Time course of changes in the concentrations of amino acids in the brain structures of pentylenetetrazole-kindled rats.


:The results showed that the development of seizures (pentylenetetrazole, PTZ-induced kindling; PTZ was administered to rats at a subconvulsive dose of 35mg/kg three times a week, i.p.) was accompanied by a progressive recruitment of limbic structures and a characteristic pattern of changes in the brain tissue concentration of examined amino acids (ex vivo measurements, 1.5h after the last dose of PTZ). The earliest and homogenous increase in the excitatory (glutamate and alanine) and inhibitory (GABA and taurine) amino acids was observed in the entorhinal cortex (at stages 1 and 2 according to Racine's scale), and this effect was maintained at the fifth stage of kindling (except for glutamate). At the fifth stage of kindling, glutamate was elevated in the amygdala, nucleus accumbens and piriform cortex, whereas alanine content was increased in the hippocampus, amygdala, striatum, nucleus accumbens and piriform cortex. In the case of GABA, a significant increase in the local concentration of this amino acid was found in rats with stage 1 and 2 seizures in the prefrontal and entorhinal cortices and a decrease was present in amygdala. Kindling raised the local level of taurine in the entorhinal cortex (stage 1 and 2 seizures), amygdala, nucleus accumbens and piriform cortex (stage 5 seizures). These data confirm the conclusion that separate seizure circuitries in the forebrain structures mutually interact to facilitate and/or inhibit one another. Overall, these data suggest that there is a shift in the balance between neurotransmitters toward increased production of excitatory amino acids.


Brain Res


Brain research


Maciejak P,Szyndler J,Turzyńska D,Sobolewska A,Bidziński A,Kołosowska K,Płaźnik A




Has Abstract


2010-06-25 00:00:00












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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Westergren I,Johansson BB

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  • The effect of the volatile anesthetic isoflurane on Ca(2+)-dependent glutamate release from rat cerebral cortex.

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    journal_title:Brain research

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    authors: Larsen M,Grøndahl TO,Haugstad TS,Langmoen IA

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  • Afferent projections related to attack sites in the pontine tegmentum.

    abstract::Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...

    journal_title:Brain research

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    authors: Smith DA,Flynn JP

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  • Light and electron microscopic analyses of intraspinal axon collaterals of sympathetic preganglionic neurons.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bogan N,Cabot JB

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  • The cholinergic influence on the function of the cat dorsal lateral geniculate nucleus (dLGN).

    abstract::The functional influence of the cholinergic input to cat dLGN has been examined by assessing the action of iontophoretically applied acetylcholine (ACh) on the visual responses of cells in layers A and A1. Iontophoretically applied pulses of ACh exerted a strong excitatory action on all 113 cells studied within these ...

    journal_title:Brain research

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    authors: Sillito AM,Kemp JA,Berardi N

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    journal_title:Brain research

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    authors: Schmidt-Kastner R,Aguirre-Chen C,Saul I,Yick L,Hamasaki D,Busto R,Ginsberg MD

    更新日期:2005-08-02 00:00:00

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    journal_title:Brain research

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    authors: Cohen J,Cheng MF

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    authors: Hübschle T,Küchenmeister I,Gerstberger R

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    authors: Engber TM,Boldry RC,Kuo S,Chase TN

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    journal_title:Brain research

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    authors: Aghajanian GK,Wang RY

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    journal_title:Brain research

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    pub_type: 杂志文章


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    authors: Sharma K,Mehra RD,Dhar P,Vij U

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Szallasi A,Nilsson S,Farkas-Szallasi T,Blumberg PM,Hökfelt T,Lundberg JM

    更新日期:1995-12-12 00:00:00

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    journal_title:Brain research

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sisken BF,Fowler I,Matson G,Thudium P,Barr E

    更新日期:1985-04-01 00:00:00

  • Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by beta antagonists.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Morton KD,Johnson MD,Van de Kar LD

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Soldo BL,Moises HC

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Le Gal La Salle G,Naquet R

    更新日期:1990-06-04 00:00:00

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Borlongan CV,Lind JG,Dillon-Carter O,Yu G,Hadman M,Cheng C,Carroll J,Hess DC

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Stanton PK,Sarvey JM

    更新日期:1985-12-30 00:00:00