Substance P-induced release of Met5-enkephalin from striatal and periaqueductal gray slices.

abstract：:In order to elucidate the mechanisms that PKCγ regulates neuropathic pain (NP), and detect proteins that are associated with the function of PKCγ in NP, we exploited a chronic constriction injury (CCI)-induced neuropathic pain rat (CCI-NP rat) model in which PKCγ knockdown in the spinal cord was successfully carried o...

journal_title：Brain research

authors： Zou W,Zhan X,Li M,Song Z,Liu C,Peng F,Guo Q

更新日期：2012-02-27 00:00:00

abstract：:Evidence is presented which suggests that central neural changes occur during the brief early phase after subcutaneous formalin injection that are essential for the expression of pain during the long-lasting (tonic) later phase. First, tonic pain responses to subcutaneous formalin injections are abolished only if the ...

journal_title：Brain research

authors： Coderre TJ,Vaccarino AL,Melzack R

更新日期：1990-12-03 00:00:00

abstract：:The dentate gyrus is believed to play an important pathophysiological role during experimentally induced kindling. In this study, we investigated whether an altered content of the calcium binding protein calbindin-D(28k) or an increased intrinsic excitability of hippocampal granule cells contribute to the induction of...

journal_title：Brain research

authors： Dietrich D,Podlogar M,Ortmanns G,Clusmann H,Kral T

更新日期：2005-01-25 00:00:00

abstract：:The pleiotropic cytokine tumor necrosis factor-alpha (TNFalpha) is implicated in the development of persistent pain through its actions in the periphery and in the central nervous system (CNS). Activation of the alpha(2)-adrenergic receptor is associated with modulation of pain, possibly through its autoregulatory eff...

journal_title：Brain research

authors： Covey WC,Ignatowski TA,Knight PR,Spengler RN

更新日期：2000-03-17 00:00:00

abstract：:We have previously reported the first successful production of monoclonal antibodies against the cholinergic neuronal marker, choline acetyltransferase (ChAT). We now report some inter-and intraspecies cross-reactivity studies of the monoclonal antibody AB1. This antibody reacted most strongly with bovine ChAT and wea...

journal_title：Brain research

authors： Levey AI,Wainer BH

更新日期：1982-02-25 00:00:00

abstract：:We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...

journal_title：Brain research

authors： Cullheim S,Lipsenthal L,Burke RE

更新日期：1984-08-06 00:00:00

abstract：:Current and voltage clamp recordings were made with a patch-clamp technique from large, light, dorsal root ganglia (DRG) neurons in tissue culture, derived from trisomy 16 and normal fetal mice. In a Na gradient of [52 mM]o/[28 mM]i, the action potential was accelerated, depolarization and repolarization were faster a...

journal_title：Brain research

authors： Orozco CB,Epstein CJ,Rapoport SI

更新日期：1988-02-01 00:00:00

abstract：:In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...

journal_title：Brain research

authors： Hatip-Al-Khatib I,Mishima K,Iwasaki K,Fujiwara M

更新日期：2001-05-25 00:00:00

abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...

journal_title：Brain research

authors： Buchanan JA,Bilkey DK

更新日期：1997-10-10 00:00:00

abstract：:(1) Changes during development in the levels of proteinases and peptidases were measured in brain homogenates. At all ages di- and tripeptidase levels were 7-15-fold higher than proteinase activity. (2) Cathepsin A and D and neutral proteinase activity first decreased (during the 5 days before birth) and then increase...

journal_title：Brain research

authors： Marks N,Stern F,Lajtha A

更新日期：1975-03-21 00:00:00

abstract：:The current study examined the effects of intracerebroventricular (icv) infused aminopeptidase-resistant analogs of angiotensin II (AngII) and angiotensin III (AngIII) on thirst and sodium appetite. The analogs, [D-Asp1D-Arg2]AngII and [D-Arg1]AngIII, were further protected from degradation by pretreatment with the am...

journal_title：Brain research

authors： Wilson WL,Roques BP,Llorens-Cortes C,Speth RC,Harding JW,Wright JW

更新日期：2005-10-26 00:00:00

abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...

journal_title：Brain research

authors： Miletich RS,Comi G,Bankiewicz K,Plunkett R,Adams R,Di Chiro G,Kopin IJ

更新日期：1993-10-29 00:00:00

abstract：:Previous studies have indicated that central sensitization is a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation and astrocytes play an important role in the central sensitization. The current study investigated the role of amino ac...

journal_title：Brain research

authors： Wang J,Geng B,Shen HL,Xu X,Wang H,Wang CF,Ma JL,Wang ZP

更新日期：2012-04-17 00:00:00

abstract：:The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...

journal_title：Brain research

authors： Ninkovic M,Hunt SP,Kelly JS

更新日期：1981-12-28 00:00:00

abstract：:Voltage-clamped GABA(A fast) and GABA(A slow) inhibitory postsynaptic currents (IPSCs) were selectively elicited in hippocampal area CA1 pyramidal neurons. Clinically relevant concentrations of halothane (1.2 vol.%) prolonged both GABA(A fast) and GABA(A slow) IPSC decay times approximately 2.5 fold, while having litt...

