Abstract:
:The neurotoxic compound 2,5-hexanedione (2,5-HD) causes an axonopathy characterized by the presence of neurofilament (NF)-containing enlargements in the preterminal segments of central and peripheral axons. The 2,5-HD axonopathy is a good model for human acquired and inherited giant axonal neuropathies. Recently, we reported that following 2,5-HD administration, axonal transport of NF is markedly and selectively accelerated in the primary visual system. We have now studied slow axonal transport in the sciatic system of rats intoxicated with 0.5% 2,5-HD in drinking water. Following radiolabeling, transported proteins were examined after polyacrylamide gel electrophoresis and fluorography. The bulk of radiolabeled NF subunits was located 30-50 mm from the spinal cord in 2,5-HD treated animals and 10-25 mm in controls. The rate of transport of the three NF subunits was 0.7 mm/day in controls and 1.2 mm/day in 2,5-HD treated animals. The rate of transport of tubulin was not significantly changed. Electrophysiological studies of soleus nerve and muscle showed no evidence of denervation after 6 weeks of intoxication. It is concluded that, following 2,5-HD administration, transport of NF is preferentially accelerated in both central and peripheral axons. A pathogenetic mechanism based on the acceleration of NF transport is proposed, which may explain the formation and the distal or proximal location of NF-containing axonal enlargements in giant axonopathies.
journal_name
Brain Resjournal_title
Brain researchauthors
Monaco S,Jacob J,Jenich H,Patton A,Autilio-Gambetti L,Gambetti Pdoi
10.1016/0006-8993(89)90067-xsubject
Has Abstractpub_date
1989-07-10 00:00:00pages
328-34issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90067-Xjournal_volume
491pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In decerebrate cats, the extracellular activities of neurons in the medial medullary reticular formation were studied during constant velocity off-vertical axis rotations (OVAR) in the clockwise (CW) and counterclockwise (CCW) directions (at 10 degrees tilt). Spontaneously active neurons demonstrated sinusoidal positi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00516-1
更新日期:1996-09-02 00:00:00
abstract::The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02659-2
更新日期:2001-08-10 00:00:00
abstract::Previous work has demonstrated that the GABAergic system is involved in sexual differentiation of the rodent hypothalamus. The present study was designed to further examine this involvement by investigating developmental sex differences in GAD(65) protein levels in hypothalamic and extrahypothalamic brain regions know...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03167-5
更新日期:2001-12-20 00:00:00
abstract::The role of descending monoaminergic pathways in the antinociceptive effect of baclofen following intraperitoneal (i.p.) administration was investigated by determining the effect of intrathecal (i.t.) administration of neurotoxins [6-hydroxydopamine (6-OHDA) and 5,6-dihydroxytryptamine (5,6-DHT)] and receptor antagoni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90279-3
更新日期:1985-05-27 00:00:00
abstract::The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.053
更新日期:2006-05-17 00:00:00
abstract::Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.080
更新日期:2008-04-14 00:00:00
abstract::The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90341-9
更新日期:1977-12-02 00:00:00
abstract::Behavioral responses to light tactile stimulation of the skin of the head of axolotls were variable in occurrence but were of a constant pattern. Retraction of the eyes and gills followed stimulation of dorsal but not ventral skin. Ventral skin yielded lowering of the head. Touching near the lips caused turning of the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90037-7
更新日期:1981-09-01 00:00:00
abstract::Quantitative morphological changes in the superior colliculus (SC) and the parabigeminal nucleus (PB) were studied in hereditary bilaterally microphthalmic rat, which lacks the optic nerve completely. Volumes of the retinorecipient superficial collicular layers of SC (SCS) to the central gray matter were decreased by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90012-4
更新日期:1985-11-01 00:00:00
abstract::Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.02.011
更新日期:2014-03-27 00:00:00
abstract::Rats trained to walk in a moving belt apparatus were subjected to a partial (fornix-fimbria (FF] or total (fornix-fimbria + cingulum bundles (FF + CB] chemical denervation of the dorsal serotonergic afferent pathways to the hippocampus. After chronic alcohol treatment that resulted in tolerance development to the moto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90037-x
更新日期:1985-02-11 00:00:00
abstract::Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90164-9
更新日期:1989-08-07 00:00:00
abstract::Time-course expression of Bax and Bcl-2 proteins, identified as apoptosis-regulating molecules, was assessed in gerbil hippocampus following transient forebrain ischemia. Brain sections from animals sacrificed at 48, 72, 96 h and 7 days following 5 min ischemia were immunohistochemically evaluated using polyclonal ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01436-5
更新日期:1996-03-04 00:00:00
abstract::In the present study, the light responses of ganglion cells to chromatic stimulus were recorded from isolated retina of neonatal chick. It was found that for some non-color-opponent ganglion cells, the spatiotemporal patterns of the cells' light responses were related to the chromatic information that they received. W...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.077
更新日期:2005-10-12 00:00:00
abstract::A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90285-x
更新日期:1987-07-07 00:00:00
abstract::Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90291-8
更新日期:1977-02-18 00:00:00
abstract::The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91037-2
更新日期:1991-02-15 00:00:00
abstract::Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more...
