Abstract:
:The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and the main medulla oblongata regions. In hippocampal formation the stratum lucidum and the stratum lacunosum moleculare of CA3 show an important density of glibenclamide binding sites. Electrophysiological studies with hippocampal slices show that glibenclamide blocks hyperpolarization induced by anoxia, suggesting the involvement of adenosine triphosphate-sensitive K+ channel in this early hyperpolarization event.
journal_name
Brain Resjournal_title
Brain researchauthors
Mourre C,Ben Ari Y,Bernardi H,Fosset M,Lazdunski Mdoi
10.1016/0006-8993(89)91288-2subject
Has Abstractpub_date
1989-05-01 00:00:00pages
159-64issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91288-2journal_volume
486pub_type
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