Cholinergic and noradrenergic toxicity of intraventricular aluminum chloride in the rat hippocampus.

Abstract:

:The effects of the intraventricular administration of aluminum chloride (AlCl3) on high affinity choline transport (HAChT) and norepinephrine concentration were examined in the hippocampus of the rat. Controlling for osmolarity and pH, the intraventricular administration of AlCl3 resulted in a dose-related reduction in both variables with relative selectivity for HAChT. Moreover, the neurotoxicity of intraventricular aluminum appeared to be dependent on the forms of the aluminum salt administered.

journal_name

Brain Res

journal_title

Brain research

authors

Zubenko GS,Hanin I

doi

10.1016/0006-8993(89)91121-9

subject

Has Abstract

pub_date

1989-10-02 00:00:00

pages

381-4

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)91121-9

journal_volume

498

pub_type

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