当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium.

Survival and mitogenesis of neuroepithelial cells are influenced by noradrenergic but not cholinergic innervation in cultured embryonic rat neopallium.

Abstract：

:alpha-Adrenoreceptors are present in the ventricular (VZ) and subventricular (SVZ) zones of the mammalian embryonic forebrain, and contribute towards cell cycle controls in the germinal neuroepithelium [Pabbathi et al., Brain Res. 760 (1997) 22-33.]. Since noradrenaline-containing fibres from the locus coeruleus (LC) and other brainstem nuclei innervate many parts of the CNS from an early stage of embryogenesis, we have used heterochronic cocultures to investigate whether noradrenergic innervation may be the source of trophic support. Dorsal neopallium from E13 rat embryo was cultured in proximity to E15 rostral pons (RP), enabling rapid innervation of the neuroepithelium by differentiated noradrenergic neurons of the LC. The projection of interconnecting fibres into germinal areas of the cortex was established in vitro by retrograde tracing and dopamine beta-hydroxylase (DBH) immunocytochemistry. When functional innervation was prevented by transection of axons connecting the explants, the number of apoptotic (TUNEL-positive) cells in the neopallium was increased. Bromodeoxyuridine (BrdU) double-labelling confirmed that germinal cells were amongst those which underwent apoptosis. When cortical explants were innervated by a source of non-monoaminergic (cholinergic) axons from the E18 basal forebrain diagonal band/septum complex (DS), numbers of apoptotic cells were comparable to those in non-innervated cultures. alpha1 and alpha2 adrenoreceptor antagonists included in the medium of cortical cocultures innervated by noradrenergic axons reversed the survival-promoting effect of innervation. Blockade of alpha1 but not of alpha2 receptors also reduced the numbers of S-phase nuclei in the cortex. The results provide evidence that local delivery of neurotransmitter from embryonic noradrenergic axons terminating in the neocortex can regulate survival and proliferation of neuroepithelial cells.

journal_name

Brain Res

journal_title

Brain research

authors

Popovik E,Haynes LW

doi

10.1016/s0006-8993(99)02242-8

subject

Has Abstract

pub_date

2000-01-24 00:00:00

pages

227-35

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(99)02242-8

journal_volume

853

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Onset and dynamic expression of S100 proteins in the olfactory organ and the lateral line system in zebrafish development.

    abstract：:In the zebrafish olfactory epithelium, three morphologically distinct olfactory neurons express different marker proteins. We utilize this feature to access developmental dynamics of one of the neuron types, the crypt cells, to determine whether they are differentiated at a stage similar to other olfactory neurons. Im...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2011.01.087

    authors： Sandulescu CM,Teow RY,Hale ME,Zhang C

    更新日期：2011-04-06 00:00:00

  • Intracerebroventricular saccharide infusions inhibit thirst induced by systemic hypertonicity.

    abstract：:The effect of intracerebroventricular (i.c.v.) infusion of various iso- and hypertonic saccharide solutions on water intake stimulated by intracarotid (i.c.) infusion of hypertonic NaCl was studied in sheep. Without an i.c.v. infusion, water intake during a 10-min period following an i.c. infusion of 4 M NaCl (1.4 ml/...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)91006-8

    authors： Park R,Denton DA,McKinley MJ,Pennington G,Weisinger RS

    更新日期：1989-07-24 00:00:00

  • Effects of concurrent manipulations of cholinergic and noradrenergic function on learning and retention in mice.

    abstract：:Interactions between the neuromodulators acetylcholine and norepinephrine (NE) have been reported in both developmental neural plasticity and learning and memory. In a test of the generality of this phenomenon, we assessed the amnestic effects of the muscarinic antagonist scopolamine in normal and NE-depleted mice. Pr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(89)91391-7

    authors： Decker MW,McGaugh JL

    更新日期：1989-01-16 00:00:00

  • Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat.

