Cross-species and intraspecies reactivities of monoclonal antibodies against choline acetyltransferase.

abstract：:The effect of an extended program of perforant path or amygdala kindling on paired-pulse suppression in the dentate gyrus was studied in male hooded rats. Repeated kindling stimulations were delivered twice or three times daily until either 300 stimuli had been delivered or generalized convulsions had been observed to...

journal_title：Brain research

authors： Milgram NW,Michael M,Cammisuli S,Head E,Ferbinteanu J,Reid C,Murphy MP,Racine R

更新日期：1995-01-23 00:00:00

abstract：:Pericyte coverage on the endothelial tubes leads to the formation of a mature and stable microvessel system, which is critical for brain repair after intracerebral hemorrhage (ICH). We report herein that thrombin promotes pericyte coverage by activating Tie2 and the downstream signaling pathway PI3K/Akt in a rat model...

journal_title：Brain research

authors： Hu E,Hu W,Yang A,Zhou H,Zhou J,Luo J,Wang Y,Tang T,Cui H

更新日期：2019-04-01 00:00:00

abstract：:The distribution of iron in the brain of a vocal learning parrot, the budgerigar (Melopsittacus undulatus), was examined using iron histochemistry. In mammals, iron is a highly specific stain for the dorsal and ventral pallidal subdivision as well as specific cell groups in the brainstem, including the substantia nigr...

journal_title：Brain research

authors： Roberts TF,Brauth SE,Hall WS

更新日期：2001-12-07 00:00:00

abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...

journal_title：Brain research

authors： Brundin P,Isacson O,Gage FH,Björklund A

更新日期：1986-01-01 00:00:00

abstract：:The organization of globus pallidus (GP) projections was studied in cats using autoradiographic and horseradish peroxidase (HRP) techniques. Both methods confirmed the existence of a topographically organized projection to subthalamic nucleus (STN). Although all but the most caudal GP projects to STN, the heaviest pro...

journal_title：Brain research

authors： McBride RL,Larsen KD

更新日期：1980-05-05 00:00:00

abstract：:Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular synapses of Drosophila double mutant for comatose (an NSF mutant) and Kum (a SERCA mutant), and presen...

journal_title：Brain research

authors： Freeman A,Bowers M,Mortimer AV,Timmerman C,Roux S,Ramaswami M,Sanyal S

更新日期：2010-04-22 00:00:00

abstract：:Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal pigmental epithelium where DOPA facilitates the pigmentati...

journal_title：Brain research

authors： Fukuda N,Naito S,Masukawa D,Kaneda M,Miyamoto H,Abe T,Yamashita Y,Endo I,Nakamura F,Goshima Y

更新日期：2015-03-30 00:00:00

abstract：:Experimental thiamine deficiency (TD) is a model of impaired oxidative metabolism associated with region-selective neuronal loss in the brain. Oxidative stress is a prominent feature of TD neuropathology, as evidenced by the accumulation of heme oxygenase-1 (HO-1), ferritin, reactive iron and superoxide dismutase in m...

journal_title：Brain research

authors： Calingasan NY,Gibson GE

更新日期：2000-12-01 00:00:00

abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...

journal_title：Brain research

authors： Inoue Y,Nakamura R,Mikoshiba K,Tsukada Y

更新日期：1981-08-24 00:00:00

abstract：:Radial glial cells of the embryonic murine cerebral wall are selectively labeled by staining with antibody RC1. In order to study the mitotic cycling of these cells, we combined RC1 immunohistochemistry and autoradiographic analysis following [3H]thymidine injection at 1, 2, 6, 48 h prior to sacrifice. Many radial gli...

journal_title：Brain research

authors： Misson JP,Edwards MA,Yamamoto M,Caviness VS Jr

更新日期：1988-02-01 00:00:00

abstract：:The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...

journal_title：Brain research

authors： Wells MR,Bernstein JJ

更新日期：1976-07-23 00:00:00

abstract：:Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...

journal_title：Brain research

authors： Ulfig N,Braak E,Ohm TG,Pool CW

更新日期：1990-10-15 00:00:00

abstract：:The ultrastructural features of the serotoninergic innervation of the rat dentate gyrus in normal adults and in animals receiving raphe nuclear area transplants was investigated using an antibody to serotonin (5-HT). Neonatal rats received a lesion of the fimbria-fornix and entorhinal cortex. Three days later, a porti...

journal_title：Brain research

authors： Anderson KJ,Holets VR,Mazur PC,Lasher RS,Cotman CW

更新日期：1986-03-26 00:00:00

abstract：:In light of the evidence that calcium plays a critical role in excitotoxic neuronal death, it has been speculated that the metabotropic glutamate receptor may also contribute to excitotoxic damage through the mobilization of Ca2+ from intracellular stores. In the present study we examined this possibility by studying ...

