Abstract:
:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods could restore cognitive impairment induced by prenatal maternal seizure is unknown. Adult female Sprague-Dawley rats were randomly separated into two groups and were injected intraperitoneally either saline or pentylenetetrazol (PTZ) for 30 days. Then the fully kindled rats and control animals were allowed to mate. PTZ administration was continued until delivery, while the control group received saline at the same time. After weaning at postnatal day 22, one-half of the male offspring in the control and in the prenatal maternal group were given the environmental enrichment treatment through all the experiments until they were tested. Morris water maze testing was performed at 8 weeks of age. Western blot and synaptic ultrastructure analysis were then performed. We found that EE treatment reversed spatial learning deficits induced by prenatal maternal seizure. An EE also reversed the changes in synaptic ultrastructure following prenatal maternal seizure. In addition, prenatal maternal seizure significantly decreased phosphorylation states of cAMP response element binding (CREB) in the hippocampus, whereas EE reversed this reduced expression. These findings suggest that EE treatment on early postnatal periods could be a potential therapy for improving cognitive deficits induced by prenatal maternal seizure.
journal_name
Brain Resjournal_title
Brain researchauthors
Xie T,Wang WP,Jia LJ,Mao ZF,Qu ZZ,Luan SQ,Kan MCdoi
10.1016/j.brainres.2012.06.034subject
Has Abstractpub_date
2012-08-27 00:00:00pages
80-8eissn
0006-8993issn
1872-6240pii
S0006-8993(12)01109-2journal_volume
1470pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::This report deals with the effect of substance P (SP) and capsaicin on blood pressure and heart rate after administration into different sites of the nucleus tractus solitarii (NTS) of urethane-anesthetized rats. Microinjection of SP at 6 different coordinates throughout the NTS showed 3 sites where SP administration ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90938-3
更新日期:1987-10-06 00:00:00
abstract::uinea pig antiserum specific to the purified bovine choline acetyltransferase was used to demonstrate the localization of this enzyme in rabbit forebrain by the peroxidase-antiperoxidase immunohistochemical method. Choline acetyltransferase was localized in olfactory bulb, olfactory tract, olfactory tubercle, piriform...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90196-2
更新日期:1982-03-04 00:00:00
abstract::We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91089-b
更新日期:1993-07-23 00:00:00
abstract::The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90982-h
更新日期:1990-06-04 00:00:00
abstract::Calretinin-immunoreactive structures in the anterior olfactory nucleus of the rat were studied using a polyclonal antibody, which does not cross-react with the highly homologous calcium-binding protein calbindin-D28k, and the avidin-biotin-peroxidase technique. Calretinin-immunopositive neurons were found in all regio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00023-7
更新日期:1998-04-06 00:00:00
abstract::Axonal transport of fluorescent dyes applied to the cut distal ends of rat L4 dorsal and ventral spinal roots was studied in order to characterize the population of dorsal root ganglion (DRG) neurons emitting axons entering the ventral root. Ca. 9% of DRG neurons, principally of small or medium size, can be labeled fr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90053-9
更新日期:1987-02-03 00:00:00
abstract::The projections of serotonin-containing neurons of the midbrain raphe nuclei (nucleus raphe dorsalis, nucleus centralis superior) are studied by analysis of axonal transport of labeled amino acids. These results are correlated with regional alterations of serotonin content following midbrain raphe lesions which produc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90144-x
更新日期:1976-05-14 00:00:00
abstract::Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90834-3
更新日期:1975-01-17 00:00:00
abstract::This study shows that in the choroid plexus of Rana esculenta particulate guanylate cyclase (GC) is appreciably stimulated by porcine brain natriuretic peptide (BNP). Ultracytochemical tests for GC show that BNP notably increases the enzymatic reaction product along the apical surfaces of the epithelial cells. It can ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01178-1
更新日期:1995-12-24 00:00:00
abstract::In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.051
更新日期:2007-07-09 00:00:00
abstract::An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.092
更新日期:2009-12-01 00:00:00
abstract::Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91398-4
更新日期:1988-02-16 00:00:00
abstract::Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.09.035
更新日期:2004-12-17 00:00:00
