Abstract：
:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
journal_name
Brain Resjournal_title
Brain researchauthors
Whitehouse PJ,Martino AM,Antuono PG,Lowenstein PR,Coyle JT,Price DL,Kellar KJdoi
10.1016/0006-8993(86)90819-xsubject
Has Abstractpub_date
1986-04-16 00:00:00pages
146-51issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(86)90819-Xjournal_volume
371pub_type
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