The electrophysiological and morphological characteristics of feline dorsal root ganglion cells.

Abstract:

:The electrophysiological characteristics of physiologically typed L7 and S1 dorsal root ganglion (DRG) cells have been studied in the cat by intracellular recording. The injection of the fluorescent dye Lucifer Yellow has enabled us to study the morphology of these neurons. Our results show that over the entire range of primary sensory afferents there is a linear relationship between the peak rate of rise of somatic action potentials (dv/dt) and axonal conduction velocity. There is a prominent inflexion on the repolarizing phase of the somatic action potentials of group III and group IV afferents. This is not seen in the action potentials of group II or group I afferents. These results correlate with the observation that the total action potential duration (APD) is inversely related to conduction velocity. Primary afferent somata were observed to have an ellipsoidal shape with the long axis in the rostrocaudal dimension. It was observed that for all afferents studied the volume of a dorsal root ganglion cell was linearly related to its peripheral axonal conduction velocity. We were able to show further that group IV somata, some of whose axons supplied nociceptors, were among the smallest in the ganglion.

journal_name

Brain Res

journal_title

Brain research

authors

Cameron AA,Leah JD,Snow PJ

doi

10.1016/0006-8993(86)91391-0

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

1-6

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)91391-0

journal_volume

362

pub_type

杂志文章
  • Grafting of midbrain neurons into the hippocampus restores serotonergic modulation of hippocampal activity in the rat.

    abstract::The ability of midbrain raphe (MR) cells grafted into serotonin-depleted brain to restore hippocampal responses to synaptically released serotonin was studied using a serotonin-releasing drug, D-fenfluramine (FFA). In normal rats, FFA enhances reactivity of the dentate gyrus (DG) to perforant-path stimulation, while s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91517-k

    authors: Richter-Levin G,Segal M

    更新日期:1990-06-25 00:00:00

  • Selective alterations in transglutaminase activity of rat superior cervical ganglia in response to neurotransmitters, high potassium and sialic acid-containing compounds.

    abstract::We examined the in vitro effects of neurotransmitters, high KCl as well as sialic acid-containing compounds (GM1; SC) on transglutaminase (TG) activity in isolated superior cervical ganglia (SCG) one week after denervation or axotomy. Following denervation, TG activity in SCG decreased to 83% of the unoperated control...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90352-n

    authors: Ando M,Kunii S,Tatematsu T,Nagata Y

    更新日期:1993-02-26 00:00:00

  • Electroshock afterdischarges are related to neuronal oscillability: neuronal models of Aplysia.

    abstract::Identifiable giant neurons of Aplysia explored intracellularly behave differently at the offset of an intracellular electroshock (IES) or after a synaptic 'tetanization', according to their functional type: neurons of the stable type depolarize and fire at the offset of the IES, anodal or cathodal, thus eliciting an a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90583-2

    authors: Chalazonitis N,Boisson M,Rome-Talbot D,Chagneux R

    更新日期:1982-09-30 00:00:00

  • Myelin basic protein has lectin-like properties.

    abstract::Myelin basic proteins (MBP) obtained from bovine, guinea pig and human nervous tissues exhibited hemagglutinating activity for erythrocytes of several animal species. The activity to each erythrocyte was actually equal among the 3 MBPs. With bovine MBP and chicken erythrocytes, the hemagglutinating activity did not re...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90515-3

    authors: Ikeda K,Yamamoto T

    更新日期:1985-03-11 00:00:00

  • Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity.

    abstract::The present study evaluated whether environmental enrichment-related effects on the development of stereotyped behavior in deer mice were associated with alterations in neuronal metabolic activity. Deer mice were reared under either enriched or standard housing conditions for 60 days following weaning. All mice were t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02472-1

    authors: Turner CA,Yang MC,Lewis MH

    更新日期:2002-05-31 00:00:00

  • Gap-like junctions between neuron cell bodies and glial cells of crayfish.

    abstract::Data reported up to now on neuron-glia relationships, show that neuron cell bodies and glial cells are separated by a narrow intercellular cleft which is considered as the microenvironment of the nervous system, and where neuron-glia exchange occurs. We present here evidence that neuron perikarya and ensheathing glial...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91394-0

    authors: Cuadras J,Martin G,Czternasty G,Bruner J

    更新日期:1985-02-04 00:00:00

  • Protein tyrosine kinase and mitogen-activated protein kinase activation contribute to K(ATP) and K(ca) channel impairment after brain injury.

