Abstract：
:This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats (P>0.05 for both comparisons). The sensitivity of the BR-mediated tachycardia in AV3V-lesion was greater than in sham-lesion rats (-9. 92+/-1.00 vs. -4.54+/-0.45 bpm/mmHg, P<0.05). The sensitivity of the BR-mediated bradycardia in AV3V-lesion rats was also greater than in rats with sham lesions (-3.56+/-0.38 vs. -2.06+/-0.42 bpm/mmHg, P<0. 05). The AV3V lesions did not affect other BR parameters. These findings demonstrate that chronic lesions of the AV3V region increase the sensitivity of the baroreceptor HR reflex in conscious rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Lewis SJ,Whalen EJ,Beltz TG,Johnson AKdoi
10.1016/s0006-8993(99)01561-9subject
Has Abstractpub_date
1999-07-24 00:00:00pages
330-3issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)01561-9journal_volume
835pub_type
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