Abstract：
:Exposure of organotypic dorsal root ganglion-spinal cord cultures to taxol, a potent microtubule promoting and stabilizing agent, results in an unusual abundance of microtubules in neurons, and the presence of microtubule-endoplasmic reticulum arrays in their perikarya and processes. Ordered concentric arrays of microtubules alternating with marcromolecular material are observed in dorsal root ganglion neurites. Short linear structures are discernible between some microtubules and the macromolecular material, as well as between microtubules and endoplasmic reticulum cisternae. Analyses of such unusual microtubule arrays in taxol-treated cultures may provide valuable insights into tubulin-related systems in neurons, as well as in other cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Masurovsky EB,Peterson ER,Crain SM,Horwitz SBdoi
10.1016/0006-8993(81)90017-2subject
Has Abstractpub_date
1981-08-03 00:00:00pages
392-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)90017-2journal_volume
217pub_type
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