    abstract：:The median preoptic nucleus (MnPN) of the hypothalamus contains sleep-active neurons including sleep-active GABAergic neurons and is involved in the regulation of nonREM/REM sleep. The hypocretinergic (HCRT) neurons of the perifornical-lateral hypothalamic area (PF-LHA) and serotonergic (5-HT) neurons of the dorsal ra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.07.115

    authors： Kumar S,Szymusiak R,Bashir T,Suntsova N,Rai S,McGinty D,Alam MN

    更新日期：2008-10-09 00:00:00

  • Behavioral sensitization to cocaine: modulation by the cyclic AMP system in the nucleus accumbens.

    abstract：:We have previously observed that chronic cocaine administration increases levels of adenylyl cyclase and cAMP-dependent protein kinase (PKA) in the nucleus accumbens (NAc). In the present work we directly examined the involvement of the cAMP system at the level of the NAc in cocaine-induced locomotor activity and sens...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)00030-t

    authors： Miserendino MJ,Nestler EJ

    更新日期：1995-03-20 00:00:00

  • Cycloheximide activation of the lordotic response in low-dose, estrogen-treated ovariectomized rats: evidence for modulating inhibitory influences of the limbic system on sexual behavior.

    abstract：:This study tested the effect on intracranially injected cycloheximide (CHX), an inhibitor of protein synthesis, on facilitation of sexual receptivity in ovariectomized rats. The rats received 0.5 microgram estradiol benzoate (EB), s.c. once daily on days 8 through 12 after ovariectomy (OVX). Either CHX (in 0.5 microli...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(81)91050-7

    authors： Renner KJ,Bast JD,Purcell ES,Quadagno DM

    更新日期：1981-10-19 00:00:00

  • Exercise increases metabolic capacity in the motor cortex and striatum, but not in the hippocampus.

    abstract：:Acute bouts of exercise have been shown to produce transient increases in regional cerebral glucose utilization, oxygen uptake, and cerebral blood flow in motor cortex, striatum, and hippocampus. The purpose of this study was to determine whether or not chronic exercise will cause long-term metabolic plasticity in bra...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(00)03200-5

    authors： McCloskey DP,Adamo DS,Anderson BJ

    更新日期：2001-02-09 00:00:00

  • Separately developing axonal uptake of 5-hydroxytryptamine and norepinephrine in the fetal ileum of the rabbit.

    abstract：:Uptake of 5-hydroxytryptamine (5-HT) by adult and fetal rabbit's ileum was studied. The adult myenteric plexus accumulated tritium when incubated with tritiated 5-HT. However, in addition to labeled 5-HT, tritiated 5-hydroxyindole acetic acid and, when monoamine oxidase (MAO) was inhibited, 5-HT-o-glucuronide were fou...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90360-7

    authors： Rothman TP,Ross LL,Gershon MD

    更新日期：1976-10-22 00:00:00

  • Comparison analysis of distributions of tyrosine hydroxylase, calmodulin and calcium/calmodulin-dependent protein kinase II in a triple stained slice of rat brain.

    abstract：:The immunohistochemical distributions of tyrosine hydroxylase (TH), calmodulin (CaM) and calcium/CaM-dependent protein kinase II (CaMKII) in the rat forebrain were compared quantitatively to confirm our previous finding that TH activity and dopamine synthesis in the brain are regulated by a calcium/CaM-dependent syste...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)02271-0

    authors： Sutoo D,Akiyama K,Yabe K

    更新日期：2002-04-12 00:00:00

  • Fetally-induced noradrenergic hyperinnervation of cerebral cortex results in persistent down-regulation of beta-receptors.

    abstract：:Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(82)90195-x

    authors： Beaulieu M,Coyle JT

    更新日期：1982-08-01 00:00:00

  • Mechanisms whereby nerve growth factor increases diacylglycerol levels in differentiating PC12 cells.

    abstract：:We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)01280-3

    authors： Li J,Wurtman RJ

    更新日期：1999-02-13 00:00:00

  • A comparison of human tactile stimulus velocity discrimination with the ability of S-I cortical neurons in awake rhesus monkeys to signal the same velocity differences before and after non-anesthetic doses of pentobarbital.

    abstract：:Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(80)90746-5

    authors： Collins JG,Roppolo JR

    更新日期：1980-10-06 00:00:00

  • Stress and electroconvulsive seizure differentially alter GPR56 expression in the adult rat brain.

