations. It was recently reported that after lesion of sciatic nerve, mRNA for cholinergic differentiation factor ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01015-9
更新日期：1997-11-21 00:00:00
abstract：:The effects of bilateral intracranial injections of the D-1 dopamine receptor antagonist SCH 23390 HCl (0, 0.8, 1.6, 3.2, and 6.4 microgram total bilateral dose) administered into the dorsolateral bed nucleus of the stria terminalis (dlBNST) immediately prior to a 3 h intravenous cocaine self-administration session we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01190-6
更新日期：1998-02-16 00:00:00
abstract：:The present study was designed to assess the effect of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) on desensitization of Torpedo acetylcholine (ACh) receptors by analyzing summated macroscopic currents in an outside-out patch-clamp configuration. Normal ACh receptors desensitized with a fast (6 ms) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00836-1
更新日期：1998-11-23 00:00:00
abstract：:The purpose of this study was to determine the effects of aging and gender on the volumes of total brain, brainstem, cerebellum and lateral ventricle of healthy Koreans by magnetic resonance imaging (MRI). Using three-dimensional MRI volumetry, we compared the volumes of various brain regions according to age and gend...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.04.027
更新日期：2009-06-18 00:00:00
abstract：:The effect of aging on the properties of N-methyl-D-aspartate (NMDA) receptors in the forebrain of female NMRI mice was investigated using the antagonist [3H]MK-801 as radioligand. Compared to young (3 months) mice, aged (20 months) mice showed changes of the properties of the NMDA receptor at three different levels: ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90892-d
更新日期：1992-07-03 00:00:00
abstract：:The link between the immunolocalization of apolipoproteins E (apo E) and J (apo J) and the different severity of beta-amyloid deposition in various areas of Alzheimer's disease (AD) and Down's syndrome (DS) brain was analyzed. Both apolipoproteins were found in all types of senile plaques (SPs) in the cerebral cortex,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00482-6
更新日期：1995-07-10 00:00:00
abstract：:Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion. Electrophysiological studies at central nervous system synapses of Rab3A null-mutant mice have indicated that nerve stimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.055
更新日期：2006-05-17 00:00:00
abstract：:In WAG/Rij rat genetic model of absence epilepsy, the first spike-wave discharges (EEG hallmark of absence epilepsy) are known to appear after puberty, and their incidence increases with age. WAG/Rij rats are known to have a genetic predisposition to absence epilepsy, and further development of epilepsy might be influ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.067
更新日期：2015-01-12 00:00:00
abstract：:The experimental evidence linking glutamate to ischemic neuronal injury is derived from in vitro or in vivo animal stroke models. We, therefore, developed an in vitro preparation to determine whether glutamate contributes to early neuronal swelling in oxygen and glucose deprived (OGD) human neocortical slices. In orde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01286-9
更新日期：1998-01-26 00:00:00
abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01077-3
更新日期：1997-01-02 00:00:00
