Abstract：
:Intrathecally-administered clonidine inhibited the spontaneous firing of single neurons in the pontine nucleus locus coeruleus of rats. Such inhibition of neuron firing was not observed when the non-lipophilic alpha 2 adrenoceptor agonist (oxymetazoline) was administered intrathecally. It is concluded that lipophilic drugs like clonidine, when administered intrathecally, can have profound supraspinal actions and thus caution should be exercised in interpreting the sites of action of such drugs.
journal_name
Brain Resjournal_title
Brain researchauthors
Marwaha J,Kehne JH,Commissaris RL,Lakoski J,Shaw W,Davis Mdoi
10.1016/0006-8993(83)90752-7subject
Has Abstractpub_date
1983-10-16 00:00:00pages
379-83issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90752-7journal_volume
276pub_type
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