    abstract：:GPR56, a member of the G-protein-coupled receptor family, plays a role in the formation of the frontal and parietal brain lobes and cortical lamination in the embryonic stage. A recent report indicated the existence of GPR56 transcripts in the subventricular zone (SVZ) and hippocampal subgranular zone (SGZ) of the adu...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.09.020

    authors： Suzuki G,Kanda Y,Nibuya M,Hiramoto T,Tanaka T,Shimizu K,Watanabe Y,Nomura S

    更新日期：2007-12-05 00:00:00

  • Maternal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats.

    abstract：:Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separat...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2004.04.003

    authors： Marin MT,Planeta CS

    更新日期：2004-07-02 00:00:00

  • Synaptic glomeruli in the nucleus submedius of the rat thalamus.

    abstract：:Synaptic glomeruli in the nucleus submedius of the rat are described and the source of some of the component terminals identified. The glomeruli consist of large terminals with round synaptic vesicles establishing Gray type I contacts with dendrites and surrounded by layers of astrocyte derived membranes. The astrocyt...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90215-0

    authors： Ma W,Ohara PT

    更新日期：1987-07-14 00:00:00

  • Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.

    abstract：:Recent researches suggest that autophagic degradation declines with age, and this leads to an accumulation of damage that contributes to age-related cellular dysfunction. Nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) shows therapeutic potential for cerebral ischemia in young-adult animals. This study inve...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2019.146391

    authors： Wang P,Lu Y,Han D,Wang P,Ren L,Bi J,Liang J

    更新日期：2019-11-15 00:00:00

  • The alpha 1-noradrenergic antagonist prazosin decreases the concentration of estrogen receptors in female rat hypothalamus.

    abstract：:A series of experiments was performed to determine the effects of the alpha 1-noradrenergic antagonist, prazosin, on the concentration of estrogen receptors in female rat brain and pituitary gland. Prazosin caused a dose-dependent decrease in the concentration of cytosol estrogen receptors in mediobasal hypothalamus w...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)91353-9

    authors： Blaustein JD

    更新日期：1987-02-24 00:00:00

  • Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development.

    abstract：:A hundred years after Lhx2 ortholog apterous was identified as a critical regulator of wing development in Drosophila, LIM-HD gene family members have proved to be versatile and powerful components of the molecular machinery that executes the blueprint of embryogenesis across vertebrate and invertebrate species. Here,...

    journal_title：Brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.brainres.2018.02.046

    authors： Chou SJ,Tole S

    更新日期：2019-02-15 00:00:00

  • Physiological and morphological identification of a nonpyramidal hippocampal cell type.

    abstract：:In intracellular recordings from the CA1 region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potential...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(78)90991-5

    authors： Schwartzkroin PA,Mathers LH

    更新日期：1978-11-17 00:00:00

  • Central amygdaloid nucleus lesion attenuates exaggerated hemodynamic responses to noise stress in the spontaneously hypertensive rat.

    abstract：:The regional hemodynamic basis of the cardiovascular response to acute noise stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats and the role of the central amygdaloid nucleus in mediating this response was investigated. Using the pulsed Doppler flow probe technique it was determined that in respons...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)91257-5

    authors： Galeno TM,Van Hoesen GW,Brody MJ

    更新日期：1984-01-23 00:00:00

  • A translationally relevant thromboembolic stroke model for the study of secondary hemorrhage after thrombolysis in rats.

    abstract：:Secondary hemorrhage after thrombolysis in ischemic stroke is an important complication, which has been difficult to study in preclinical disease models. We have established and characterized a model of thromboembolic middle cerebral artery occlusion in rats. Advantages of this model include a very low rate of spontan...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.10.067

    authors： Sun L,Zhou W,Heiland S,Marti HH,Veltkamp R

    更新日期：2011-01-12 00:00:00

  • Histamine regulates food intake through modulating noradrenaline release in the para-ventricular nucleus.

    abstract：:Histamine is one of the neurotransmitters suppressing appetite, but the interactions of histaminergic neurons with other neurons in satiety centers have not been clarified. Noradrenaline in the para-ventricular nucleus (PVN) has been shown to stimulate feeding. This study was designed to determine whether histamine mo...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01339-6

    authors： Kurose Y,Terashima Y

    更新日期：1999-05-15 00:00:00

  • Studies on the encephalitogenic effects of purified preparations of human and bovine oligodendrocytes.

