Abstract:
:We have studied in adult rats bearing a unilateral nigral lesion the effect of nigral grafts into the striatum on behavioral supersensitivity induced by chronic treatment of L-DOPA (100 mg/kg i.p.) plus benserazide (50 mg/kg i.p.). Repeated administration of L-DOPA increases contraversive circling. In rats without graft the contraversive circling was significantly increased after 8 and 14 daily injections of L-DOPA. On the other hand, the animals with transplants showed no such increase. Behavioral supersensitivity induced by repeated treatment of L-DOPA is often correlated with dyskinesia observed in the Parkinsonian patients. This suggests that the graft might be able to prevent this secondary effect.
journal_name
Brain Resjournal_title
Brain researchauthors
Gaudin DP,Rioux L,Bédard PJdoi
10.1016/0006-8993(90)91215-3subject
Has Abstractpub_date
1990-01-01 00:00:00pages
166-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)91215-3journal_volume
506pub_type
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