journal_title：Brain research

authors： Lukatch HS,MacIver MB

更新日期：1997-08-08 00:00:00

abstract：:Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...

journal_title：Brain research

authors： Brody KM,Taylor JM,Wilson GR,Delatycki MB,Lockhart PJ

更新日期：2008-03-27 00:00:00

abstract：:The homozygous Brattleboro rat (di/di), displaying a hypothalamic form of diabetes insipidus, synthesizes a vasopressin (VP) precursor with an abnormal C-terminus. The phenotypic expression of coexisting peptides in mutant magnocellular VP cells shows a differential pattern. 7B2 is one of the peptides which is not det...

journal_title：Brain research

authors： Gabreëls BA,Sonnemans MA,Seidah NG,Chrétien M,van Leeuwen FW

更新日期：1992-07-10 00:00:00

abstract：:Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the ...

journal_title：Brain research

authors： Bellin SI,Bhatnagar RK,Johnson AK

更新日期：1987-02-10 00:00:00

abstract：:The distinction between neural mechanisms of explicit and implicit expressions of memory has been well studied at the retrieval stage, but less at encoding. In addition, dissociations obtained in many studies are complicated by methodological difficulties in obtaining process-pure measures of different types of memory...

journal_title：Brain research

authors： Meng Y,Ye X,Gonsalves BD

更新日期：2014-10-17 00:00:00

abstract：:Surgical microscopy and electrophysiological techniques were used to standardize the nomenclature for the pudendal nerve and sacral plexus according to their somatic axonal composition in the male rat. We conclude that the pudendal nerve is the segment running from the L6-S1 trunk to the sacral plexus, carrying effere...

journal_title：Brain research

authors： Pacheco P,Camacho MA,García LI,Hernández ME,Carrillo P,Manzo J

更新日期：1997-07-25 00:00:00

abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...

journal_title：Brain research

authors： Lee KS,Reddington M

更新日期：1986-03-19 00:00:00

abstract：:A basic experiment of peripheral nerve regeneration using neuronal progenitor cells embedded in collagen gel was performed in a rat sciatic nerve defect. First, when neuronal progenitor cells derived from the fetal rat hippocampus were cultured in atelocollagen-containing medium, neurospheres positive for anti-nestin ...

journal_title：Brain research

authors： Murakami T,Fujimoto Y,Yasunaga Y,Ishida O,Tanaka N,Ikuta Y,Ochi M

更新日期：2003-06-06 00:00:00

abstract：:In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...

journal_title：Brain research

authors： Inenaga K,Dyball RE,Okuya S,Yamashita H

更新日期：1986-03-26 00:00:00

abstract：:The calcium channel antagonists omega-agatoxin IIIA (omega-Aga-IIIA) and omega-conotoxin GVIA (omega-CgTx) were radioiodinated and used to locate binding sites in the rat brain by receptor autoradiography. While patterns of regional binding to sagittal sections of rat brain were generally similar for the 2 toxins, not...

journal_title：Brain research

authors： McIntosh JM,Adams ME,Olivera BM,Filloux F

更新日期：1992-10-23 00:00:00

abstract：:The lateral geniculate nucleus (LGN) of a fetal rat was transplanted to the visual cortex (VC) of a neonatal rat. A current source-density analysis of field potentials and an intracellular study of neuronal responses were conducted in slice preparations by electrical stimulation of transplanted LGN and host VC. The re...

journal_title：Brain research

authors： Hamasaki T,Komatsu Y,Yamamoto N,Nakajima S,Hirakawa K,Toyama K

更新日期：1987-09-29 00:00:00

abstract：:The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...

journal_title：Brain research

authors： Sparks GM,Brailoiu E,Brailoiu GC,Dun NJ,Tabor J,Cooper RL

更新日期：2003-04-18 00:00:00

abstract：:Using [3H]para-aminoclonidine, alpha 2 adrenergic binding sites have been mapped in the rat and human CNS using in vitro labeling autoradiographic techniques. In both the rat and human thoracic spinal cord, high densities of alpha 2 binding sites were associated with the substantia gelatinosa and the intermediolateral...

journal_title：Brain research

authors： Unnerstall JR,Kopajtic TA,Kuhar MJ

更新日期：1984-03-01 00:00:00

abstract：:We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wh...

journal_title：Brain research

authors： Shimada S,Shiosaka S,Hillyard CJ,Girgis SI,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-09-30 00:00:00

abstract：:Somatosensory information has been thought to ascend from the spinal cord to limbic areas of the telencephalon through indirect, multisynaptic pathways. We now report that injections of Fluoro-gold into either the nucleus accumbens or the septal nuclei labeled hundreds of neurons in the spinal cord. These and our rece...

journal_title：Brain research

authors： Burstein R,Giesler GJ Jr

更新日期：1989-09-11 00:00:00

abstract：:Few clinical or experimental studies have carried out systematic investigations of cutaneous and deep sensibility in areas with referred muscle pain. Therefore, no clear signs of increased or decreased psychophysical responses to various somatosensory stimuli are found in referred pain areas. In the present study, a t...

journal_title：Brain research

authors： Graven-Nielsen T,Arendt-Nielsen L,Svensson P,Jensen TS

更新日期：1997-01-02 00:00:00