journal_title:Brain research
pub_type: 杂志文章
doi:
更新日期:1980-11-24 00:00:00
abstract:OBJECTIVE:Our asphyxia cardiac arrest (ACA) rat model is well established. The original model was designed in the 1990th using halothane and nitrous oxide for pre-insult anesthesia. Because of its hepato-toxicity and its potential to induce severe liver failures, halothane is no longer used in clinical anesthesia for s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.003
更新日期:2016-12-01 00:00:00
abstract::This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01561-9
更新日期:1999-07-24 00:00:00
abstract::From previous inverse dynamic analyses of human leg extensions, it was hypothesized that the underlying processes for the activation of mono- and biarticular muscles are different; the mono-articular muscles being activated when they shortened, whereas the biarticular muscles appeared responsible for the control of th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01327-3
更新日期:1997-03-21 00:00:00
abstract::Acetylcholinesterase activity, which may be indicative of cholinergic synapses, has been ultrastructurally localized in the outer plexiform layer of the larval tiger salamander retina using the cholinesterase staining method of Karnovsky and Roots. In the presence of the butyrylcholinesterase inhibitor, ethopropazine,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90766-2
更新日期:1984-02-06 00:00:00
abstract:UNLABELLED:The effects of acute and chronic exposure to phencyclidine (PCP) on the regulation of prolactin (PRL) secretion were examined. Female Sprague-Dawley rats were injected with PCP (10 mg/kg) or saline for 14 days, or just prior to the administration of the serotonin precursor, 5-hydroxytryptophan (5-HTP). A sin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90764-z
更新日期:1992-02-28 00:00:00
abstract::Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00848-8
更新日期:1998-10-19 00:00:00
abstract::Substance P(SP), the heptapeptide SP and the stable analogue (p-Glu5-MePhe8-MeGly9) SP (DiMe-C7) induce a Ca2+-dependent release of Met5-enkephalin (MET) from slices of periaqueductal gray matter (PAG) and striatum of rats. The MET release from striatal slices is greater than that from PAG slices because of the higher...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90169-5
更新日期:1983-11-21 00:00:00
abstract::Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01500-0
更新日期:1996-04-22 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) immunoreactivity in rat tissue was assayed using a new reversed-phase, ion-pair, high-pressure liquid chromatography (HPLC) method for separating TRH from its analogs. Virtually all of the TRH immunoreactivity in hypothalamus, brain stem, preoptic area, septum, striatum, frontal cor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91036-7
更新日期:1980-11-17 00:00:00
abstract::Intracranial pressure (ICP) was monitored to evaluate the therapeutic effect of hyperbaric oxygen (HBO(2)) treatment following traumatic brain injury (TBI). This subject is controversial. The aim of our study was to determine whether HBO(2) treatment has a therapeutic effect on ICP dynamics and survival following seve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.02.049
更新日期:2005-06-21 00:00:00
abstract::This manuscript describes the use of staining of Fos-related antigens (FRAs) as markers for changes in neuronal activity. The model system consisted of the tuberoinfundibular dopamine (TIDA) neurons located in the arcuate nucleus of the hypothalamus. Under normal conditions, these neurons are devoid of c-Fos staining ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90481-2
更新日期:1994-08-22 00:00:00
abstract::Buffy coat of three members from a family with Alzheimer's disease was inoculated into hamster brains. Eighteen months after the inoculation, all experimental animals were sacrificed for the neuropathological study. Hematoxylin-eosin staining showed no gross vacuolar degeneration, or neuronal loss in the cortex. The s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90949-v
更新日期:1991-06-14 00:00:00