Abstract：
:The effects of Morris water maze training on brain metabolism and behavior were compared between aged (20-22 months) and young (2-4 months) Fischer 344 male rats. Each group had yoked controls, which swam the same amount of time as the trained rats but without the platform. This was followed after 9 days by quantitative histochemical mapping of brain cytochrome oxidase, the terminal enzyme for cellular respiration. The aged rats spent a significantly lower percent of time in the correct quadrant and had a longer latency to escape to the hidden platform, relative to the young rats. Metabolic differences between trained aged and young rats were found in regions related to escape under stress: perirhinal cortex, basolateral amygdala and lateral habenula; and vestibular nuclei that guide orientation in three-dimensional space. These differences were not found in the yoked swimming rats. The results suggest that, at the time point investigated, water maze training in aged Fischer 344 rats produces altered oxidative energy metabolism in task-relevant limbic and vestibular regions.
journal_name
Brain Resjournal_title
Brain researchauthors
Villarreal JS,Gonzalez-Lima F,Berndt J,Barea-Rodriguez EJdoi
10.1016/s0006-8993(02)02545-3subject
Has Abstractpub_date
2002-06-07 00:00:00pages
43-51issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302025453journal_volume
939pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Histochemical and immunochemical techniques are used to locate 2',3'-cyclic nucleotide-3'-phosphohydrolase (2',3'-cNMP-3'ase) within cells of the vertebrate retina. A new histochemical method is described which links the hydrolysis of 2',3'-cNADP to the formation of a reduced, insoluble tetrazolium formazan. Photorece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90335-9
更新日期：1983-04-18 00:00:00
abstract：:Previously brain norepinephrine (NE) neurons in the locus coeruleus (LC) have been shown to respond profoundly to external, environmental stimuli and are thought to be involved in behavioral functions such as vigilance, alarm and anxiety reactions to novel and, especially, threatening stimuli. Here we have used electr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90964-9
更新日期：1986-06-04 00:00:00
abstract：:In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.051
更新日期：2011-01-31 00:00:00
abstract：:Cajal-Retzius (CR) cells of the mammalian neocortex co-express the extracellular matrix protein Reelin and p73, a transcription factor involved in cell death and survival. Most neocortical CR cells derive from the cortical hem, with minor additional sources. We analyzed the distribution of Reelin and p73 immunoreactiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.015
更新日期：2007-02-09 00:00:00
abstract：:The concentrations of GABA, glutamate, aspartate, glycine, taurine, glutamine, asparagine and alanine were determined in the CSF of 10 Senegalese baboons (Papio papio) following initial ketamine anaesthesia and subsequent administration (4 h later) of different compounds known to alter either inhibitory or excitatory ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90370-b
更新日期：1991-01-04 00:00:00
abstract：PURPOSE:To determine whether antisense oligonucleotides (AODNs) targeted against CRX, a photoreceptor-specific trans-acting factor, suppress CRX expression and interphotoreceptor retinoid binding protein (IRBP) promoter activity. METHODS:Cultures of human retinoblastoma cells were transfected with chloramphenicol acet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02884-0
更新日期：2001-10-19 00:00:00
abstract：:Central catecholaminergic nerves have been shown to participate in the integration of cardio-cardiac reflexes induced by coronary artery ligation in the rat. In this study we measured the turnover of dopamine, norepinephrine and epinephrine in microdissected brain regions to identify some of the specific neural loci i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91010-1
更新日期：1982-03-11 00:00:00
abstract：:In the present study, we used a repeated restraint stress animal model to observe the changes in the expression of brain-derived neurotrophic factor (BDNF) and B cell lymphoma protein-2 (Bcl-2) in hippocampal neurons of rats, monitored the time course of the expression over 3 weeks post-stress period, and examined the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.089
更新日期：2004-10-29 00:00:00
abstract：:Neuroanatomical and electrophysiological techniques were used to study efferent projections of the gustatory region of the parabrachial nuclei (PBN) in rabbits. Autoradiographic analysis of [3H]leucine microinjected into electrophysiologically defined gustatory areas of the PBN revealed strong projections to the ventr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91061-2
更新日期：1983-01-17 00:00:00
abstract：:The present study examined the locomotor response of rats to unilateral injections of the mixed D1/D2 agonist apomorphine, the D2 agonist quinpirole, and the D1 agonist SKF 38393 into the left or right nucleus accumbens (NA) of male Sprague-Dawley rats. There were 2 main findings. First, unilateral (left or right) inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91351-g
更新日期：1990-11-19 00:00:00
abstract：:The two inbred strains of mice C57BL/6 and DBA/2 are characterized by a different behavioral reactivity to cholinergic agents during development. The present experiment revealed that the strain-dependent differences in cholinergic-mediated analgesia during development disappeared during adult life. In fact, oxotremori...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90743-u
更新日期：1990-02-26 00:00:00
