P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.

abstract：:The effects of the GABAA agonist, isoguvacine, on NMDA-induced burst firing of substantia nigra dopaminergic neurons were studied with intracellular and whole cell recordings in vitro. NMDA application caused the neurons to fire in rhythmic bursts. Although the NMDA-induced bursty firing pattern was insensitive to hyp...

journal_title：Brain research

authors： Paladini CA,Iribe Y,Tepper JM

更新日期：1999-06-19 00:00:00

abstract：:Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with deficits in fluid reasoning, which may be related to self-regulation of cognition and behavior, and requires intact attention, working memory, and inhibition skills. No functional magnetic resonance imaging (fMRI) studies have directly examined fluid r...

journal_title：Brain research

authors： Tamm L,Juranek J

更新日期：2012-07-17 00:00:00

abstract：:Biocytin is useful for intracellular filling in living slices because it is soluble, has high electrophoretic mobility and a high affinity for avidin. In fixed slices, however, membrane potential cannot be used to signify that a cell is impaled. Thus, it is necessary to inject a fluorescent molecule so that impalement...

journal_title：Brain research

authors： Liu WL,Behbehani MM,Shipley MT

更新日期：1993-04-09 00:00:00

abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...

journal_title：Brain research

authors： Marks N,Stern F,Lajtha A

更新日期：1975-03-21 00:00:00

abstract：:The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...

journal_title：Brain research

authors： Miller JP,Rall W,Rinzel J

更新日期：1985-01-28 00:00:00

abstract：:We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a con...

journal_title：Brain research

authors： Lee BK,Lee DH,Park S,Park SL,Yoon JS,Lee MG,Lee S,Yi KY,Yoo SE,Lee KH,Kim YS,Lee SH,Baik EJ,Moon CH,Jung YS

更新日期：2009-01-12 00:00:00

abstract：:The effects of two kinds of antibiotics, minocycline (MNC) and ampicillin (AB-PC), on human sleep were investigated on 19 healthy male students to test for a relationship between human sleep and protein synthesis. These drugs and placebos were capsulated identically in appearance and were given to the subjects using t...

journal_title：Brain research

authors： Nonaka K,Nakazawa Y,Kotorii T

更新日期：1983-12-12 00:00:00

abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...

journal_title：Brain research

authors： Pigott R,Kelly JS

更新日期：1986-09-01 00:00:00

abstract：:The purpose of this study was to determine which myelinated cutaneous receptor populations in cat are responsive to a stimulus (cowhage) that produces unambiguous pruritus in human subjects. Initial experiments using electrocutaneous stimuli demonstrated that fibers conducting as slowly as 1.5 m/s could be recorded fr...

journal_title：Brain research

authors： Tuckett RP,Wei JY

更新日期：1987-06-09 00:00:00

abstract：:In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...

journal_title：Brain research

authors： Lai CH,Chan YS

更新日期：1995-09-25 00:00:00

abstract：:Cultured cells derived from Tay-Sachs disease (TSD) fetal cerebellum were shown to accumulate GM2 ganglioside when compared with control cultures. In contrast, fibroblasts derived from TSD fetal lung do not contain GM2. GM2 was identified by thin-layer chromatography (TLC) and confirmed by gas-liquid chromatography (G...

journal_title：Brain research

authors： Hoffman LM,Amsterdam D,Schneck L

更新日期：1976-07-23 00:00:00

abstract：:Modulation of gamma-aminobutyric acid (GABA)-mediated inhibition, and glutamate-mediated excitation by highly selective mu and delta opioid agonists was studied using intracellular recordings of CA1 pyramidal neuron synaptic responses in superfused hippocampal slices. Equimolar concentrations of the selective mu agoni...

journal_title：Brain research

authors： Lupica CR,Proctor WR,Dunwiddie TV

更新日期：1992-10-16 00:00:00

abstract：:The effects of ricin (RCA-120) on non-injected dorsal root ganglion (DRG) cells, sharing the same DRG as the injected ones, were studied after ricin injections into the tibial nerve and B-HRP injections into the peroneal nerve. Numerous DRG cells containing B-HRP reaction product and exhibiting signs of advanced degen...

journal_title：Brain research

authors： Rivero-Melián C,Arvidsson J

更新日期：1990-02-19 00:00:00

abstract：:Previous studies have shown that muscarinic cholinergic agonists bind to 3 distinct receptor sites in brain, each being distinguished by their affinity for the agonists. Antagonists, on the other hand, bind to these sites with the same high affinity. The relative concentrations of the two high and the low affinity ago...

journal_title：Brain research

authors： Wamsley JK,Zarbin MA,Birdsall NJ,Kuhar MJ

更新日期：1980-10-27 00:00:00

abstract：:Stimulation of spinal serotonin (5-HT)(2A/2C) receptors has previously been reported to lead to either a pro-nociceptive or an anti-nociceptive response. Behavioral data have indicated that the pro-nociceptive effect is related to the release of substance P (SP). The aim of this in vivo microdialysis study was to inve...

journal_title：Brain research

authors： Kjørsvik Bertelsen A,Warsame Afrah A,Gustafsson H,Tjølsen A,Hole K,Stiller CO

更新日期：2003-10-10 00:00:00

abstract：:Methamphetamine (METH) is one of the most commonly abused psychostimulant, and is known to induce dopaminergic neurotoxicity by generating oxidative stress and free radicals. In the present study we investigated the effects of METH on egr-1 and c-fos immediate early gene induction in different regions of mouse brain, ...

