Localization of 2',3'-cyclic nucleotide-3'-phosphohydrolase within the vertebrate retina.

abstract：:In prion diseases, metal imbalances in brain and/or metal substitutions for copper in prion protein suggest that metal-catalyzed oxidation (MCO) and oxidative stress may affect cellular function and accumulation of protease-resistant prion protein (PrP(Sc)). We examined the effect of metal-induced oxidative stress by ...

journal_title：Brain research

authors： Park SJ,Kim NH,Jeong BH,Jin JK,Choi JK,Park YJ,Kim JI,Carp RI,Kim YS

更新日期：2008-10-31 00:00:00

abstract：:The regenerating optic nerve of goldfish first reestablishes a rough retinotopic map on the tectum, then goes through an activity dependent refinement that appears to involve the elimination of inappropriate branches from early regenerated arbors. Retinotopically appropriate branches and synapses may be stabilized bec...

journal_title：Brain research

authors： Schmidt JT,Shashoua VE

更新日期：1988-04-19 00:00:00

abstract：:Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was...

journal_title：Brain research

authors： Johnson EM Jr,Blumberg HM,Costrini NV,Bradshaw RA

更新日期：1979-12-14 00:00:00

abstract：:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...

journal_title：Brain research

authors： Itaya SK

更新日期：1988-01-01 00:00:00

abstract：:We examined protein kinase C gamma-like immunoreactivity (PKCgamma-LI) of trigeminothalamic neurons in the rat medullary dorsal horn (MDH) after injecting a retrograde tracer, Fluoro-Gold (FG), into the thalamus. Over 90% of FG-labeled neurons in the marginal layer (lamina I) and a few FG-labeled neurons in the superf...

journal_title：Brain research

authors： Li YQ,Li JL,Li H,Kaneko T,Mizuno N

更新日期：2001-09-21 00:00:00

abstract：:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons ...

journal_title：Brain research

authors： Agnati LF,Tinner B,Staines WA,Väänänen K,Fuxe K

更新日期：1995-04-03 00:00:00

abstract：:Anxiety is a very common yet poorly understood symptom of Parkinson's disease. We investigated whether Parkinson's disease patients experiencing anxiety share neural mechanisms described in the general population with involvement of critical regions for the control of behaviour and movement. Thirty-nine patients with ...

journal_title：Brain research

authors： Criaud M,Kim JH,Zurowski M,Lobaugh N,Chavez S,Houle S,Strafella AP

更新日期：2021-02-15 00:00:00

abstract：:In the dorsal horn of barbiturate-anaesthetized cats evidence was obtained for a different distribution of enkephalin-preferring and morphine-preferring receptors. When ejected electrophoretically from micropipettes, morphine reduced the nociceptive responses of neurones of laminae IV and V when administered in the su...

journal_title：Brain research

authors： Duggan AW,Johnson SM,Morton CR

更新日期：1981-12-21 00:00:00

abstract：:The functional regulation by dopamine (DA) receptors of serotonin (5-HT) release from the rat substantia nigra (SN) was investigated using in vivo microdialysis. A D1- and D2-receptor-mediated inhibition of nigral 5-HT release was demonstrated in this study. Continuous administration of the D1-receptor agonist CY 2082...

journal_title：Brain research

authors： Thorré K,Sarre S,Smolders I,Ebinger G,Michotte Y

更新日期：1998-06-15 00:00:00

abstract：:The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...

journal_title：Brain research

authors： Canu MH,Langlet C,Dupont E,Falempin M

更新日期：2003-07-18 00:00:00

abstract：:The effects of amphetamine were examined in a brain stimulation reward paradigm in which response rate was measured across a range of stimulation frequencies. Both low (0.0625 and 0.125 mg/kg) and high (1.0, 2.0 and 4.0 mg/kg) doses of systemic amphetamine decreased the stimulation frequency needed to sustain low rate...

journal_title：Brain research

authors： Colle LM,Wise RA

更新日期：1988-09-06 00:00:00

abstract：:This study shows that the axons of some raphespinal sympathoinhibitory neurons projecting to the third thoracic spinal segment emit branches in the third-fourth cervical spinal segments of cats. This was demonstrated by using time-controlled collision of neuronal action potentials initiated by stimuli applied at these...

journal_title：Brain research

authors： Barman SM,Gebber GL

更新日期：1988-02-16 00:00:00

abstract：:parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellul...

journal_title：Brain research

authors： Oyama G,Yoshimi K,Natori S,Chikaoka Y,Ren YR,Funayama M,Shimo Y,Takahashi R,Nakazato T,Kitazawa S,Hattori N

更新日期：2010-09-17 00:00:00

abstract：:There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has neuroprotective effects. We examined the interaction of Neotrofin, a cognitive-enhancing and neuroprotective drug, with the heme oxygenase system. In adult rats, both a single administration or seven ...

