Interfering with inhibition may improve motor function.


:Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is blocked pharmacologically. Thus, inhibitory processes influence normal motor development as well as recovery of function after neurological damage.


Brain Res


Brain research


Robinson GA,Goldberger ME




Has Abstract


1985-11-04 00:00:00














  • Perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) leads to changes in opioid-related behavioral patterns in rats.

    abstract::Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vela G,Fuentes JA,Bonnin A,Fernández-Ruiz J,Ruiz-Gayo M

    更新日期:1995-05-22 00:00:00

  • Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.

    abstract::Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cooper B,Werner HB,Flügge G

    更新日期:2008-03-04 00:00:00

  • Inhibitory effect of cyclic guanosine 3',5'-monophosphate (cGMP) on the afferent resting activity in the cephalopod statocyst.

    abstract::The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tu Y,Budelmann BU

    更新日期:2000-10-13 00:00:00

  • Acute low doses of melatonin restore full sexual activity in impotent male rats.

    abstract::Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Drago F,Busa' L

    更新日期:2000-09-29 00:00:00

  • Postsynaptic potentials evoked in spiny neostriatal projection neurons by stimulation of ipsilateral and contralateral neocortex.

    abstract::Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wilson CJ

    更新日期:1986-03-05 00:00:00

  • Post-ischemic hypothermia reduced IL-18 expression and suppressed microglial activation in the immature brain.

    abstract::Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left ca...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fukui O,Kinugasa Y,Fukuda A,Fukuda H,Tskitishvili E,Hayashi S,Song M,Kanagawa T,Hosono T,Shimoya K,Murata Y

    更新日期:2006-11-22 00:00:00

  • Glutathione metabolism in primary astrocyte cultures: flow cytometric evidence of heterogeneous distribution of GSH content.

    abstract::The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Devesa A,O'Connor JE,Garciá C,Puertes IR,Viña JR

    更新日期:1993-08-06 00:00:00

  • Enucleation demonstrates ocular dominance columns in Old World macaque but not in New World squirrel monkey visual cortex.

    abstract::The effect of monocular enucleation on basophilic and metabolic staining in primary (striate) visual cortex has been compared in Old and New World monkeys. Both species show a 30-40% shrinkage of neurons in the layers of dorsal lateral geniculate nucleus receiving axons from the enucleated eye. In striate cortex Old W...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hendrickson AE,Tigges M

    更新日期:1985-05-06 00:00:00

  • Stress and beta-carbolines decrease the density of low affinity GABA binding sites; an effect reversed by diazepam.

    abstract::Cerebral cortex membranes from rats habituated to manipulations preceding decapitation (habituated rats) had 40% higher GABA binding than membranes from naive animals. Diazepam (5 X 10(-6) M), added to membranes from naive rats, increased GABA binding to the level of habituated rats, but failed to induce any further i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Biggio G,Concas A,Serra M,Salis M,Corda MG,Nurchi V,Crisponi C,Gessa GL

    更新日期:1984-07-02 00:00:00

  • Determination of microdialysis extraction fraction of cocaine by the no net flux method under high, low, and zero steady-state cocaine concentrations in rats.

    abstract::The effect of different steady-state cocaine concentration maintenance on the microdialysis extraction fraction of cocaine (in situ recovery; Ed) in the medial prefrontal cortex (mPFC) was examined. Male, adult Sprague-Dawley rats anesthetized with chloral hydrate were used. All rats were randomly divided into three g...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pan WH,Lee JC

    更新日期:1995-07-24 00:00:00

  • The neuromechanism underlying verbal analogical reasoning of metaphorical relations: an event-related potentials study.

    abstract::Using event-related potentials (ERPs), this study investigated the neuromechanism underlying verbal analogical reasoning of two different metaphorical relations: attributive metaphor and relational metaphor. The analogical reasoning of attributive metaphor (AM-AR) involves a superficial similarity between analogues, w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhao M,Meng H,Xu Z,Du F,Liu T,Li Y,Chen F

    更新日期:2011-11-24 00:00:00

  • Sex differences in cell proliferation, cell death and defensive behavior following acute predator odor stress in adult rats.

    abstract::Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Falconer EM,Galea LA

    更新日期:2003-06-13 00:00:00

  • Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole-kindled rats.

    abstract::The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A

    更新日期:2010-06-25 00:00:00

  • Pineal nitric oxide synthase: characteristics, adrenergic regulation and function.

    abstract::Available studies indicate that the adrenergic stimulation of pineal cyclic GMP production involves stimulation of guanylyl cyclase activity by nitric oxide (NO) derived from arginine. This line of investigation was extended in the present study. Using a highly sensitive microassay, it was found that pineal NO synthas...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lin AM,Schaad NC,Schulz PE,Coon SL,Klein DC

    更新日期:1994-07-18 00:00:00

  • The effects of small doses of barbiturate on the activity of primate nociceptive tract cells.

    abstract::The activity of neurons identified as or similar to spinothalamic tract cells was compared in anesthetized, intact monkeys and in unanesthetized, decerebrate or spinalized animals. Background activity and responses to A- and C-fiber volleys were smaller in decerebrate than in the other preparations, suggesting the pre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hori Y,Lee KH,Chung JM,Endo K,Willis WD

    更新日期:1984-07-30 00:00:00

  • Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.

    abstract::Cholinergic systems modulate synaptic transmission across the neuraxis and play an important role in higher brain function including cognition, arousal and nociception. The anterior cingulate cortex (ACC) is a fundamental brain region for nociception and chronic pain, and receives cholinergic projections mainly from b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Koga K,Matsuzaki Y,Migita K,Shimoyama S,Eto F,Nakagawa T,Matsumoto T,Terada K,Mishima K,Furue H,Honda K

