Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients.

Abstract:

:We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, M(4) selective). Our results revealed a significant decrease in muscarinic M(4) receptor binding in the dentate gyrus and CA4 regions of brain sections from Alzheimer's patients compared to controls. No changes in the density of M(1) or M(2) receptor binding were observed. Our findings suggest that, relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease (AD).

journal_name

Brain Res

journal_title

Brain research

authors

Mulugeta E,Karlsson E,Islam A,Kalaria R,Mangat H,Winblad B,Adem A

doi

10.1016/s0006-8993(02)03542-4

subject

Has Abstract

pub_date

2003-01-17 00:00:00

pages

259-62

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006899302035424

journal_volume

960

pub_type

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