journal_title：Brain research

authors： Thiriet N,Zwiller J,Ali SF

更新日期：2001-11-16 00:00:00

abstract：:While it is generally assumed that cocaine self-administration (SA) is determined and maintained by the pharmacological actions of cocaine in the brain, it is also a drug-motivated and drug-reinforced goal-directed behavior, which is determined by concurrent learning and behavioral performance. To dissociate the contr...

journal_title：Brain research

authors： Kiyatkin EA,Brown PL

更新日期：2004-04-16 00:00:00

abstract：:The effect of bombesin on the activity of dopamine (DA) neurons comprising the nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophysial systems in the male rat was determined by measuring: (1) the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after administration of a decarboxylase inhibitor, and (2) th...

journal_title：Brain research

authors： Manzanares J,Toney TW,Lookingland KJ,Moore KE

更新日期：1991-11-22 00:00:00

abstract：:The mismatch negativity (MMN) event-related potential is elicited by changes in repetitive auditory stimuli. The present paper suggests that: (1) an acoustic model of the auditory environment is maintained even in the absence of attention focussed on auditory stimuli, preattentively detecting repetitive features of th...

journal_title：Brain research

authors： Winkler I,Karmos G,Näätänen R

更新日期：1996-12-02 00:00:00

abstract：:Male Wistar rats were anaesthetized, injected intracisternally (i.c.) with saline or colchicine and were decapitated at various time intervals. Trunk blood was collected for the determination of immunoreactive adrenocorticotropic hormone (ACTHi) by radioimmunoassay (RIA) and of corticosterone by a fluorometric assay. ...

journal_title：Brain research

authors： Berkenbosch F,Tilders FJ

更新日期：1988-03-01 00:00:00

abstract：:The striatum and olfactory tubercle of 30-month-old F344 rats contain significantly (21-24%) less dopamine compared with young adult (8-month) animals. However, rats of the two age groups show identical Km and Vmax values for the kinetics of [3H]dopamine uptake into striatal homogenates; uptake into the olfactory tube...

journal_title：Brain research

authors： Marshall JF,Altar CA

更新日期：1986-07-30 00:00:00

abstract：:The rostral brainstem and thalamus of awake cats were studied for depth correlates of a surface-recorded midlatency auditory evoked potential, wave "A', with a latency range of 17-25 ms. In response to clicks or pure tones, midlatency potentials were recorded from the level of the cuneiform nucleus (14-15 ms latencies...

journal_title：Brain research

authors： Hinman CL,Buchwald JS

更新日期：1983-03-28 00:00:00

abstract：:The responsiveness of the tonically firing single motor units (SMU) to Ia afferent volleys elicited by either mechanical (T-reflex) or electrical nerve stimulation (H-reflex) was tested in the extensor carpi radialis muscle (ECR) while the subjects were maintaining a steady wrist extension force using visual feedback ...

journal_title：Brain research

authors： Nafati G,Rossi-Durand C,Schmied A

更新日期：2004-08-27 00:00:00

abstract：:Oxidative stress has been implicated as a pathogenic mediator of neuronal perikarya cell death. Axons and oligodendrocytes, components of white matter, could also be vulnerable to oxidative damage. An experimental model of oxidative stress was induced by systemic injection of 3-nitropropionic acid (3-NPA). Animals rec...

journal_title：Brain research

authors： McCracken E,Dewar D,Hunter AJ

更新日期：2001-02-23 00:00:00

abstract：:The effects of psychological stress on catecholamine and indoleamine metabolism were examined in various brain regions of rats. Psychologically stressed rats were exposed to emotional responses of foot-shocked rats, but were themselves prevented from receiving foot-shock. Psychological stress for 30 min resulted in si...

journal_title：Brain research

authors： Kaneyuki H,Yokoo H,Tsuda A,Yoshida M,Mizuki Y,Yamada M,Tanaka M

更新日期：1991-08-23 00:00:00

abstract：:The current study was performed to evaluate the mechanisms and therapeutic effects of overexpressing neuroglobin (Ngb) on spinal cord injury (SCI). Adeno-associated virus (AAV) was injected in the T12 section 7 days before SCI. Animals were randomly divided into four groups: a sham group, a vehicle group, an AAV-EGFP ...

journal_title：Brain research

authors： Lan WB,Lin JH,Chen XW,Wu CY,Zhong GX,Zhang LQ,Lin WP,Liu WN,Li X,Lin JL

更新日期：2014-05-08 00:00:00

abstract：:We previously reported that reactive oxygen species (ROS) in paraventricular nucleus (PVN) modulated cardiac sympathetic afferent reflex (CSAR) and mediated the effect of angiotensin II (Ang II) in the PVN on the CSAR. In the present study, we investigated whether the NAD(P)H oxidase in the PVN was a key source of ROS...

journal_title：Brain research

authors： Zhang Y,Yu Y,Zhang F,Zhong MK,Shi Z,Gao XY,Wang W,Zhu GQ

更新日期：2006-04-12 00:00:00

abstract：:The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...

journal_title：Brain research

authors： Garcia-Rill E,Nieto A,Adinolfi A,Hull CD,Buchwald NA

更新日期：1979-07-20 00:00:00

abstract：:cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...

journal_title：Brain research

authors： Yamamoto M,Sobue G,Li M,Mitsuma T,Kimata K,Yamada Y

更新日期：1994-08-08 00:00:00

abstract：:Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation such as the occurrence of glioblastoma (GBM), the most co...

journal_title：Brain research

authors： Shen F,Song C,Liu Y,Zhang J,Wei Song S

更新日期：2019-02-01 00:00:00