journal_title：Brain research

authors： Wang X,Hauptmann N,Taylor E,Foreman M,Khawli LA,Maines MD

更新日期：2003-02-07 00:00:00

abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

journal_title：Brain research

authors： Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

更新日期：2002-10-04 00:00:00

abstract：:Transport of fragmented DNA in apical dendrites of the CA1 pyramidal neurons of gerbil hippocampus is observed in the apoptotic process following transient forebrain ischemia. The time-course of specific DNA fragmentation was examined after the ischemic insult by in situ nick-end-labeling method and fluorescence detec...

journal_title：Brain research

authors： Hara A,Niwa M,Iwai T,Nakashima M,Yano H,Uematsu T,Yoshimi N,Mori H

更新日期：1998-09-28 00:00:00

abstract：:Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...

journal_title：Brain research

authors： Henshel DS,Miller RF

更新日期：1992-03-20 00:00:00

abstract：:The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...

journal_title：Brain research

authors： Baranauskas G,Nistri A

更新日期：1996-11-04 00:00:00

abstract：:This study used microdialysis to measure changes in extracellular acetylcholine (ACh) content in the nucleus accumbens (NAC) of freely moving rats during acute and chronic morphine treatment, and following naloxone-precipitated withdrawal. Morphine injection (20 mg/kg, i.p.) caused a significant decrease in extracellu...

journal_title：Brain research

authors： Rada P,Pothos E,Mark GP,Hoebel BG

更新日期：1991-10-11 00:00:00

abstract：:The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...

journal_title：Brain research

authors： Hoshino K,Hicks TP,Meguro R,Hirano S,Kase M,Norita M

更新日期：1997-01-30 00:00:00

abstract：:Previous studies have indicated that central sensitization is a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation and astrocytes play an important role in the central sensitization. The current study investigated the role of amino ac...

journal_title：Brain research

authors： Wang J,Geng B,Shen HL,Xu X,Wang H,Wang CF,Ma JL,Wang ZP

更新日期：2012-04-17 00:00:00

abstract：:A carbohydrate epitope on adhesion proteins of the developing nervous system, and on myelin-associated glycoprotein, is recognized by the monoclonal antibody HNK-1. The HNK-1 epitope bearing proteins and the monoclonal antibody alter, in a dose-dependent manner, the interaction between neurons and neurite-promoting su...

journal_title：Brain research

authors： Riopelle RJ,McGarry RC,Roder JC

更新日期：1986-03-05 00:00:00

abstract：:Although extracellular matrix (ECM) glycoproteins play important roles in neural development, their levels are generally believed to decrease in the adult brain. Immunohistochemical analysis indicates that the anti-adhesive ECM glycoprotein SPARC/osteonectin, which contains a follistatin 'module,' is expressed in the ...

journal_title：Brain research

authors： Mendis DB,Malaval L,Brown IR

更新日期：1995-04-03 00:00:00

abstract：:Amyloid-beta protein (A beta) deposition in the cerebral vascular walls is one of the key features of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). A beta(1-40) carrying the 'Dutch' mutation (HCHWA-D A beta(1-40)) induces pronounced degeneration of cultured human brain p...

journal_title：Brain research

authors： Rensink AA,Verbeek MM,Otte-Höller I,ten Donkelaar HT,de Waal RM,Kremer B

更新日期：2002-10-11 00:00:00

abstract：:We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...

journal_title：Brain research

authors： Allen EE,Blakemore LJ,Trombley PQ,Gordon B

更新日期：1987-03-01 00:00:00

abstract：:The expression of the calcium-binding protein calretinin (CR) in the chick cochlear nucleus, nucleus magnocellularis (NM), was examined after unilateral cochlea removal in hatchlings and 3-week-old birds. Following survival times of 3, 6 or 12 h or 1, 3 or 7 days, CR mRNA was localized by in situ hybridization using a...

journal_title：Brain research

authors： Stack KE,Code RA

更新日期：2000-08-04 00:00:00

abstract：:Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...

journal_title：Brain research

authors： Kubota K,Seno T,Konishi Y

更新日期：2013-11-20 00:00:00

abstract：:Alzheimer׳s disease (AD) is a neurodegenerative disease with elusive pathogenesis, which accounts for most cases of dementia in the aged population. It has been reported that persistent inflammatory responses and excessive chemotaxis of microglia stimulated by beta-amyloid (Aβ) oligomers in the brain may accelerate th...

journal_title：Brain research

authors： Liu H,Wang J,Wang J,Wang P,Xue Y

更新日期：2015-08-27 00:00:00

abstract：:Nerve growth factor (NGF) transported intraaxonally from the adrenergic nerve terminals in the iris to the cell bodies in the superior cervical ganglion resulted in an increase in the activity of the enzyme ornithine decarboxylase in the ganglion. This occurred in both six-day-old and adult rats with the relative effe...

journal_title：Brain research

authors： Hendry IA,Bonyhady R

更新日期：1980-10-27 00:00:00

abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

journal_title：Brain research

authors： Read SJ,Parsons AA

更新日期：2000-07-07 00:00:00