Thrombin promotes pericyte coverage by Tie2 activation in a rat model of intracerebral hemorrhage.

abstract：:7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding ...

journal_title：Brain research

authors： Sircar R,Frusciante MJ,Javitt DC,Zukin SR

更新日期：1989-12-18 00:00:00

abstract：:Elevations in the plasma levels of glucocorticoids are associated with cognitive impairments that have been ascribed to loss of neurons in the hippocampal formation. However, recent studies have strongly challenged this view. In order to clarify this issue, we have employed for the first time the optical fractionator ...

journal_title：Brain research

authors： Sousa N,Madeira MD,Paula-Barbosa MM

更新日期：1998-06-01 00:00:00

abstract：:Evidence is provided that carbonic anhydrase-II is localized in the central nervous system to wide spread systems of oligodendrocytes and restricted astroglia populations, involving both fiber bundles and neuropil. It is suggested that CO2 formed in activated axons may, via carbonic anhydrase-II, give rise to protons ...

journal_title：Brain research

authors： Agnati LF,Tinner B,Staines WA,Väänänen K,Fuxe K

更新日期：1995-04-03 00:00:00

abstract：:The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...

journal_title：Brain research

authors： Abudara V,Jiang RG,Eyzaguirre C

更新日期：2001-10-19 00:00:00

abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...

journal_title：Brain research

authors： González-Mariscal G,García Dalmán C,Jiménez A

更新日期：2015-05-22 00:00:00

abstract：:The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. The RAGE-ligand interaction has a putative role in a range of chronic disorders and is also known to contribute to both inflammatory/degenerative processes as well as regenerati...

journal_title：Brain research

authors： Ma L,Carter RJ,Morton AJ,Nicholson LF

更新日期：2003-03-21 00:00:00

abstract：:We studied whether K+, a potent cerebrovasodilator released by active neurons, participates in the increase in cortical cerebral blood flow (CBF) elicited by stimulation of the cerebellar fastigial nucleus (FN). Rats were anesthetized by continuous administration of halothane (1-3%), paralyzed and artificially ventila...

journal_title：Brain research

authors： Iadecola C,Kraig RP

更新日期：1991-11-01 00:00:00

abstract：:Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...

journal_title：Brain research

authors： Gilbert ME,Mack CM

更新日期：1990-06-11 00:00:00

abstract：:In this study, we investigated the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one, a neurosteroid, on the binding characteristics of [3H]flunitrazepam (2 nM), [3H]muscimol (5 nM), and 4 nM [35S]t-butylbicyclophosphorothionate (TBPS) in cerebral cortex, cerebellum, and hippocampus of control, ethanol-dependent, a...

journal_title：Brain research

authors： Mehta AK,Ticku MK

更新日期：1998-09-14 00:00:00

abstract：:Social defeat is a powerful experience that often leads to drastic physiological and behavioral changes in many animal species. An example of such a change is conditioned defeat in Syrian hamsters. The neurophysiological mechanisms that underlie such changes are not yet fully understood, however, there is evidence tha...

journal_title：Brain research

authors： Jasnow AM,Huhman KL

更新日期：2001-11-30 00:00:00

abstract：:High-resolution positron emission tomography (microPET) allows for repeated observations of brain function in the same animal. In a previous study, using [(18)F] fluorodeoxyglucose (FDG) microPET, we demonstrated diminished glucose metabolism and subsequent recovery in the Neostriatum and thalamus ipsilateral to corti...

journal_title：Brain research

authors： Mir HM,Tatsukawa KJ,Carmichael ST,Chesselet MF,Kornblum HI

更新日期：2004-03-26 00:00:00

abstract：:Light stimulates dopamine (DA) release in the retina. The purpose of this study was to determine the threshold and dose-response relationship between ocular light exposure and retinal DA synthesis in vivo. Groups of dark-adapted rats were exposed to 0, 1, 3, 5, 10, 25, 50, 100 or 1000 microwatts per square centimeter ...

journal_title：Brain research

authors： Brainard GC,Morgan WW

更新日期：1987-10-20 00:00:00

abstract：:Until now, there has been no effective therapy for chronic sensorineural hearing impairment. This study investigated the role of bone marrow cells (BMCs) in cochlear dysfunction. BALB/c mice (2 months of age), a non-presbycusis-prone mouse strain, were lethally irradiated and then transplanted with BMCs from SAMP1 mic...

journal_title：Brain research

authors： Baba S,Iwai H,Inaba M,Kawamoto K,Omae M,Yamashita T,Ikehara S

更新日期：2006-11-20 00:00:00

abstract：:It has been shown that 2-deoxy-D-glucose (2-DG) inhibits glucose utilization and elicits feeding through the lateral hypothalamus. In contrast, 2,5-anhydro-D-mannitol (2,5-AM), blocking glycogenolysis and/or gluconeogenesis, elicits feeding through the ventromedial hypothalamus. The aim of the present study was to det...

