Abstract:
:We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, M(4) selective). Our results revealed a significant decrease in muscarinic M(4) receptor binding in the dentate gyrus and CA4 regions of brain sections from Alzheimer's patients compared to controls. No changes in the density of M(1) or M(2) receptor binding were observed. Our findings suggest that, relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease (AD).
journal_name
Brain Resjournal_title
Brain researchauthors
Mulugeta E,Karlsson E,Islam A,Kalaria R,Mangat H,Winblad B,Adem Adoi
10.1016/s0006-8993(02)03542-4subject
Has Abstractpub_date
2003-01-17 00:00:00pages
259-62issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302035424journal_volume
960pub_type
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