Abstract：
:Interactions between the neuromodulators acetylcholine and norepinephrine (NE) have been reported in both developmental neural plasticity and learning and memory. In a test of the generality of this phenomenon, we assessed the amnestic effects of the muscarinic antagonist scopolamine in normal and NE-depleted mice. Pretraining administration of scopolamine impaired 24-h retention of inhibitory (passive) avoidance training (at doses of 0.1, 0.3 and 1.0 mg/kg) and the acquisition of place-training in a water maze (at a dose of 1.0 mg/kg). NE depletion resulting from systemic administration of DSP-4 did not affect performance on these tasks and did not significantly alter the effects of scopolamine. NE depletion did, however, impair the retention of place learning when mice were retested 16 days after initial training; and this impairment in the retest was additive with one observed in mice originally trained under scopolamine. Normal acquisition but rapid forgetting has also been reported in aged rodents, who display deterioration of the noradrenergic system. Thus, observation of a similar pattern of performance consequent to experimental NE depletion suggests a role for noradrenergic dysfunction in age-related memory decline.
journal_name
Brain Resjournal_title
Brain researchauthors
Decker MW,McGaugh JLdoi
10.1016/0006-8993(89)91391-7subject
Has Abstractpub_date
1989-01-16 00:00:00pages
29-37issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91391-7journal_volume
477pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In the present study, we used an immunocytochemical technique at the electron microscopic level to determine if there are changes in the glutamate and GABA neurotransmitter content of the hippocampus of genetic absence epilepsy rats from Strasbourg (GAERS). We also investigated if there was mossy fiber reorganization....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03349-3
更新日期：2003-10-24 00:00:00
abstract：:In order to elucidate the mechanisms that PKCγ regulates neuropathic pain (NP), and detect proteins that are associated with the function of PKCγ in NP, we exploited a chronic constriction injury (CCI)-induced neuropathic pain rat (CCI-NP rat) model in which PKCγ knockdown in the spinal cord was successfully carried o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.046
更新日期：2012-02-27 00:00:00
abstract：:The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91667-2
更新日期：1987-12-15 00:00:00
abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.024
更新日期：2010-04-09 00:00:00
abstract：:The role of gangliosides in preventing neuronal degeneration was examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse parkinsonian model. Intraventricular injections of a ganglioside mixture prior to MPTP treatment reduced MPTP's toxicity on tyrosine hydroxylase-positive neurons in the subst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91154-9
更新日期：1990-09-17 00:00:00
abstract：:Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90752-7
更新日期：1983-10-16 00:00:00
abstract：:Several reports during the last three decades have indicated that biosynthesis of N-acetylaspartate (NAA) occurs primarily in the mitochondria. But a recent report by Lu et al. in this journal [2004; 122: 71-78] and subsequent two reports that cited those data suggested a predominant microsomal localization of the NAA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.040
更新日期：2008-08-28 00:00:00
abstract：:Huntington's disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.042
更新日期：2012-04-23 00:00:00
abstract：:The effects of selective dopamine D1 (SKF 38393) and D2 (4-propyl-9-hydroxynaphthoxazine or PHNO) agonists on free-running rhythms of locomotor activity in rats were investigated under either constant light (LL) or dark (DD) condition. Rats under the DD condition exhibited clear circadian patterns of activity, while c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90445-2
更新日期：1991-01-11 00:00:00
abstract：:The stress-hyperresponsive Wistar-Kyoto (WKY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling in the midbrain periaqueductal grey (PAG) modulates pain. This study characterised PPAR signalling...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.022
更新日期：2017-02-15 00:00:00
abstract：:Current and voltage clamp recordings were made with a patch-clamp technique from large, light, dorsal root ganglia (DRG) neurons in tissue culture, derived from trisomy 16 and normal fetal mice. In a Na gradient of [52 mM]o/[28 mM]i, the action potential was accelerated, depolarization and repolarization were faster a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90052-1
更新日期：1988-02-01 00:00:00
abstract：:Using cervical sympathectomized and immobilized rabbits, the relationship between the luminance intensity and the magnitude of the response in pupillo-constrictor units of the ciliary nerve was investigated. It was revealed that the intensity--response relationship of the units closely resembled that of retinal recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90787-8
更新日期：1980-11-10 00:00:00
abstract：:Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91596-4
更新日期：1987-12-01 00:00:00