    更新日期:2019-02-01 00:00:00

  • Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice.

    abstract::We screened anti-Aβ1-42 antibodies from a human Alzheimer's disease (AD) specific single chain variable fragment (scFv) phage display library and assessed their effects in APP/PS1 transgenic mice. Reverse transcription-PCR was used to construct the scFv phage display library, and screening identified 11A5 as an anti-A...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wang J,Li N,Ma J,Gu Z,Yu L,Fu X,Liu X,Wang J

    更新日期:2016-03-15 00:00:00

  • Neuronal network properties of human teratocarcinoma cell line-derived neurons.

    abstract::Understanding the structural and functional development of neurons in networks has a high impact to estimate the potentials for restorative therapies. Neurons derived from the human NT2 cell line (hNT) formed networks with a clustered neuritic architecture in vitro, whereas primary dissociated embryonic rat cortical n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Görtz P,Fleischer W,Rosenbaum C,Otto F,Siebler M

    更新日期:2004-08-20 00:00:00

  • Tolerance of neonatal rat brain to acute hyperammonemia.

    abstract::The aim of the present work was to study the effects of hyperammonemia on brain energy metabolism in neonatal rats. Rats were rendered hyperammonemic by ammonium acetate administration. This decreased brain ATP concentrations but enhanced brain ammonia and lactate levels in both adult and neonatal rats. In adult rats,...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: García MV,López-Mediavilla C,Juanes de la Peña MC,Medina JM

    更新日期:2003-05-23 00:00:00

  • Ontogenesis of adenosine receptors in the central nervous system of the rat.

    abstract::The ontogeny of adenosine receptors was studied in rat brain and spinal cord using the specific ligand [3H]cyclohexyladenosine [( 3H]CHA). The [3H]CHA affinity constant (Kd) and the maximum receptor binding capacity (Bmax) were analyzed at all ages and in all CNS regions studied. Throughout development the Kd of [3H]C...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Geiger JD,LaBella FS,Nagy JI

    更新日期:1984-03-01 00:00:00

  • Attentional control of associative learning--a possible role of the central cholinergic system.

    abstract::How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Pauli WM,O'Reilly RC

    更新日期:2008-04-02 00:00:00

  • Acute ethanol/cannabinoid-induced ataxia and its antagonism by oral/systemic/intracerebellar A1 adenosine receptor antisense in mice.

    abstract::Previous reports from our laboratory have demonstrated that ethanol- and cannabinoid-induced ataxia is modulated by cerebellar adenosine A(1) receptor because intracerebellar (i.c.b.) adenosine A(1) agonists potentiated and A(1) antagonist attenuated ataxia by these psychoactive drugs. In this study, the novel approac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dar MS,Mustafa SJ

    更新日期:2002-12-06 00:00:00

  • Neuroprotective effects of N-stearoyltyrosine on transient global cerebral ischemia in gerbils.

    abstract::N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang YB,Kan MY,Yang ZH,Ding WL,Yi J,Chen HZ,Lu Y

    更新日期:2009-09-01 00:00:00

  • Retinal projection to the dorsal raphe nucleus in the Chilean degus (Octodon degus).

    abstract::A substantial projection from the retina to the dorsal raphe nucleus (DRN) has been demonstrated in the Chilean degus, a diurnal/crepuscular hystricomorph rodent. Following intraocular injection of cholera toxin subunit B (CTB), immunocytochemically labeled CTB-positive axons and terminals were observed in all major r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fite KV,Janusonis S

    更新日期:2001-03-23 00:00:00

  • Progesterone regulation of catecholamine secretion from chromaffin cells.

    abstract::Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Armstrong SM,Stuenkel EL

    更新日期:2005-05-10 00:00:00

  • Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism.

    abstract::Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled wi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rivier C,Vale W

    更新日期:1987-10-06 00:00:00

  • Age-related alterations of NMDA-receptor properties in the mouse forebrain: partial restoration by chronic phosphatidylserine treatment.

    abstract::The effect of aging on the properties of N-methyl-D-aspartate (NMDA) receptors in the forebrain of female NMRI mice was investigated using the antagonist [3H]MK-801 as radioligand. Compared to young (3 months) mice, aged (20 months) mice showed changes of the properties of the NMDA receptor at three different levels: ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cohen SA,Müller WE

    更新日期:1992-07-03 00:00:00

  • Habituation of exteroceptive suppression and of exteroceptive reflexes in man as influenced by voluntary contraction.

    abstract::Habituation kinetics were found to vary considerably in different polysynaptic pathways of the brain stem in man. The exteroceptive reflex of the digastric muscle habituates markedly, even for stimuli repeated at 1-min intervals. The second component of the blink reflex habituates for intervals below about 8 sec, but ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Desmedt JE,Godaux E

    更新日期:1976-04-16 00:00:00

  • Strain differences in distribution of phenylethanolamine N-methyltransferase activity from rat brain and adrenal gland.

    abstract::Phenylethanolamine N-methyltransferase (PNMT) activity was measured in adrenal glands and medulla oblongata from 4 inbred rat strains, Fischer 344, Buffalo, Lewis and Sprague-Dawley rats. Adrenal enzyme activity was markedly different among the strains with the highest in Fischer, followed by Sprague-Dawley, Lewis and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Park DH,Ehrlich M,Evinger MJ,Joh TH

    更新日期:1986-04-30 00:00:00

  • Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model.

    abstract::Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kobayashi H,Yokoyama M,Matsuoka Y,Omori M,Itano Y,Kaku R,Morita K,Ichikawa H

    更新日期:2008-04-24 00:00:00