    abstract：:Bulk-isolated human and bovine oligodendroglia, practically free from myelin, have been used in attempts to elicit an autoimmune response which has been compared with acute experimental allergic encephalomyelitis (EAE). For these experiments, a total of 20 Hartley guinea pigs, 33 Lewis rats and 16 rabbits have been st...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(77)90906-4

    authors： Raine CS,Wiśniewski HM,Iqbal K,Grundkeiqbal I,Norton WT

    更新日期：1977-01-21 00:00:00

  • Studies on the relationship of binding affinity to psychoactive and anticholingergic potency of a group of psychotomimetic glycolates.

    abstract：:A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(77)90889-7

    authors： Baumgold J,Abood LG,Aronstam R

    更新日期：1977-03-25 00:00:00

  • Transient receptor potential vanilloid 1-6 (Trpv1-6) gene expression in the mouse brain during estrous cycle.

    abstract：:In recent years estradiol has emerged as a potential regulator of transient receptor potential vanilloid (TRPV) cationic channels in the peripheral tissues and sensory neurons, however, its analogous role in the CNS is poorly understood. TRPV channels modulate Ca2+ signalling, neurotransmission and behaviour, and expr...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2018.09.005

    authors： Kumar S,Singh O,Singh U,Goswami C,Singru PS

    更新日期：2018-12-15 00:00:00

  • Dopamine D2 receptor supersensitivity in the hypothalamus of olfactory bulbectomized mice.

    abstract：:Olfactory bulbectomy (OBX) in rodents induces neurochemical and behavioral changes similar to those observed in individuals with depressive disorders. Our previous study suggested that OBX alters dopaminergic function in the striatum of mice; however, the effects on dopaminergic function in the hypothalamus is unknown...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2020.147015

    authors： Takahashi K,Nakagawasai O,Nakajima T,Okubo M,Nishimura Y,Sakuma W,Yamagata R,Nemoto W,Miyagawa K,Kurokawa K,Mochida-Saito A,Tsuji M,Takeda H,Tadano T,Tan-No K

    更新日期：2020-11-01 00:00:00

  • High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.

    abstract：:In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(83)90018-4

    authors： Kristt DA,Kasper EK

    更新日期：1983-06-01 00:00:00

  • Methionine-free brain-derived neurotrophic factor in wobbler mouse motor neuron disease: dose-related effects and comparison with the methionyl form.

    abstract：:We compared the clinical and pharmacodynamic effects of N-terminal methionine brain-derived neurotrophic factor (met-BDNF) and endogenous met-free BDNF in wobbler mouse motor neuron disease (MND). Met- or met-free BDNF at 5 or 20 mg/kg was subcutaneously injected daily, six times/week for 4 weeks. At 20 mg/kg, grip st...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(02)02881-0

    authors： Ishiyama T,Ogo H,Wong V,Klinkosz B,Noguchi H,Nakayama C,Mitsumoto H

    更新日期：2002-07-19 00:00:00

  • Diet and the epigenetic (re)programming of phenotypic differences in behavior.

    abstract：:Phenotypic diversity is shaped by both genetic and epigenetic mechanisms that program tissue specific patterns of gene expression. Cells, including neurons, undergo massive epigenetic reprogramming during development through modifications to chromatin structure, and by covalent modifications of the DNA through methyla...

    journal_title：Brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.brainres.2008.07.074

    authors： McGowan PO,Meaney MJ,Szyf M

    更新日期：2008-10-27 00:00:00

  • Evidence that beta-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA.

    abstract：:Evidence from a number of sources indicates that the major site of pro-opiomelanocortin (POMC)-producing cells in the CNS is the arcuate nucleus of the hypothalamus. Using immunocytochemical techniques, a second, smaller group of POMC cells has been detected in the nucleus tractus solitarius (NTS) area of the caudal m...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91007-2

    authors： Bronstein DM,Schafer MK,Watson SJ,Akil H

    更新日期：1992-08-07 00:00:00