abstract：:Two distinct patterns of terminal labeling were seen after injections of [3H]amino acids into the second somatosensory area (S2) and the retroinsular area (Ri). The first pattern, seen both in S2 after an injection in Ri and in the granular or dysgranular insular fields after an injection in S2, is characterized by he...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91103-4
更新日期：1983-08-22 00:00:00
abstract：:While schizophrenia has a genetic component, its pathogenesis is unknown. Abnormal concentrations of two cell recognition molecules (CRMs), neural-cell adhesion molecule (N-CAM) and L1 antigen have been described in the cerebrospinal fluid (CSF) of patients with schizophrenia. Studies of monozygotic twins discordant f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00023-1
更新日期：1997-03-14 00:00:00
abstract：:Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.09.020
更新日期：2016-11-15 00:00:00
abstract：:Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.12.031
更新日期：2015-03-10 00:00:00
abstract：:In the search for cortical mechanisms subserving psychological phenomena, a better understanding of human cortical circuitry is crucial. In this report we describe aspects of intrinsic connectivity of supragranular layers in human visual cortex, revealed by extracellular injections of the anterograde tracer biocytin i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91148-8
更新日期：1992-10-30 00:00:00
abstract：:Opioid modulation of calcium currents was studied in acutely dissociated rat basal forebrain neurons using the whole cell patch-clamp recording technique. The mu-opioid receptor agonist DAGO reversibly suppressed high-voltage activated calcium currents and slowed their rate of activation, while neither delta- nor kapp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00206-0
更新日期：1997-05-30 00:00:00
abstract：:The ultrastructure of the dorsal column nucleus (DCN) has been investigated at the level of the obex region in normal and experimental toads. Large 'isolated' neurons (greater than 20 micrometer) and clusters of small neurons (less than 20 micrometer) have been identified in this region. Synaptic profiles have been cl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90905-8
更新日期：1978-03-10 00:00:00
abstract：:Lifelong bilingualism is associated with the delayed diagnosis of dementia, suggesting bilingual experience is relevant to brain health in aging. While the effects of bilingualism on cognitive functions across the lifespan are well documented, less is known about the neural substrates underlying differential behaviour...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.034
更新日期：2015-07-01 00:00:00
abstract：:Mammalian neostriatum is composed of two neurochemically and neuroanatomically defined compartments, called the patches and matrix. The present study concerns a search for neurochemical molecules involved in formation of the striatal compartments. Using the monoclonal antibody CR-50, we here disclose a transient expre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02136-8
更新日期：1999-12-11 00:00:00
abstract：:Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90715-7
更新日期：1984-05-14 00:00:00
abstract：:Depolarization by K+ (50 mM) of cultured chick retina cells released 1.14 +/- 0.28% of the accumulated [3H] gamma-aminobutyric acid (GABA) in the absence of Ca2+, but when 1.0 mM Ca2+ was present, the internal free calcium ion concentration [Ca2+]i rose by about 750 nM and the [3H]GABA release about doubled to a value...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90974-e
更新日期：1992-09-18 00:00:00
abstract：:Primary afferent neurons in mammalian dorsal root ganglia (DRGs) normally function as independent sensory communication elements. However, it has recently been shown that most DRG neurons are transiently activated when axons of neighboring neurons of the same ganglion are stimulated repetitively and the cross-depolari...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02342-4
更新日期：2003-04-25 00:00:00
abstract：:These experiments were conducted in order to better understand the role of catecholaminergic neurons in intracranial self-stimulation behaviour (ICSS) elicited from the lateral hypothalamus (LH). Two strains of mice which differ in their ICSS rate and their thresholds were studied. In a first time, we compared the cat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90341-4
更新日期：1983-04-18 00:00:00
abstract：:Sleep is posited to be a fundamental property of groups of highly interconnected neurons and regulated in part by activity-dependent sleep regulatory substances such as tumor necrosis factor alpha (TNFalpha). We show that the unilateral local application of TNFalpha onto the somatosensory cortex of rats induced state-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.02.055
更新日期：2004-05-29 00:00:00
abstract：:Microinjection of cholinergic agonists into the pontine tegmentum was used to evoke a state which was polygraphically and behaviorally similar to desynchronized (D) sleep. This study was designed to test the hypothesis that the production of this pharmacologically induced D sleep-like state (D-ACh) was dependent upon ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90005-9
更新日期：1987-06-30 00:00:00
abstract：:Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90818-0
更新日期：1981-10-26 00:00:00
abstract：:Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02768-9
更新日期：2003-07-18 00:00:00