    abstract::Previous studies have observed that pial artery dilation to activators of the ATP sensitive K (K(ATP)) and calcium sensitive K (K(ca)) channel was blunted following fluid percussion brain injury (FPI) in the piglet. In recent studies in the rat, protein tyrosine kinase (PTK) activation was observed to contribute to K(...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02703-8

    authors: Armstead WM

    更新日期:2002-07-12 00:00:00

  • Adrenergic sympathectomy ablates unmyelinated fibers in the rat 'preganglionic' cervical sympathetic trunk.

    abstract::Classical anatomical depictions of the cervical sympathetic trunk label it as a cholinergic preganglionic structure. We studied the cervical sympathetic trunk of the rat following daily injection for 5 weeks of guanethidine monosulphate, a regimen known to selectively destroy adrenergic neurons outside of the blood-br...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91101-3

    authors: Zochodne DW,Low PA,Dyck PJ

    更新日期:1989-10-02 00:00:00

  • Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area.

    abstract::The central melanocortin system plays a critical role in regulation of energy balance, including thermogenesis in brown adipose tissue (BAT). Activation of the hypothalamic melanocortin signaling stimulates sympathetically-mediated interscapular BAT (IBAT) thermogenesis. The rostral raphe pallidus (rRPa) and adjacent ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.04.006

    authors: Fan W,Morrison SF,Cao WH,Yu P

    更新日期:2007-11-07 00:00:00

  • Dystroglycan is involved in the activation of ERK pathway inducing the change of AQP4 expression in scratch-injured astrocytes.

    abstract::We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.146347

    authors: Zhang G,Ma P,Wan S,Xu J,Yang M,Qiu G,Zhuo F,Xu S,Huo J,Ju Y,Liu H

    更新日期:2019-10-15 00:00:00

  • Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus.

    abstract::The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.01.084

    authors: Campeau S,Nyhuis TJ,Kryskow EM,Masini CV,Babb JA,Sasse SK,Greenwood BN,Fleshner M,Day HE

    更新日期:2010-04-06 00:00:00

  • Habituation of exteroceptive suppression and of exteroceptive reflexes in man as influenced by voluntary contraction.

    abstract::Habituation kinetics were found to vary considerably in different polysynaptic pathways of the brain stem in man. The exteroceptive reflex of the digastric muscle habituates markedly, even for stimuli repeated at 1-min intervals. The second component of the blink reflex habituates for intervals below about 8 sec, but ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90070-6

    authors: Desmedt JE,Godaux E

    更新日期:1976-04-16 00:00:00

  • Dopamine effects on thermosensitive neurons in hypothalamic tissue slices.

    abstract::To understand the role of hypothalamic dopamine in thermoregulation, single unit activity was recorded in vitro, from constantly perfused tissue slices of rat preoptic area and anterior hypothalamus, PO/AH. The firing rate and thermosensitivity of individual PO/AH neurons were determined before, during and after tissu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90364-0

    authors: Scott IM,Boulant JA

    更新日期:1984-07-23 00:00:00

  • Modulatory effects of progesterone upon dopamine release from the corpus striatum of ovariectomized estrogen-treated rats are stereo-specific.

    abstract::We have shown previously that progesterone linked with bovine serum albumin at position 3 of the progesterone molecule (P-3-BSA) was effective in modulating (both stimulating and inhibiting) amphetamine (AMPH)-evoked dopamine (DA) release in vitro from superfused corpus striatal (CS) tissue fragments of ovariectomized...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90395-c

    authors: Dluzen DE,Ramirez VD

    更新日期:1991-01-04 00:00:00

  • Early and permanent effects of monocular deprivation on pattern discrimination and visuomotor behavior in cats.

    abstract::Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90771-x

    authors: Hof-Van Duin JV

    更新日期:1976-07-30 00:00:00

  • A direct projection from the kidney to the brainstem.

    abstract::The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91154-5

    authors: Wyss JM,Donovan MK

    更新日期:1984-04-23 00:00:00

  • Spontaneous activity in rat vestibular nuclei in brain slices and effects of acetylcholine agonists and antagonists.

    abstract::Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02361-2

    authors: Sun Y,Waller HJ,Godfrey DA,Rubin AM

    更新日期:2002-04-26 00:00:00

  • Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical behavioral and catecholaminergic responses.