journal_title：Brain research

authors： Morita H,Fujimoto K,Sakata T,Kurokawa M,Yoshimatsu H,Noda T,Iwakiri R,Sakai T

更新日期：1996-05-06 00:00:00

abstract：:Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...

journal_title：Brain research

authors： Reznikov LR,Reagan LP,Fadel JR

更新日期：2009-02-23 00:00:00

abstract：:The aim of the present study was to evaluate p38 MAPK activation following focal stroke and determine whether SB 239063, a novel second generation p38 inhibitor, would directly attenuate early neuronal injury. Following permanent middle cerebral artery occlusion (MCAO), brains were dissected into ischemic and non-isch...

journal_title：Brain research

authors： Legos JJ,Erhardt JA,White RF,Lenhard SC,Chandra S,Parsons AA,Tuma RF,Barone FC

更新日期：2001-02-16 00:00:00

abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...

journal_title：Brain research

authors： Nagata T,Tsukamoto Y,Matsuno K,Hayashi Y

更新日期：1989-03-27 00:00:00

abstract：BACKGROUND:Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO2) when administered soon after T...

journal_title：Brain research

authors： Mullah SH,Saha BK,Abutarboush R,Walker PB,Haque A,Arnaud FG,Hazzard B,Auker CR,McCarron RM,Scultetus AH,Moon-Massat P

更新日期：2016-03-01 00:00:00

abstract：:We have previously reported that intracerebroventricular (i.c.v.) injection of either a PKC or PKA inhibitor completely reversed the expression of 5- to 8-fold morphine antinociceptive tolerance. We developed a model of 45-fold morphine tolerance that included a 75-mg morphine pellet and twice daily morphine injection...

journal_title：Brain research

authors： Smith FL,Javed RR,Elzey MJ,Dewey WL

更新日期：2003-09-19 00:00:00

abstract：:There is much debate on the role of the superior colliculus (SC) in turning behaviour. In order to clarify this issue, unilateral kainate lesions were made by infusing 0.25 microgram of kainate at two different anterior planes (0.8 mm apart), in the lateral or in the medial aspects of the deep collicular layers (DLSC)...

journal_title：Brain research

authors： Di Chiara G,Morelli M,Imperato A,Porceddu ML

更新日期：1982-04-08 00:00:00

abstract：:Recent research has shown that familiarity contributes to associative memory when the to-be-associated stimuli are unitized during encoding. However, the specific processes underlying familiarity-based recognition of unitized representations are still indefinite. In this study, we present electrophysiologically dissoc...

journal_title：Brain research

authors： Wiegand I,Bader R,Mecklinger A

更新日期：2010-11-11 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

journal_title：Brain research

authors： Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

更新日期：2009-01-19 00:00:00

abstract：:Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...

journal_title：Brain research

authors： Zhang X,Deng M,Ran G,Tang Q,Xu W,Ma Y,Chen X

更新日期：2018-11-15 00:00:00

abstract：:The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...

journal_title：Brain research

authors： Lidov HG,Molliver ME

更新日期：1982-01-01 00:00:00

abstract：:A combined retrograde transport and immunocytochemical study was carried out to determine the projections of the large glycine-immunoreactive neurons in the ventral cochlear nucleus of the guinea pig. Horseradish peroxidase (HRP) was injected into the contralateral cochlear nucleus, and cochlear nucleus sections were ...

journal_title：Brain research

authors： Wenthold RJ

更新日期：1987-07-07 00:00:00

abstract：:Fast axonal transport and neuronal protein synthesis was studied in the isolated nervous system of Aplysia californica. The abdominal ganglion with attached pleural-abdominal connectives (PAC) was removed and the ganglion pulse-labelled with [35S]methionine for 30 min in vitro. The axon containing connectives were lig...

journal_title：Brain research

authors： Drake PF,Oblinger MM,Lasek RJ

更新日期：1985-04-15 00:00:00

abstract：:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...

journal_title：Brain research

authors： Wright KP Jr,Badia P,Myers BL,Plenzler SC,Hakel M

更新日期：1997-01-30 00:00:00

abstract：:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy fr...

journal_title：Brain research

authors： Whitehouse PJ,Martino AM,Antuono PG,Lowenstein PR,Coyle JT,Price DL,Kellar KJ

更新日期：1986-04-16 00:00:00

abstract：:To better understand the contributions of effort on cortical activation associated with motor tasks, healthy participants with varying capacities for isolating the control of individual finger movements performed tasks consisting of a single concurrent abduction of all digits (Easy) and paired finger abduction with di...

journal_title：Brain research

authors： Mochizuki G,Hoque T,Mraz R,Macintosh BJ,Graham SJ,Black SE,Staines WR,McIlroy WE

更新日期：2009-12-08 00:00:00

abstract：:Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the therapeutic time window of honokiol microemulsion on cerebral ischemia-reperfusion injury to support its potential for fut...

journal_title：Brain research

authors： Hu Z,Bian X,Liu X,Zhu Y,Zhang X,Chen S,Wang K,Wang Y

更新日期：2013-01-23 00:00:00