Selective dopamine D1 and D2 agonists independently affect different components of the free-running circadian rhythm of locomotor activity in rats.

abstract：:Sprague-Dawley rats were submitted to bilateral ventral hippocampus lesions 7 days after birth according to the Lipska and Weinberger's procedure for modeling schizophrenia. The aim of the present work was to better characterize their learning capacity. A double latent inhibition study was conducted using respectively...

journal_title：Brain research

authors： Angst MJ,Macedo CE,Guiberteau T,Sandner G

更新日期：2007-04-27 00:00:00

abstract：:Recent reports have identified discrepancies between the anatomical distribution of transmitters and their receptors, a phenomenon known as transmitter-receptor mismatch. However, quantitative determinations of transmitter activity and receptor density in individual brain regions have not been conducted in parallel. W...

journal_title：Brain research

authors： Ernsberger P,Arneric SP,Arango V,Reis DJ

更新日期：1988-06-14 00:00:00

abstract：:The neurotoxic compound 2,5-hexanedione (2,5-HD) causes an axonopathy characterized by the presence of neurofilament (NF)-containing enlargements in the preterminal segments of central and peripheral axons. The 2,5-HD axonopathy is a good model for human acquired and inherited giant axonal neuropathies. Recently, we r...

journal_title：Brain research

authors： Monaco S,Jacob J,Jenich H,Patton A,Autilio-Gambetti L,Gambetti P

更新日期：1989-07-10 00:00:00

abstract：:The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...

journal_title：Brain research

authors： Gerashchenko D,Shiromani PJ

更新日期：2004-09-03 00:00:00

abstract：:It has been hypothesised that the increased life span commonly observed in rodents that have had their diet restricted after weaning may be related to its effects on the anti-oxidant defence systems. However, undernutrition during the gestation and pre-weaning period is known to have long-term deleterious effects on a...

journal_title：Brain research

authors： Partadiredja G,Worrall S,Simpson R,Bedi KS

更新日期：2008-07-30 00:00:00

abstract：:The modulation of tetrodotoxin-sensitive (TTX-S) and slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons by ATP was studied using the whole-cell patch-clamp method. The effects of ATP on two types of sodium currents were either stimulatory or inhibitory depending on the kinetic para...

journal_title：Brain research

authors： Joo Choi E,Hong MP,Kyoo Shin Y,Soo Lee C,Park M,Song JH

更新日期：2003-04-04 00:00:00

abstract：:Peripheral afferent innervation appears to be required for the expression of the dopamine phenotype in the rodent main olfactory bulb. Experiments utilizing neonatal naris closure as a means of sensory deprivation also suggest that odor-induced afferent activity is required for the expression of the phenotype. These e...

journal_title：Brain research

authors： Baker H,Morel K,Stone DM,Maruniak JA

更新日期：1993-06-18 00:00:00

abstract：:Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion...

journal_title：Brain research

authors： Lephart ED,Ladle DR,Jacobson NA,Rhees RW

更新日期：1996-11-11 00:00:00

abstract：:An endogenous asymmetry in striatal dopaminergic function has been identified in rats, and related to spontaneous and drug-induced circling (rotation, turning). We have developed an electronic device for measuring in humans the same kinds of rotational movements observed in rats. Our data indicate that, without being ...

journal_title：Brain research

authors： Bracha HS,Seitz DJ,Otemaa J,Glick SD

更新日期：1987-05-19 00:00:00

abstract：:Single pulse stimuli were delivered to the Schaffer collaterals in the in vitro hippocampal slice preparation. Local application of bicuculline to the CA3 region resulted in a series of population cell bursts in CA3, resembling the neuronal patterns which occur in the normal, freely moving rat during hippocampal sharp...

journal_title：Brain research

authors： Buzsáki G,Haas HL,Anderson EG

更新日期：1987-12-01 00:00:00

abstract：:The distribution of agmatine (decarboxylated arginine) was mapped in the central nervous system (CNS) in the rat. Agmatine-like immunoreactivity was identified by light microscopy, exclusively in the cytoplasm of neuronal perikarya. Immunoreactive neurons were present in the cerebral cortex, predominantly within lamin...

journal_title：Brain research

authors： Otake K,Ruggiero DA,Regunathan S,Wang H,Milner TA,Reis DJ

更新日期：1998-03-16 00:00:00

abstract：:At two weeks post-transplantation, sciatic nerves inserted into the lesioned septo-hippocampal pathway contain NGF levels more than twice that of normal nerves. These transplanted nerves also contain regenerating cholinergic axons. Moreover, transplanted animals exhibit septal NGF levels that are significantly greater...

journal_title：Brain research

authors： Messersmith DJ,Fabrazzo M,Mocchetti I,Kromer LF

更新日期：1991-08-23 00:00:00

abstract：:The origin of descending pathways to thoracic and cervical levels of the spinal cord has been investigated with retrograde tracing techniques in a series of pouch young and adult opossums. The opossum was chosen because it is born in a very immature state, 12-13 days after conception, and has a protracted development ...