    abstract::Suction lesions of the right frontal cerebral cortex in rats induce a period of spontaneous hyperactivity. The hyperactivity, as measured by an increase in running wheel activity begins about one week post-operatively and continues throughout the remainder of a 30-day observation period. The increased activity is acco...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91303-2

    authors: Pearlson GD,Robinson RG

    更新日期:1981-08-10 00:00:00

  • Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors.

    abstract::Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor (CRF) biphasically affects performance in tests of learning and memory. In the present study, we used CRF, urocortin (Ucn), a recently cloned CRF homologue, and CRF receptor antagonists, to determine which CRF receptor subtype(s) mediate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03345-0

    authors: Zorrilla EP,Schulteis G,Ormsby A,Klaassen A,Ling N,McCarthy JR,Koob GF,De Souza EB

    更新日期:2002-10-18 00:00:00

  • Noradrenergic innervation of hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in rats.

    abstract::Hypophysiotropic thyrotropin-releasing hormone (TRH)-synthesizing neurons, the central regulators of the hypothalamic-pituitary-thyroid axis, are located in the paraventricular nucleus of the hypothalamus (PVN). These neurons are well-known to be stimulated by cold exposure through activation of ascending brainstem pa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.07.094

    authors: Füzesi T,Wittmann G,Lechan RM,Liposits Z,Fekete C

    更新日期:2009-10-19 00:00:00

  • Electronmicroscopic study of somatostatin-containing neurons in rat arcuate nucleus with special reference to neuronal regulation.

    abstract::After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90312-8

    authors: Ohtsuka M,Hisano S,Daikoku S

    更新日期:1983-03-21 00:00:00

  • Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats.

    abstract::The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02289-1

    authors: Zhang Y,Raap DK,Garcia F,Serres F,Ma Q,Battaglia G,Van de Kar LD

    更新日期:2000-02-07 00:00:00

  • The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.

    abstract::Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.06.027

    authors: Charlton RA,McIntyre DJ,Howe FA,Morris RG,Markus HS

    更新日期:2007-08-20 00:00:00

  • Amyloid precursor protein is localized in growing neurites of neonatal rat brain.

    abstract::Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91329-d

    authors: Masliah E,Mallory M,Ge N,Saitoh T

    更新日期:1992-10-16 00:00:00

  • Cannabinoid receptor activation in CA1 pyramidal cells in adult rat hippocampus.

    abstract::Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02110-7

    authors: Kirby MT,Hampson RE,Deadwyler SA

    更新日期:2000-04-28 00:00:00

  • Inhibition of vasodepressor neurons in the caudal ventrolateral medulla of the rabbit increases both arterial pressure and the release of neuropeptide Y-like immunoreactivity from the spinal cord.

    abstract::The role of bulbospinal neuropeptide Y (NPY)-containing neurons of the rostral ventrolateral medulla in the rabbit in mediating the increase in blood pressure that occurs during inhibition of cells in the caudal ventrolateral medulla was investigated in urethane-anaesthetized rabbits. In the present experiments bilate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91261-3

    authors: Pilowsky PM,Morris MJ,Minson JB,West MJ,Chalmers JP,Willoughby JO,Blessing WW

    更新日期:1987-09-15 00:00:00

  • Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model.

    abstract::Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.09.056

    authors: Ponce-Lopez T,Liy-Salmeron G,Hong E,Meneses A

    更新日期:2011-12-02 00:00:00

  • Effects of different corticosteroids on the brain weight and hippocampal neuronal loss in rats.

    abstract::Equivalent antiinflammatory doses of steroids including betamethasone, methylprednisolone and dexamethasone were administered in the neonatal period in a rat model. In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigate...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.10.051

    authors: Duksal F,Kilic I,Tufan AC,Akdogan I

    更新日期:2009-01-23 00:00:00

  • Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity.

    abstract::The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)01031-2

    authors: Strangman NM,Patrick SL,Hohmann AG,Tsou K,Walker JM

    更新日期:1998-12-07 00:00:00

  • Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus.

    abstract::Aging leads to many changes in the circadian timekeeping system, including reduced sensitivity to phase-resetting signals such as systemic administration of the serotonergic agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). In previous studies, we observed an age-related decrease in 5-HT7 receptor binding s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.02.025

    authors: Duncan MJ,Grear KE,Hoskins MA

    更新日期:2004-05-15 00:00:00