journal_title：Brain research

authors： Koh JY,Palmer E,Lin A,Cotman CW

更新日期：1991-10-11 00:00:00

abstract：:alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...

journal_title：Brain research

authors： Yue TL,Barone FC,Gu JL,Feuerstein GZ

更新日期：1993-04-30 00:00:00

abstract：:GABA levels, high affinity GABA uptake and glutamic acid decarboxylase levels are reduced in rat ventroanterolateral thalamic nucleus after destruction of the entopeduncular nucleus with kainic acid. This is strong evidence that GABA is an entopedunculothalamic neurotransmitter. The striatoentopeduncular pathway is al...

journal_title：Brain research

authors： Penney JB Jr,Young AB

更新日期：1981-02-23 00:00:00

abstract：:In pentobarbital-anesthetized rats, responses of single neurons in ventrolateral orbital cortex (VLO) to noxious visceral (colorectal distension, CRD) and cutaneous stimulation were recorded. Of 71 neurons identified on the basis of spontaneous activity, 44 responded to CRD. CRD caused inhibition of neuronal activity ...

journal_title：Brain research

authors： Follett KA,Dirks B

更新日期：1995-01-16 00:00:00

abstract：:Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...

journal_title：Brain research

authors： Tatro JB

更新日期：1990-12-17 00:00:00

abstract：:Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...

journal_title：Brain research

authors： Tsao W,Jeong YH,Lin S,Ling J,Price DL,Chiang PM,Wong PC

更新日期：2012-06-26 00:00:00

abstract：:Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neurop...

journal_title：Brain research

authors： Tsuboi K,Kimber TA,Shults CW

更新日期：2000-06-02 00:00:00

abstract：:Intracellular transport of newly synthesized proteins through organelles in the perikarya of regenerating goldfish retinal ganglion cells was studied using electron microscopic autoradiography. Retinas were removed 14 or 30 days after optic tract cut or sham operation, pulse-labeled in [3H]proline-containing medium fo...

journal_title：Brain research

authors： Whitnall MH,Grafstein B

更新日期：1982-05-06 00:00:00

abstract：:Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

journal_title：Brain research

authors： Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

更新日期：2002-10-04 00:00:00

abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...

journal_title：Brain research

authors： Saito N,Itouji A,Totani Y,Osawa I,Koide H,Fujisawa N,Ogita K,Tanaka C

更新日期：1993-04-02 00:00:00

abstract：:Interactions between brain alpha2- and beta-adrenoceptors are of interest in physiological (aging) and pathological (major depression) processes involving both receptors. In this study, total beta-adrenoceptors and beta1/2-subtypes were quantitated in postmortem human brains to investigate their relationships with alp...

journal_title：Brain research

authors： Sastre M,Guimón J,García-Sevilla JA

更新日期：2001-04-20 00:00:00

abstract：:The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...

journal_title：Brain research

authors： Weber YG,Geiger J,Kämpchen K,Landwehrmeyer B,Sommer C,Lerche H

更新日期：2006-03-10 00:00:00

abstract：:The electrophysiological characteristics of physiologically typed L7 and S1 dorsal root ganglion (DRG) cells have been studied in the cat by intracellular recording. The injection of the fluorescent dye Lucifer Yellow has enabled us to study the morphology of these neurons. Our results show that over the entire range ...

journal_title：Brain research

authors： Cameron AA,Leah JD,Snow PJ

更新日期：1986-01-01 00:00:00

abstract：:A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challen...

journal_title：Brain research

authors： Wegener G,Linnet K,Rosenberg R,Mørk A

更新日期：2000-07-21 00:00:00

abstract：:The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...

journal_title：Brain research

authors： Altobelli GG,Cimini V

更新日期：2007-02-09 00:00:00

abstract：:The localization of human hand primary motor area (M1) has been the object of several studies during the last decades. EEG source analysis, functional magnetic resonance imaging (fMRI) and focal transcranial magnetic stimulation (TMS) are non-invasive methods for localizing M1 with good accuracy compared to direct ele...

journal_title：Brain research

authors： Inuggi A,Filippi M,Chieffo R,Agosta F,Rocca MA,González-Rosa JJ,Cursi M,Comi G,Leocani L

更新日期：2010-01-13 00:00:00

abstract：:In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...

journal_title：Brain research

authors： Park SY,Lee JH,Kim CD,Rhim BY,Hong KW,Lee WS

更新日期：2007-07-09 00:00:00