abstract::Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, likely associated with dysregulation of oxidation of catechols, such as dopamine (DA) and 6-hydroxydopamine (6-OHDA), and resulting in oxidative stress. The involvement of cyclooxygenase-2 (COX-2) in pathogenesis of Parkinson's disease...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.105
更新日期:2006-06-06 00:00:00
abstract::Increased alcohol consumption and heightened aggression have been linked to social isolation. Furthermore, animals treated with alcohol following social separation showed higher aggression together with lower serotonin transmission. Although reduced serotonin transmission in the brain may be related to alcohol-induced...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.02.007
更新日期:2017-05-01 00:00:00
abstract::The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90148-8
更新日期:1985-01-01 00:00:00
abstract::Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90108-7
更新日期:1978-12-22 00:00:00
abstract::Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.017
更新日期:2007-04-13 00:00:00
abstract::Male laboratory rats were raised in two colonies, each of 27 rats, and then given intraventricular injections of the norepinephrine neurotoxin 6-hydroxydopamine (6-OHDA) or the serotonin neurotoxin 5,6-dihydroxytryptamine (5,6-DHT) or saline. They were then returned to their enclosure and behavior during the next 50 d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90688-0
更新日期:1976-02-13 00:00:00
abstract::Sex differences in cocaine's mechanisms of action and behavioral effects have been widely reported. However, little is known about how sex influences intracellular signaling cascades involved with drug-environment associations. We investigated whether ERK/CREB intracellular responses in the mesocorticolimbic circuitry...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.04.060
更新日期:2013-07-03 00:00:00
abstract::The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90007-5
更新日期:1977-07-01 00:00:00
abstract::Depolarizing actions of 4 conformationally restricted L-glutamate analogues, (2S,3S,4S) isomer (L-CCG-I), (2S,3R,4R) isomer (L-CCG-II), (2S,3S,4R) isomer (L-CCG-III) and (2S,3R,4S) isomer (L-CCG-IV) of L-alpha-(carboxycyclopropyl)-glycine (L-CCG), were investigated in the isolated rat spinal cord by extracellular reco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90207-2
更新日期:1989-02-20 00:00:00
abstract::We have studied in adult rats bearing a unilateral nigral lesion the effect of nigral grafts into the striatum on behavioral supersensitivity induced by chronic treatment of L-DOPA (100 mg/kg i.p.) plus benserazide (50 mg/kg i.p.). Repeated administration of L-DOPA increases contraversive circling. In rats without gra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91215-3
更新日期:1990-01-01 00:00:00
abstract::Intracellular recordings were performed in vitro from both pars compacta and pars reticulata neurones of the substantia nigra, and their postsynaptic responses to electrical stimulation within the nucleus were analysed. Intracellular staining by biocytin was used to reveal the morphology and location of the recorded n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91292-0
更新日期:1994-10-17 00:00:00
abstract::Transplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved functional outcome. Mechanisms suggested to account for this functional improvement include axonal regeneration, remyelination and neuroprotection. OECs transplanted into transected peripheral nerve have been shown to mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.09.089
更新日期:2006-12-13 00:00:00
abstract::Synapses onto dendritic spines in the lateral amygdala formed by afferents from the auditory thalamus represent a site of plasticity in Pavlovian fear conditioning. Previous work has demonstrated that thalamic afferents synapse onto LA spines expressing glutamate receptor (GluR) subunits, but the GluR subunit distribu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.045
更新日期:2007-02-23 00:00:00
abstract::Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01064-1
更新日期:1999-03-06 00:00:00
abstract::Short-latency afferent inhibition (SAI) and long-latency afferent inhibition (LAI) are well-known transcranial magnetic stimulation (TMS) paradigms used to probe the sensorimotor system. To date, there is a paucity of research examining the reliability of these neurophysiological measures. This information is required...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.146394
更新日期:2019-11-15 00:00:00
abstract::The specific binding of [3H]kainic acid to hippocampal membranes was examined autoradiographically in rats kindled by tetanic stimulation of the amygdala or angular bundle. One day after the last of 3 class 4-5 kindled seizures, the specific binding of [3H]kainic acid in stratum lucidum of area CA3 was 47-61% less tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90274-9
更新日期:1984-12-03 00:00:00
abstract::A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.049
更新日期:2010-04-22 00:00:00