journal_title：Brain research

authors： Cabana T,Martin GF

更新日期：1984-08-01 00:00:00

abstract：:Serial ion-exchange and high-performance liquid chromatography separations were employed for the tissue extraction and purification of kynurenic acid (KYNA). Subsequently, the compound isolated from postmortem human brain tissue was unequivocally identified as KYNA by nuclear magnetic resonance and mass spectrometric ...

journal_title：Brain research

authors： Turski WA,Nakamura M,Todd WP,Carpenter BK,Whetsell WO Jr,Schwarcz R

更新日期：1988-06-28 00:00:00

abstract：:Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the me...

journal_title：Brain research

authors： Liu W,Kumar A,Alreja M

更新日期：1998-09-14 00:00:00

abstract：:Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...

journal_title：Brain research

authors： Warton SS,Jones DG

更新日期：1984-05-01 00:00:00

abstract：:Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...

journal_title：Brain research

authors： Cameron AA,Dougherty PM,Garrison CJ,Willis WD,Carlton SM

更新日期：1993-08-20 00:00:00

abstract：:In addition to its stimulatory effect on prolactin release, the neuropeptide prolactin releasing peptide (PrRP) has been shown to be a mediator of the stress response. To analyze the neurochemical properties of the cells responsive to PrRP and involved in stress modulation, we examined PrRP receptor co-expression with...

journal_title：Brain research

authors： Lin SH,Leslie FM,Civelli O

更新日期：2002-10-11 00:00:00

abstract：:Numerous studies of neonatal neuronal development in mammals have revealed that neuronal cell death following axotomy is apoptotic in nature. In adult animals, however, neuronal cell death following axonal injury may or may not exhibit features of apoptosis. Bcl-2 and Bax have been identified as inhibitor and promoter...

journal_title：Brain research

authors： Baba N,Koji T,Itoh M,Mizuno A

更新日期：1999-05-08 00:00:00

abstract：:To determine whether the paraventricular nucleus (PVN) contributes to the development of hypertension in spontaneously hypertensive rats (SHR), we compared cardiovascular responses to ganglionic blockade with hexamethonium or vasopressin antagonism with dPVAVP in sham-operated or PVN lesioned SHR and Wistar-Kyoto rats...

journal_title：Brain research

authors： Takeda K,Nakata T,Takesako T,Itoh H,Hirata M,Kawasaki S,Hayashi J,Oguro M,Sasaki S,Nakagawa M

更新日期：1991-03-15 00:00:00

abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

journal_title：Brain research

authors： Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

更新日期：1993-04-02 00:00:00

abstract：:We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also supp...

journal_title：Brain research

authors： Shin C,Rigsbee LC,McNamara JO

更新日期：1986-11-29 00:00:00

abstract：:In the present study we have examined the effects of changes in potassium and calcium concentration on the early adaptation of the slowly adapting stretch receptor of the crayfish using intracellular recordings including the potential clamp technique. This was because previous studies had suggested that the early adap...

journal_title：Brain research

authors： Ottoson D,Swerup C

更新日期：1985-06-10 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) isolated from the brain and pituitary, has been shown to induce cell divisions in a variety of cell types. It also acts as a potent stimulator of angiogenesis, and it is important in the survival of several types of cultured neurons. Despite considerable information on the functio...

journal_title：Brain research

authors： Matsuda S,Desaki J,Okumura N,Shiosaka S,Imaoka S,Sakanaka M

更新日期：1992-04-10 00:00:00

abstract：:Previous electrophysiological as well as imaging research has contributed to the understanding of impairments in attention, executive functions, and memory in patients with attention-deficit/hyperactivity disorder (ADHD). However, there is a lack of studies investigating ADHD related differences in the gamma range of ...

journal_title：Brain research

authors： Lenz D,Krauel K,Schadow J,Baving L,Duzel E,Herrmann CS

更新日期：2008-10-15 00:00:00

abstract：:The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...

journal_title：Brain research

authors： Zhang J,Chiodo LA,Freeman AS

更新日期：1992-09-11 00:00:00

abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

journal_title：Brain research

authors： Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

更新日期：1992-03-06 00:00:00

abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...

journal_title：Brain research

authors： Pigott R,Kelly JS

更新日期：1986-09-01 00:00:00

abstract：:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...

journal_title：Brain research

authors： Schmahl W,Funk R,Miaskowski U,Plendl J

更新日期：1989-05-08 00:00:00

abstract：:The block of the transient outward K-current, I(K(A)) by 4-aminopyridine (4-AP) and blood-depressing substances (BDS) was investigated in identified Helix pomatia neurons (LPa3) using the two microelectrode voltage-clamp technique. The present study shows that 4-AP inhibits I(K(A)) in snail neurons in a voltage- and c...

journal_title：Brain research

authors： Kiss T,László Z,Szabadics J

更新日期：2002-02-15 00:00:00