Abstract：
:While much has been elucidated about the hypothalamic controls of energy balance, the epidemic of obesity continues to escalate. Recent work has suggested that extra-hypothalamic central nervous system structures may play a previously un-appreciated role in the control of ingestive behavior and body weight regulation. Because animals can and do learn about food and food-related stimuli, as well as the consequences of eating, we and others have sought to understand the cognitive process that underlies that learning. Additionally, we have begun to investigate the neuro-anatomical bases for complex learning about food and food cues. Here we review some evidence for learning about food as well as evidence that the hippocampus may play a critical role in the brain's ability to regulate body weight through such learning processes.
journal_name
Brain Resjournal_title
Brain researchauthors
Benoit SC,Davis JF,Davidson TLdoi
10.1016/j.brainres.2010.06.009subject
Has Abstractpub_date
2010-09-02 00:00:00pages
71-6eissn
0006-8993issn
1872-6240pii
S0006-8993(10)01344-2journal_volume
1350pub_type
杂志文章,评审相关文献
BRAIN RESEARCH文献大全abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.084
更新日期：2004-05-08 00:00:00
abstract：:Excitatory transmission along the perforant path from the entorhinal cortex to the granule cells of the dentate gyrus was evaluated two days after 10 min of transient cerebral ischemia in the rat. The amplitude of the population spike, and the amplitude and the initial slope of the population excitatory postsynaptic p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91446-7
更新日期：1989-12-29 00:00:00
abstract：:Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used to investigate the actions of drugs of abuse. However, few studies have examined both paradigms in the same group of animals. We were interested in developing a combined protocol which successfully induced both conditio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.054
更新日期：2008-06-05 00:00:00
abstract：:Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.008
更新日期：2006-06-13 00:00:00
abstract：:To date, few treatment strategies applying cellular transplantation to the chronically injured spinal cord have yielded significant functional improvement in animal experiments. Here we report that significant improvement of locomotor function was achieved in rats with chronic spinal cord injury (SCI) by the applicati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.054
更新日期：2012-05-25 00:00:00
abstract：:The purpose of the present study was to investigate the possible involvement of hippocampal NMDA (N-methyl-d-aspartate) receptors in spatial memory in rats by means of intrahippocampal injection of an NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid). In Expt. 1, spontaneous motor activity (locomotor activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01256-0
更新日期：1998-01-19 00:00:00
abstract：:We investigated the effects of a novel Na(+)/H(+) exchanger-1 (NHE-1) inhibitor KR-33028 on glutamate excitotoxicity in cultured neuron cells in vitro and cerebral infarct in vivo by comparing its potency with that of zoniporide, a well-known, highly potent NHE-1 inhibitor. KR-33028 inhibited NHE-1 activation in a con...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.061
更新日期：2009-01-12 00:00:00
abstract：:There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91574-5
更新日期：1987-12-08 00:00:00
abstract：:We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02293-9
更新日期：2000-06-09 00:00:00
abstract：:Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90693-h
更新日期：1993-02-05 00:00:00
abstract：:The effect of indole-3-acetaldehyde, 5-hydroxyindole-3-acetaldehyde, disulfiram, diethyldithiocarbamate, coprine, and 1-amino-cyclopropanol on tryptophan hydroxylase activity was studied in vitro using high performance liquid chromatography with electro-chemical detection. With the analytical method developed, 5-hydro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90726-8
更新日期：1987-04-21 00:00:00
abstract：:Three types of hyperpolarization in response to applied acetylcholine (ACh) were observed in 4 identified neurones (RP1, RP2, RP3 and RP4) in the right parietal ganglion of the African giant snail, Achatina fulica Férussac. In order to clarify the ionic mechanisms of these responses, the neurones were voltage-clamped ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90416-6
更新日期：1986-05-28 00:00:00
abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91627-d
更新日期：1991-01-25 00:00:00
abstract：:The two neurosteroids 3alpha-hydroxy-5alpha-pregnane-20-one (allopregnanolone; AlloP) and pregnenolone sulfate (PregS) affect neuronal GABA(A) receptors differently. While AlloP mainly potentiates the currents through GABA(A) receptors, PregS reduces such currents. The present study aimed at clarifying the interaction...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.020
更新日期：2005-02-01 00:00:00
abstract：:The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91476-w
更新日期：1990-07-09 00:00:00
abstract：:The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.03.010
更新日期：2016-07-01 00:00:00
abstract：:The medial nucleus of the amygdala, bed nucleus of the stria terminalis, and medial preoptic area appear to mediate steroidal regulation of mating behavior in male rodents. The mechanism of action has not been determined. One way testosterone could enhance neuronal function is by increasing neurotransmitter levels, th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91077-r
更新日期：1992-09-11 00:00:00
abstract：:The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N2O). This study was conducted to determine whether this behavioral effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N2O-induced behavior in the light/dark exploration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.015
更新日期：2005-03-15 00:00:00
abstract：:We used rabbit antisera against manganese (Mn)-superoxide dismutase for immunohistochemical studies of localization in the rat neostriatum. Immunostaining was intense in large-sized neurons and several medium-sized neurons, but it was moderate to weak in other cells. Double immunostaining with monoclonal antibody to c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90618-6
更新日期：1991-05-17 00:00:00
abstract：:The involvement of terminal sprouts in neurotransmitter release by in vivo botulinum type-A toxin poisoned motor endings was investigated 15 to 40 days after a single injection of the toxin onto the levator auris longus muscle of the mouse. Enhanced quantal acetylcholine release was induced by alpha-latrotoxin or La3+...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00475-2
更新日期：1998-06-29 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.034
更新日期：2016-10-01 00:00:00
abstract：:The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04149-5
更新日期：2003-03-21 00:00:00
abstract：:Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to local injection of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90500-1
更新日期：1985-06-03 00:00:00
abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90564-8
更新日期：1980-04-21 00:00:00
abstract：:Previous data suggest a relationship between the loss of response to levodopa in Parkinson's disease (PD) patients with the co-occurrence of dementia, but the role of alterations in the dopamine system has not been explored. We measured the extent of striatal DA loss and changes in striatal DA D(2) and D(3) receptors ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03396-6
更新日期：2002-11-15 00:00:00
abstract：:The hippocampus is involved in key neuronal circuits that underlie cognition, memory, and anxiety, and it is increasingly recognized as a vulnerable structure that contributes to the pathogenesis of HIV-associated neurocognitive disorder (HAND). However, the mechanisms responsible for hippocampal dysfunction in neuroH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146431
更新日期：2019-12-01 00:00:00
abstract：:The genomic response following brain ischemia is very complex and involves activation of both protective and detrimental signaling pathways. Immediate early genes (IEGs) represent the first wave of gene expression following ischemia and are induced in extensive regions of the ischemic brain including cerebral cortex a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.005
更新日期：2007-06-02 00:00:00
abstract：:Corticosteroids exert important effects on brain function via glucocorticoid (GRs) and mineralocorticoid receptors (MRs) by inducing receptor translocation to the nucleus, where the receptor-ligand complexes modulate transcription of target genes. Based on studies describing uneven receptor expression patterns, region...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.048
更新日期：2009-01-16 00:00:00
abstract：:The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00423-n
更新日期：1995-07-17 00:00:00
abstract：:Nitric oxide (NO) is a neuronal messenger that it is thought to be involved in the nociceptive transmission modulation. The activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) was shown to be identical to NOS activity in the brain. Since the periaqueductal gray matter (PAG) plays an important ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00255-8
更新日期：1998-05-18 00:00:00