abstract：:Hypothalamic control of thermoregulatory evaporation has been examined in hydrated and dehydrated cats exposed to warm ambient temperatures. Reduction in evaporative cooling during dehydration is associated with increased hypothalamic temperature. Local thermal stimulation of the hypothalamus indicates that the thermo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90120-7
更新日期：1981-02-09 00:00:00
abstract：:The effects of hyperbaric oxygen have been studied on synaptic transmission in the hippocampal brain slice. Oxygen enhances both the prevolley and postsynaptic potential of extracellularly recorded responses following focal stimulation of afferent fiber bundles, but synaptic efficiency is reduced. It is suggested that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90775-8
更新日期：1983-01-31 00:00:00
abstract：:The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90458-4
更新日期：1978-01-27 00:00:00
abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.06.047
更新日期：2015-10-05 00:00:00
abstract：:The glutamate terminals in rat rostral neostriatum were removed on one side by ipsilateral frontal cortical ablation. Intraperitoneal administration of L-methioninesulfoximine (MSO), an inhibitor of glutamine synthetase, induced different changes in amino acid concentration in the rostral neostriatum on the intact and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90261-6
更新日期：1985-07-08 00:00:00
abstract：:The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly understood. In this far-reaching review, we examine what is currently known about ALS genetics and how these genes were initially identified. We also discuss the various types of mutations that might underlie this fatal neurodegenera...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.10.009
更新日期：2015-05-14 00:00:00
abstract：:Smoking is considered the leading cause of preventable death in the United States, but studies in animals suggest that nicotine is only weakly reinforcing. The maintenance of a dangerous habit by a weakly reinforcing agent has been the topic of some dispute. Using a two-lever "choice" self-administration procedure dev...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03215-2
更新日期：2002-01-04 00:00:00
abstract：:Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90906-4
更新日期：1977-01-21 00:00:00
abstract：:In the present functional magnetic resonance imaging (fMRI) study, we aimed to evaluate whether distinct regions of the hippocampus were associated with spatial memory for items presented in different locations of the visual field. In Experiment 1, during the study phase, participants viewed abstract shapes in the lef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.02.029
更新日期：2018-05-15 00:00:00
abstract：:Endogenous acetylcholine (ACh) release from rat striatal slices was measured by a chemiluminescent method. Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU). Morphine, [D-Ala2,Gly(0l)5]-enkephalin (DAGO), [D-Ala2,D-Leu5]-enkephalin (DADLE) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91633-r
更新日期：1990-07-16 00:00:00
abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03766-6
更新日期：2003-04-18 00:00:00
abstract：:Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as amphetamine and cocaine have been reported. However, genetic differences in the locomotor responses of rat strains to methylphenidate (MPD), a commonly used psychostimulant in the treatment of attention deficit/hyperac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04240-3
更新日期：2003-05-09 00:00:00
abstract：:Frequency modulation (FM) is an important building block of complex sounds that include speech signals. Exploring the neural mechanisms of FM coding with computer modeling could help understand how speech sounds are processed in the brain. Here, we modeled the single unit responses of auditory neurons recorded from th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.058
更新日期：2013-11-06 00:00:00
abstract：:Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left ca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.121
更新日期：2006-11-22 00:00:00
abstract：:Studies in regenerating goldfish optic nerves indicate that RNA may be axonally transported during optic nerve regeneration14,18,19. The present study was performed to determine if the axonal migration of RNA could be demonstrated during regeneration of the rat sciatic nerve. Rats, which had only the left sciatic nerv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90652-8
更新日期：1979-04-20 00:00:00
abstract：:The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147069
更新日期：2020-12-01 00:00:00
abstract：:We have previously shown that systemic administration of ondansetron, a selective serotonin type-3 (5-HT3) receptor antagonist, attenuates cholecystokinin (CCK)-induced suppression of food intake. The exact location of 5-HT3 receptors mediating this action is not clear and may involve hindbrain 5-HT3 receptors. In thi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.058
更新日期：2006-08-04 00:00:00
abstract：:A decrease in the number of neuronal profiles in the isocortex of man may be observed on microscopic sections in aging and in degenerative diseases such as Alzheimer's disease. It can be the consequence of a loss of neurons per unit volume or of a reduction of the neuronal volume (i.e. pseudo-loss). This latter possib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91602-8
更新日期：1989-12-11 00:00:00
abstract：:In adult cats, we have investigated how nerve cross-union between slow and fast muscle affects twitch contraction and half-relaxation times in the presence and absence of motor disuse, produced by complete decerebellation. Cerebellectomy abolished the slowing of cross-innervated fast muscle and diminished the amount o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90480-2
更新日期：1982-02-18 00:00:00
